Gene: ENSG00000151422 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000151422
Transcript Identifier
ENST00000281092
Gene Type
Coding gene
Location
5 : 108798183-109187575 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P018281
(5 genes in 4 species)
specific family

Descriptions

gene_descr
fer (fps/fes related) tyrosine kinase

Identifiers

Type Value
pidENSP00000281092
HGNC3655
UniprotP16591
UniprotW0S0X4

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000226
IMP
Genome Projectmicrotubule cytoskeleton organization
GO:0000278
IMP
Genome Projectmitotic cell cycle
GO:0001932
ISS
IEA
Genome Projectregulation of protein phosphorylation
GO:0006468
TAS, IEA
Genome Projectprotein phosphorylation
GO:0006935
IBA
IEA
Genome Projectchemotaxis
GO:0007155
IBA
IEA
Genome Projectcell adhesion
GO:0007165
IEA
Genome Projectsignal transduction
GO:0008283
IMP
IEA
Genome Projectcell proliferation
GO:0008284
IMP
TAS
Genome Projectpositive regulation of cell proliferation
GO:0010591
IDA
Genome Projectregulation of lamellipodium assembly
GO:0010762
IEA
Genome Projectregulation of fibroblast migration
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016477
IBA
Genome Projectcell migration
GO:0018108
IDA
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0019221
IMP
Genome Projectcytokine-mediated signaling pathway
GO:0030154
IBA
Genome Projectcell differentiation
GO:0030335
IMP
IEA
Genome Projectpositive regulation of cell migration
GO:0030838
IMP
Genome Projectpositive regulation of actin filament polymerization
GO:0031532
ISS
IEA
Genome Projectactin cytoskeleton reorganization
GO:0032496
ISS
IEA
Genome Projectresponse to lipopolysaccharide
GO:0032869
ISS
IEA
Genome Projectcellular response to insulin stimulus
GO:0033007
ISS
IEA
Genome Projectnegative regulation of mast cell activation involved in immune response
GO:0034446
ISS
IEA
Genome Projectsubstrate adhesion-dependent cell spreading
GO:0034614
ISS
IEA
Genome Projectcellular response to reactive oxygen species
GO:0035426
ISS
IEA
Genome Projectextracellular matrix-cell signaling
GO:0035556
TAS
Genome Projectintracellular signal transduction
GO:0036006
IMP
Genome Projectcellular response to macrophage colony-stimulating factor stimulus
GO:0036119
ISS
IEA
Genome Projectresponse to platelet-derived growth factor
GO:0038028
ISS
IEA
Genome Projectinsulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038083
IBA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0038095
ISS, IBA
IEA
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038109
ISS
IEA
Genome ProjectKit signaling pathway
GO:0042058
IMP
IEA
Genome Projectregulation of epidermal growth factor receptor signaling pathway
GO:0042503
IDA
Genome Projecttyrosine phosphorylation of Stat3 protein
GO:0043304
IBA
Genome Projectregulation of mast cell degranulation
GO:0044331
ISS
IEA
Genome Projectcell-cell adhesion mediated by cadherin
GO:0045087
IBA
Genome Projectinnate immune response
GO:0046777
IDA
Genome Projectprotein autophosphorylation
GO:0048008
ISS
TAS, IEA
Genome Projectplatelet-derived growth factor receptor signaling pathway
GO:0050904
ISS
IEA
Genome Projectdiapedesis
GO:0051092
IMP
IEA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0070102
IMP
Genome Projectinterleukin-6-mediated signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0003779
IEA
Genome Projectactin binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
TAS, IEA
Genome Projectprotein tyrosine kinase activity
GO:0004715
IDA
IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0005154
IDA
IEA
Genome Projectepidermal growth factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008092
IEA
Genome Projectcytoskeletal protein binding
GO:0008157
IEA
Genome Projectprotein phosphatase 1 binding
GO:0008289
IDA
IEA
Genome Projectlipid binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0017137
IEA
Genome ProjectRab GTPase binding
GO:0019901
IEA
Genome Projectprotein kinase binding
GO:0045295
IEA
Genome Projectgamma-catenin binding
GO:0045296
IEA
Genome Projectcadherin binding
GO:0050839
IEA
Genome Projectcell adhesion molecule binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005886
IEA
Genome Projectplasma membrane
GO:0005938
IEA
Genome Projectcell cortex
GO:0016020
IEA
Genome Projectmembrane
GO:0030054
IDA
IEA
Genome Projectcell junction
GO:0031234
IDA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0042995
IEA
Genome Projectcell projection
GO:0000790
IDA
Genome Projectnuclear chromatin
GO:0015629
IDA
Genome Projectactin cytoskeleton
GO:0015630
IDA
Genome Projectmicrotubule cytoskeleton
GO:0030027
IDA
Genome Projectlamellipodium

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR000980SH2 domain
IPR001060FCH domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR016250Tyrosine-protein kinase, Fes/Fps type
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain
IPR028539Tyrosine-protein kinase Fer
IPR031160F-BAR domain

No MapMan annotations defined for this gene.