Gene: ENSG00000151694 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000151694
Transcript Identifier
ENST00000310823
Gene Type
Coding gene
Location
2 : 9490177-9555605 : negative

Family Information

Homologous gene family
HOM03P008887
(9 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P028789
(4 genes in 4 species)
specific family

Descriptions

gene_descr
ADAM metallopeptidase domain 17

Identifiers

Type Value
pidENSP00000309968
HGNC195
UniprotP78536
UniprotB2RNB2

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006508
IDA
IEA
Genome Projectproteolysis
GO:0001666
IDA
Genome Projectresponse to hypoxia
GO:0001934
IMP
Genome Projectpositive regulation of protein phosphorylation
GO:0002446
IC
Genome Projectneutrophil mediated immunity
GO:0002467
ISS
Genome Projectgerminal center formation
GO:0002690
IC
Genome Projectpositive regulation of leukocyte chemotaxis
GO:0006509
IDA, IMP
Genome Projectmembrane protein ectodomain proteolysis
GO:0007155
IDA
Genome Projectcell adhesion
GO:0007166
TAS
Genome Projectcell surface receptor signaling pathway
GO:0007173
IDA
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007219
IEA
Genome ProjectNotch signaling pathway
GO:0007220
IDA
Genome ProjectNotch receptor processing
GO:0008284
IMP
Genome Projectpositive regulation of cell proliferation
GO:0010820
IMP
Genome Projectpositive regulation of T cell chemotaxis
GO:0022617
TAS
Genome Projectextracellular matrix disassembly
GO:0030183
ISS
Genome ProjectB cell differentiation
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0030307
IMP
Genome Projectpositive regulation of cell growth
GO:0030335
IMP
Genome Projectpositive regulation of cell migration
GO:0030511
ISS
Genome Projectpositive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512
IMP
Genome Projectnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0030574
TAS
Genome Projectcollagen catabolic process
GO:0031293
TAS
Genome Projectmembrane protein intracellular domain proteolysis
GO:0031659
IDA
Genome Projectpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0032496
IDA
Genome Projectresponse to lipopolysaccharide
GO:0032722
IMP
Genome Projectpositive regulation of chemokine production
GO:0033025
ISS
Genome Projectregulation of mast cell apoptotic process
GO:0033077
ISS
Genome ProjectT cell differentiation in thymus
GO:0033209
TAS
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0033627
IDA
Genome Projectcell adhesion mediated by integrin
GO:0035313
IEP
Genome Projectwound healing, spreading of epidermal cells
GO:0035625
IMP
Genome Projectepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0042493
ISS
Genome Projectresponse to drug
GO:0045741
IDA, IMP
Genome Projectpositive regulation of epidermal growth factor-activated receptor activity
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048536
ISS
Genome Projectspleen development
GO:0048870
ISS
Genome Projectcell motility
GO:0050830
IMP
Genome Projectdefense response to Gram-positive bacterium
GO:0051088
IDA, IMP
Genome ProjectPMA-inducible membrane protein ectodomain proteolysis
GO:0051272
ISS
Genome Projectpositive regulation of cellular component movement
GO:0055099
IDA
Genome Projectresponse to high density lipoprotein particle
GO:0060397
TAS
Genome ProjectJAK-STAT cascade involved in growth hormone signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004222
IDA, IMP
TAS, IEA
Genome Projectmetalloendopeptidase activity
GO:0008237
IDA, IMP
TAS, IEA
Genome Projectmetallopeptidase activity
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0005112
IDA
Genome ProjectNotch binding
GO:0005138
IPI
Genome Projectinterleukin-6 receptor binding
GO:0005178
IPI
Genome Projectintegrin binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008233
IEA
Genome Projectpeptidase activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0017124
IEA
Genome ProjectSH3 domain binding
GO:0030165
IPI
Genome ProjectPDZ domain binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005886
TAS
Genome Projectplasma membrane
GO:0005887
IDA
Genome Projectintegral component of plasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0015629
IDA
Genome Projectactin cytoskeleton
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016324
IDA
Genome Projectapical plasma membrane
GO:0045121
IDA
Genome Projectmembrane raft
GO:0005911
IDA
Genome Projectcell-cell junction
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0032587
IDA
Genome Projectruffle membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001590Peptidase M12B, ADAM/reprolysin
IPR001762Disintegrin domain
IPR002870Peptidase M12B, propeptide
IPR024079Metallopeptidase, catalytic domain
IPR032029ADAM17, membrane-proximal domain

No MapMan annotations defined for this gene.