Gene: ENSG00000154188 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000154188
Transcript Identifier
ENST00000517746
Gene Type
Coding gene
Location
8 : 107251855-107497558 : negative

Family Information

Homologous gene family
HOM03P000911
(65 genes in 6 species)
specific family
Orthologous gene family
ORTHO03P034344
(3 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
angiopoietin 1

Identifiers

Type Value
pidENSP00000428340
HGNC484
UniprotQ15389

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001525
IEA
Genome Projectangiogenesis
GO:0001701
IEA
Genome Projectin utero embryonic development
GO:0001933
IEA
Genome Projectnegative regulation of protein phosphorylation
GO:0002040
IDA
Genome Projectsprouting angiogenesis
GO:0002092
IDA
Genome Projectpositive regulation of receptor internalization
GO:0002740
IEA
Genome Projectnegative regulation of cytokine secretion involved in immune response
GO:0007162
IDA
Genome Projectnegative regulation of cell adhesion
GO:0007169
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007171
IDA
Genome Projectactivation of transmembrane receptor protein tyrosine kinase activity
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007596
TAS
Genome Projectblood coagulation
GO:0010595
IDA
Genome Projectpositive regulation of endothelial cell migration
GO:0014068
IEA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0014842
IDA
Genome Projectregulation of skeletal muscle satellite cell proliferation
GO:0030097
IEA
Genome Projecthemopoiesis
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030210
IDA
Genome Projectheparin biosynthetic process
GO:0031398
IDA
Genome Projectpositive regulation of protein ubiquitination
GO:0031589
IEA
Genome Projectcell-substrate adhesion
GO:0032680
IEA
Genome Projectregulation of tumor necrosis factor production
GO:0033138
IEA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0034394
IDA
Genome Projectprotein localization to cell surface
GO:0042308
IEA
Genome Projectnegative regulation of protein import into nucleus
GO:0043066
IDA
Genome Projectnegative regulation of apoptotic process
GO:0043116
IDA
Genome Projectnegative regulation of vascular permeability
GO:0043122
IEA
Genome Projectregulation of I-kappaB kinase/NF-kappaB signaling
GO:0043393
IEA
Genome Projectregulation of protein binding
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0043536
IDA
Genome Projectpositive regulation of blood vessel endothelial cell migration
GO:0045785
IEA
Genome Projectpositive regulation of cell adhesion
GO:0048014
IDA
IEA
Genome ProjectTie signaling pathway
GO:0050731
IDA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050900
TAS
Genome Projectleukocyte migration
GO:0050918
IDA
Genome Projectpositive chemotaxis
GO:0051897
IDA
Genome Projectpositive regulation of protein kinase B signaling
GO:0070374
IDA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0072012
ISS
IEA
Genome Projectglomerulus vasculature development
GO:2000352
IDA
Genome Projectnegative regulation of endothelial cell apoptotic process
GO:2000446
IEA
Genome Projectregulation of macrophage migration inhibitory factor signaling pathway
GO:0001936
IDA
Genome Projectregulation of endothelial cell proliferation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005102
IEA
Genome Projectreceptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0030971
IPI
IEA
Genome Projectreceptor tyrosine kinase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005615
IDA
Genome Projectextracellular space
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005902
IDA
Genome Projectmicrovillus
GO:0045121
IDA
Genome Projectmembrane raft
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002181Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR014715Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
IPR014716Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
IPR020837Fibrinogen, conserved site
IPR028843Angiopoietin-1

No MapMan annotations defined for this gene.