Gene: ENSG00000149311 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000149311
Transcript Identifier
ENST00000452508
Gene Type
Coding gene
Location
11 : 108227625-108365508 : positive

Family Information

Homologous gene family
HOM03P000164
(189 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P001813
(35 genes in 31 species)
specific family

Descriptions

gene_descr
ATM serine/threonine kinase

Identifiers

Type Value
pidENSP00000388058
HGNC795
UniprotQ13315
UniprotA0A024R3C7

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000077
IEA
Genome ProjectDNA damage checkpoint
GO:0000723
IEA
Genome Projecttelomere maintenance
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0001756
IEA
Genome Projectsomitogenesis
GO:0002331
ISS
IEA
Genome Projectpre-B cell allelic exclusion
GO:0006281
TAS, IEA
Genome ProjectDNA repair
GO:0006915
IEA
Genome Projectapoptotic process
GO:0006974
IMP
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0007292
IEA
Genome Projectfemale gamete generation
GO:0007420
IEA
Genome Projectbrain development
GO:0007507
IEA
Genome Projectheart development
GO:0008340
IEA
Genome Projectdetermination of adult lifespan
GO:0008630
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0010212
IDA
IEA
Genome Projectresponse to ionizing radiation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016572
IEA
Genome Projecthistone phosphorylation
GO:0033151
IEA
Genome ProjectV(D)J recombination
GO:0035404
IEA
Genome Projecthistone-serine phosphorylation
GO:0042159
IEA
Genome Projectlipoprotein catabolic process
GO:0043525
IEA
Genome Projectpositive regulation of neuron apoptotic process
GO:0046777
IDA
IEA
Genome Projectprotein autophosphorylation
GO:0048599
IEA
Genome Projectoocyte development
GO:0051402
IEA
Genome Projectneuron apoptotic process
GO:0051726
IEA
Genome Projectregulation of cell cycle
GO:0090399
IMP
IEA
Genome Projectreplicative senescence
GO:0000724
IBA
TAS
Genome Projectdouble-strand break repair via homologous recombination
GO:0006302
TAS
Genome Projectdouble-strand break repair
GO:0006468
IDA
Genome Projectprotein phosphorylation
GO:0006975
IDA
Genome ProjectDNA damage induced protein phosphorylation
GO:0006977
TAS
Genome ProjectDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007049
IEA
Genome Projectcell cycle
GO:0007050
IMP
Genome Projectcell cycle arrest
GO:0007094
IMP
Genome Projectmitotic spindle assembly checkpoint
GO:0007131
TAS
Genome Projectreciprocal meiotic recombination
GO:0007165
TAS
Genome Projectsignal transduction
GO:0018105
IDA
Genome Projectpeptidyl-serine phosphorylation
GO:0030889
IMP
Genome Projectnegative regulation of B cell proliferation
GO:0034605
TAS
Genome Projectcellular response to heat
GO:0036092
IMP
Genome Projectphosphatidylinositol-3-phosphate biosynthetic process
GO:0043065
IMP
Genome Projectpositive regulation of apoptotic process
GO:0043517
IMP
Genome Projectpositive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0071044
IDA
Genome Projecthistone mRNA catabolic process
GO:0071480
IDA
Genome Projectcellular response to gamma radiation
GO:0072434
IMP
Genome Projectsignal transduction involved in mitotic G2 DNA damage checkpoint
GO:1900034
TAS
Genome Projectregulation of cellular response to heat

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
IDA
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0016773
IEA
Genome Projectphosphotransferase activity, alcohol group as acceptor
GO:0035174
IEA
Genome Projecthistone serine kinase activity
GO:0003677
IEA
Genome ProjectDNA binding
GO:0004677
IDA
Genome ProjectDNA-dependent protein kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0016303
IMP
Genome Project1-phosphatidylinositol-3-kinase activity
GO:0032403
IDA
Genome Projectprotein complex binding
GO:0046983
IDA
Genome Projectprotein dimerization activity
GO:0047485
IDA
Genome Projectprotein N-terminus binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
Genome Projectnucleus
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005819
IEA
Genome Projectspindle
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0016023
IEA
Genome Projectcytoplasmic membrane-bounded vesicle
GO:0031410
IEA
Genome Projectcytoplasmic vesicle
GO:0000781
IDA
Genome Projectchromosome, telomeric region

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000403Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR003151PIK-related kinase, FAT
IPR003152FATC domain
IPR011009Protein kinase-like domain
IPR014009PIK-related kinase
IPR015519Serine/threonine-protein kinase ATM
IPR016024Armadillo-type fold
IPR018936Phosphatidylinositol 3/4-kinase, conserved site
IPR021668Telomere-length maintenance and DNA damage repair

No MapMan annotations defined for this gene.