Gene: ENSG00000151577 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000151577
Transcript Identifier
ENST00000383673
Gene Type
Coding gene
Location
3 : 114128716-114171992 : negative

Family Information

Homologous gene family
HOM03P000241
(150 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P074388
(2 genes in 2 species)
specific family

Descriptions

gene_descr
dopamine receptor D3

Identifiers

Type Value
pidENSP00000373169
HGNC3024
UniprotP35462
UniprotX5D2G4

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001963
IEA
Genome Projectsynaptic transmission, dopaminergic
GO:0001975
IEA
Genome Projectresponse to amphetamine
GO:0002016
IEA
Genome Projectregulation of blood volume by renin-angiotensin
GO:0002031
IDA
IEA
Genome ProjectG-protein coupled receptor internalization
GO:0006874
IDA
Genome Projectcellular calcium ion homeostasis
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007186
IDA
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007191
IDA
Genome Projectadenylate cyclase-activating dopamine receptor signaling pathway
GO:0007194
IDA
IEA
Genome Projectnegative regulation of adenylate cyclase activity
GO:0007195
IDA
IEA
Genome Projectadenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212
IEA
Genome Projectdopamine receptor signaling pathway
GO:0007268
IBA
Genome Projectsynaptic transmission
GO:0007606
IBA
Genome Projectsensory perception of chemical stimulus
GO:0007611
NAS
Genome Projectlearning or memory
GO:0007612
NAS
Genome Projectlearning
GO:0007626
ISS
IEA
Genome Projectlocomotory behavior
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008542
ISS
IEA
Genome Projectvisual learning
GO:0014059
ISS
IEA
Genome Projectregulation of dopamine secretion
GO:0019216
IEA
Genome Projectregulation of lipid metabolic process
GO:0030814
IDA
IEA
Genome Projectregulation of cAMP metabolic process
GO:0032416
IEA
Genome Projectnegative regulation of sodium:proton antiporter activity
GO:0032467
IMP
Genome Projectpositive regulation of cytokinesis
GO:0032922
ISS
IEA
Genome Projectcircadian regulation of gene expression
GO:0034776
IDA
Genome Projectresponse to histamine
GO:0035176
NAS
Genome Projectsocial behavior
GO:0035483
IEA
Genome Projectgastric emptying
GO:0035815
IEA
Genome Projectpositive regulation of renal sodium excretion
GO:0040012
IEA
Genome Projectregulation of locomotion
GO:0040014
IEA
Genome Projectregulation of multicellular organism growth
GO:0042220
IEP
IEA
Genome Projectresponse to cocaine
GO:0042417
IC
Genome Projectdopamine metabolic process
GO:0042493
ISS
IEA
Genome Projectresponse to drug
GO:0043278
ISS
IEA
Genome Projectresponse to morphine
GO:0045187
IEA
Genome Projectregulation of circadian sleep/wake cycle, sleep
GO:0045776
ISS
IEA
Genome Projectnegative regulation of blood pressure
GO:0045840
ISS
IEA
Genome Projectpositive regulation of mitotic nuclear division
GO:0045944
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046717
ISS
IEA
Genome Projectacid secretion
GO:0048148
IEP
ISS
IEA
Genome Projectbehavioral response to cocaine
GO:0048715
ISS
IEA
Genome Projectnegative regulation of oligodendrocyte differentiation
GO:0050482
IDA
Genome Projectarachidonic acid secretion
GO:0050709
IDA
Genome Projectnegative regulation of protein secretion
GO:0050883
ISS
IEA
Genome Projectmusculoskeletal movement, spinal reflex action
GO:0051584
IC
Genome Projectregulation of dopamine uptake involved in synaptic transmission
GO:0051898
ISS
IEA
Genome Projectnegative regulation of protein kinase B signaling
GO:0060134
IMP
Genome Projectprepulse inhibition
GO:0060160
IEA
Genome Projectnegative regulation of dopamine receptor signaling pathway
GO:0060161
ISS
IEA
Genome Projectpositive regulation of dopamine receptor signaling pathway
GO:0090325
IEA
Genome Projectregulation of locomotion involved in locomotory behavior
GO:0010579
IBA
Genome Projectpositive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0045471
ISS
IEA
Genome Projectresponse to ethanol

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001591
IDA
ISS
IEA
Genome Projectdopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0004930
IEA
Genome ProjectG-protein coupled receptor activity
GO:0004952
IEA
Genome Projectdopamine neurotransmitter receptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008144
IDA
ISS
IEA
Genome Projectdrug binding
GO:0008227
IBA
Genome ProjectG-protein coupled amine receptor activity
GO:0019904
IEA
Genome Projectprotein domain specific binding
GO:0031748
IEA
Genome ProjectD1 dopamine receptor binding
GO:0035240
IEA
Genome Projectdopamine binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005887
IDA
IC, IEA
Genome Projectintegral component of plasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030139
IEA
Genome Projectendocytic vesicle
GO:0042995
IEA
Genome Projectcell projection
GO:0045177
IEA
Genome Projectapical part of cell

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000276G protein-coupled receptor, rhodopsin-like
IPR000929Dopamine receptor family
IPR001620Dopamine D3 receptor
IPR017452GPCR, rhodopsin-like, 7TM

No MapMan annotations defined for this gene.