Gene: ENSG00000153162 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000153162
Transcript Identifier
ENST00000283147
Gene Type
Coding gene
Location
6 : 7726956-7880343 : positive

Family Information

Homologous gene family
HOM03P001000
(62 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P010583
(8 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
bone morphogenetic protein 6

Identifiers

Type Value
pidENSP00000283147
HGNC1073
UniprotP22004

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
ISS
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001501
TAS
Genome Projectskeletal system development
GO:0001503
IEA
Genome Projectossification
GO:0001649
IEA
Genome Projectosteoblast differentiation
GO:0001654
IEA
Genome Projecteye development
GO:0001822
IEA
Genome Projectkidney development
GO:0001938
IEA
Genome Projectpositive regulation of endothelial cell proliferation
GO:0001958
IEA
Genome Projectendochondral ossification
GO:0003323
IDA
Genome Projecttype B pancreatic cell development
GO:0006879
ISS
IEA
Genome Projectcellular iron ion homeostasis
GO:0006954
IEA
Genome Projectinflammatory response
GO:0006955
IMP
Genome Projectimmune response
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0010039
IEA
Genome Projectresponse to iron ion
GO:0010862
IDA
ISS
Genome Projectpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014823
IEA
Genome Projectresponse to activity
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030501
IDA
Genome Projectpositive regulation of bone mineralization
GO:0030509
IDA, IMP
ISS
Genome ProjectBMP signaling pathway
GO:0030539
IEA
Genome Projectmale genitalia development
GO:0031666
ISS
Genome Projectpositive regulation of lipopolysaccharide-mediated signaling pathway
GO:0032026
IEA
Genome Projectresponse to magnesium ion
GO:0032332
IEA
Genome Projectpositive regulation of chondrocyte differentiation
GO:0032349
IDA
Genome Projectpositive regulation of aldosterone biosynthetic process
GO:0032526
IEA
Genome Projectresponse to retinoic acid
GO:0040007
IEA
Genome Projectgrowth
GO:0042981
IBA
Genome Projectregulation of apoptotic process
GO:0043408
IBA
Genome Projectregulation of MAPK cascade
GO:0045603
IEA
Genome Projectpositive regulation of endothelial cell differentiation
GO:0045666
IEA
Genome Projectpositive regulation of neuron differentiation
GO:0045669
IDA
IEA
Genome Projectpositive regulation of osteoblast differentiation
GO:0045944
IDA, IGI
ISS
NAS
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0050679
IDA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050714
NAS
Genome Projectpositive regulation of protein secretion
GO:0051216
IEA
Genome Projectcartilage development
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0060391
ISS
Genome Projectpositive regulation of SMAD protein import into nucleus
GO:0060395
IDA
ISS
Genome ProjectSMAD protein signal transduction
GO:0060586
ISS
Genome Projectmulticellular organismal iron ion homeostasis
GO:0071260
IEA
Genome Projectcellular response to mechanical stimulus
GO:0071281
ISS
Genome Projectcellular response to iron ion
GO:0071773
IMP
Genome Projectcellular response to BMP stimulus
GO:2000105
NAS
Genome Projectpositive regulation of DNA-dependent DNA replication
GO:2000860
IEA
Genome Projectpositive regulation of aldosterone secretion

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005125
IBA
IEA
Genome Projectcytokine activity
GO:0005160
IBA
Genome Projecttransforming growth factor beta receptor binding
GO:0008083
IEA
Genome Projectgrowth factor activity
GO:0046982
IDA
Genome Projectprotein heterodimerization activity
GO:0070700
IDA
Genome ProjectBMP receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
IBA
IEA
Genome Projectextracellular space
GO:0005737
IEA
Genome Projectcytoplasm
GO:0031988
IEA
Genome Projectmembrane-bounded vesicle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001111Transforming growth factor-beta, N-terminal
IPR001839Transforming growth factor-beta, C-terminal
IPR015615Transforming growth factor-beta-related
IPR017948Transforming growth factor beta, conserved site
IPR029034Cystine-knot cytokine

No MapMan annotations defined for this gene.