Gene: ENSG00000154229 (Homo sapiens)

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Gene Identifier
ENSG00000154229
Transcript Identifier
ENST00000413366
Gene Type
Coding gene
Location
17 : 66302852-66804037 : positive

Family Information

Homologous gene family
HOM03P000015
(1237 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P005549
(15 genes in 6 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
protein kinase C, alpha

Identifiers

Type Value
pidENSP00000408695
HGNC9393
UniprotP17252
UniprotL7RSM7

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000188
IEA
Genome Projectinactivation of MAPK activity
GO:0001933
IEA
Genome Projectnegative regulation of protein phosphorylation
GO:0001934
IEA
Genome Projectpositive regulation of protein phosphorylation
GO:0002026
IEA
Genome Projectregulation of the force of heart contraction
GO:0002062
IEA
Genome Projectchondrocyte differentiation
GO:0006468
IDA
IEA
Genome Projectprotein phosphorylation
GO:0006469
IEA
Genome Projectnegative regulation of protein kinase activity
GO:0006874
IEA
Genome Projectcellular calcium ion homeostasis
GO:0006937
IEA
Genome Projectregulation of muscle contraction
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0030593
IEA
Genome Projectneutrophil chemotaxis
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0036289
IEA
Genome Projectpeptidyl-serine autophosphorylation
GO:0046325
IEA
Genome Projectnegative regulation of glucose import
GO:0046627
IEA
Genome Projectnegative regulation of insulin receptor signaling pathway
GO:0050729
IEA
Genome Projectpositive regulation of inflammatory response
GO:0050730
IEA
Genome Projectregulation of peptidyl-tyrosine phosphorylation
GO:0050930
IEA
Genome Projectinduction of positive chemotaxis
GO:0071322
IEA
Genome Projectcellular response to carbohydrate stimulus
GO:0097193
IEA
Genome Projectintrinsic apoptotic signaling pathway
GO:0000278
TAS
Genome Projectmitotic cell cycle
GO:0001525
IEA
Genome Projectangiogenesis
GO:0001938
IMP
Genome Projectpositive regulation of endothelial cell proliferation
GO:0002159
IMP
Genome Projectdesmosome assembly
GO:0006112
TAS
Genome Projectenergy reserve metabolic process
GO:0006915
IEA
Genome Projectapoptotic process
GO:0007077
TAS
Genome Projectmitotic nuclear envelope disassembly
GO:0007155
IEA
Genome Projectcell adhesion
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007190
ISS
Genome Projectactivation of adenylate cyclase activity
GO:0007194
ISS
Genome Projectnegative regulation of adenylate cyclase activity
GO:0007202
TAS
Genome Projectactivation of phospholipase C activity
GO:0007268
TAS
Genome Projectsynaptic transmission
GO:0007596
TAS
Genome Projectblood coagulation
GO:0007603
TAS
Genome Projectphototransduction, visible light
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0010467
TAS
Genome Projectgene expression
GO:0010595
IMP
Genome Projectpositive regulation of endothelial cell migration
GO:0010613
ISS
Genome Projectpositive regulation of cardiac muscle hypertrophy
GO:0016056
TAS
Genome Projectrhodopsin mediated signaling pathway
GO:0022400
TAS
Genome Projectregulation of rhodopsin mediated signaling pathway
GO:0030168
TAS
Genome Projectplatelet activation
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0030335
IMP
Genome Projectpositive regulation of cell migration
GO:0031666
IMP
Genome Projectpositive regulation of lipopolysaccharide-mediated signaling pathway
GO:0034351
IMP
Genome Projectnegative regulation of glial cell apoptotic process
GO:0035408
IDA
Genome Projecthistone H3-T6 phosphorylation
GO:0043536
IDA
Genome Projectpositive regulation of blood vessel endothelial cell migration
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045651
ISS
Genome Projectpositive regulation of macrophage differentiation
GO:0045766
IMP
Genome Projectpositive regulation of angiogenesis
GO:0045785
IMP
Genome Projectpositive regulation of cell adhesion
GO:0045931
IMP
Genome Projectpositive regulation of mitotic cell cycle
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0050796
TAS
Genome Projectregulation of insulin secretion
GO:0070374
ISS
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0070555
IMP
Genome Projectresponse to interleukin-1
GO:0090330
IDA
Genome Projectregulation of platelet aggregation
GO:0097190
TAS
Genome Projectapoptotic signaling pathway
GO:2000707
ISS
Genome Projectpositive regulation of dense core granule biogenesis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IDA
IEA
Genome Projectprotein kinase activity
GO:0004674
EXP
TAS, IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004697
ISS
TAS, IEA
Genome Projectprotein kinase C activity
GO:0004698
IEA
Genome Projectcalcium-dependent protein kinase C activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0019899
IDA
Genome Projectenzyme binding
GO:0035403
IDA
Genome Projecthistone kinase activity (H3-T6 specific)

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001750
IEA
Genome Projectphotoreceptor outer segment
GO:0005634
IEA
Genome Projectnucleus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0030425
IEA
Genome Projectdendrite
GO:0043025
IEA
Genome Projectneuronal cell body
GO:0045177
IEA
Genome Projectapical part of cell
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005739
IDA
IEA
Genome Projectmitochondrion
GO:0005783
IDA
Genome Projectendoplasmic reticulum
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0031966
IEA
Genome Projectmitochondrial membrane
GO:0048471
ISS
Genome Projectperinuclear region of cytoplasm
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000008C2 domain
IPR000719Protein kinase domain
IPR000961AGC-kinase, C-terminal
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR014375Protein kinase C, alpha/beta/gamma types
IPR017441Protein kinase, ATP binding site
IPR020454Diacylglycerol/phorbol-ester binding

No MapMan annotations defined for this gene.