Gene: ENSG00000150457 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000150457
Transcript Identifier
ENST00000382592
Gene Type
Coding gene
Location
13 : 20974870-21046026 : negative

Family Information

Homologous gene family
HOM03P000015
(1237 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P034424
(3 genes in 2 species)
specific family

Descriptions

gene_descr
large tumor suppressor kinase 2

Identifiers

Type Value
pidENSP00000372035
HGNC6515
UniprotQ9NRM7
UniprotA0A024RDM3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006468
IDA
IEA
Genome Projectprotein phosphorylation
GO:0007067
IEA
Genome Projectmitotic nuclear division
GO:0016310
IEA
Genome Projectphosphorylation
GO:0030216
IEA
Genome Projectkeratinocyte differentiation
GO:0034613
IEA
Genome Projectcellular protein localization
GO:0035329
IDA
TAS, IEA
Genome Projecthippo signaling
GO:0046620
IBA
IEA
Genome Projectregulation of organ growth
GO:0000082
IDA
Genome ProjectG1/S transition of mitotic cell cycle
GO:0007049
IEA
Genome Projectcell cycle
GO:0009755
IDA
Genome Projecthormone-mediated signaling pathway
GO:0018105
IBA
Genome Projectpeptidyl-serine phosphorylation
GO:0035556
IDA
Genome Projectintracellular signal transduction
GO:0043065
IBA
Genome Projectpositive regulation of apoptotic process
GO:0045736
IDA
Genome Projectnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051301
IEA
Genome Projectcell division
GO:0090090
IMP
Genome Projectnegative regulation of canonical Wnt signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
IDA
TAS, IEA
Genome Projectprotein serine/threonine kinase activity
GO:0005524
IDA
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
IEA
Genome Projectintracellular
GO:0000922
IDA
IEA
Genome Projectspindle pole
GO:0005634
IDA
NAS, IEA
Genome Projectnucleus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005815
IDA
IEA
Genome Projectmicrotubule organizing center
GO:0005829
TAS
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR000961AGC-kinase, C-terminal
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR009060UBA-like
IPR011009Protein kinase-like domain
IPR015940Ubiquitin-associated domain
IPR017441Protein kinase, ATP binding site
IPR028742Serine/threonine-protein kinase LATS2

No MapMan annotations defined for this gene.