Gene: ENSG00000149295 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000149295
Transcript Identifier
ENST00000538967
Gene Type
Coding gene
Location
11 : 113410727-113424651 : negative

Family Information

Homologous gene family
HOM03P000241
(150 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P042956
(3 genes in 3 species)
specific family

Descriptions

gene_descr
dopamine receptor D2

Identifiers

Type Value
pidENSP00000438215
HGNC3023
UniprotP14416

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001659
ISS
IEA
Genome Projecttemperature homeostasis
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0001963
IBA
IEA
Genome Projectsynaptic transmission, dopaminergic
GO:0001964
IEA
Genome Projectstartle response
GO:0001975
ISS
IEA
Genome Projectresponse to amphetamine
GO:0001976
ISS
IEA
Genome Projectneurological system process involved in regulation of systemic arterial blood pressure
GO:0002027
ISS
IEA
Genome Projectregulation of heart rate
GO:0002028
ISS
IEA
Genome Projectregulation of sodium ion transport
GO:0002031
IEA
Genome ProjectG-protein coupled receptor internalization
GO:0002052
ISS
IEA
Genome Projectpositive regulation of neuroblast proliferation
GO:0002092
IEA
Genome Projectpositive regulation of receptor internalization
GO:0006874
IC
Genome Projectcellular calcium ion homeostasis
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007186
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007188
IEA
Genome Projectadenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007194
IDA
IEA
Genome Projectnegative regulation of adenylate cyclase activity
GO:0007195
IDA
IEA
Genome Projectadenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212
IEA
Genome Projectdopamine receptor signaling pathway
GO:0007270
ISS
IEA
Genome Projectneuron-neuron synaptic transmission
GO:0007409
ISS
IEA
Genome Projectaxonogenesis
GO:0007416
ISS
IEA
Genome Projectsynapse assembly
GO:0007608
ISS
IEA
Genome Projectsensory perception of smell
GO:0007616
IEA
Genome Projectlong-term memory
GO:0007625
IEA
Genome Projectgrooming behavior
GO:0007626
ISS
IEA
Genome Projectlocomotory behavior
GO:0007628
ISS
IEA
Genome Projectadult walking behavior
GO:0007631
IEA
Genome Projectfeeding behavior
GO:0008104
ISS
IEA
Genome Projectprotein localization
GO:0008285
ISS
IEA
Genome Projectnegative regulation of cell proliferation
GO:0008306
ISS
IEA
Genome Projectassociative learning
GO:0008542
ISS
IEA
Genome Projectvisual learning
GO:0009416
ISS
IEA
Genome Projectresponse to light stimulus
GO:0009636
IBA
IEA
Genome Projectresponse to toxic substance
GO:0010039
IEA
Genome Projectresponse to iron ion
GO:0014059
IBA
IEA
Genome Projectregulation of dopamine secretion
GO:0014854
IEA
Genome Projectresponse to inactivity
GO:0016055
IEA
Genome ProjectWnt signaling pathway
GO:0021756
IEA
Genome Projectstriatum development
GO:0021769
IEA
Genome Projectorbitofrontal cortex development
GO:0021853
ISS
IEA
Genome Projectcerebral cortex GABAergic interneuron migration
GO:0021984
ISS
IEA
Genome Projectadenohypophysis development
GO:0030336
ISS
IEA
Genome Projectnegative regulation of cell migration
GO:0030432
ISS
IEA
Genome Projectperistalsis
GO:0030534
IEA
Genome Projectadult behavior
GO:0030814
IDA
Genome Projectregulation of cAMP metabolic process
GO:0030900
IEA
Genome Projectforebrain development
GO:0031223
IEA
Genome Projectauditory behavior
GO:0032147
IEA
Genome Projectactivation of protein kinase activity
GO:0032228
ISS
IEA
Genome Projectregulation of synaptic transmission, GABAergic
GO:0032467
IMP
Genome Projectpositive regulation of cytokinesis
GO:0032922
ISS
IEA
Genome Projectcircadian regulation of gene expression
GO:0033602
IEA
Genome Projectnegative regulation of dopamine secretion
GO:0034776
IDA
Genome Projectresponse to histamine
GO:0035094
IEA
Genome Projectresponse to nicotine
GO:0035556
IDA
Genome Projectintracellular signal transduction
GO:0035810
IEA
Genome Projectpositive regulation of urine volume
GO:0035815
IEA
Genome Projectpositive regulation of renal sodium excretion
GO:0040018
IEA
Genome Projectpositive regulation of multicellular organism growth
GO:0042220
ISS
IEA
Genome Projectresponse to cocaine
GO:0042321
IEA
Genome Projectnegative regulation of circadian sleep/wake cycle, sleep
GO:0042417
IC, IEA
Genome Projectdopamine metabolic process
GO:0042493
ISS, IBA
IEA
Genome Projectresponse to drug
GO:0043266
ISS, IBA
IEA
Genome Projectregulation of potassium ion transport
GO:0043278
ISS
IEA
Genome Projectresponse to morphine
GO:0043408
IEA
Genome Projectregulation of MAPK cascade
GO:0043473
IEA
Genome Projectpigmentation
GO:0043666
IEA
Genome Projectregulation of phosphoprotein phosphatase activity
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0045745
IEA
Genome Projectpositive regulation of G-protein coupled receptor protein signaling pathway
GO:0045776
ISS
IEA
Genome Projectnegative regulation of blood pressure
GO:0045824
IEA
Genome Projectnegative regulation of innate immune response
GO:0045944
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046488
ISS
IEA
Genome Projectphosphatidylinositol metabolic process
GO:0046676
IEA
Genome Projectnegative regulation of insulin secretion
GO:0046717
IEA
Genome Projectacid secretion
GO:0048148
ISS, IBA
IEA
Genome Projectbehavioral response to cocaine
GO:0048149
ISS, IBA
IEA
Genome Projectbehavioral response to ethanol
GO:0048169
ISS
IEA
Genome Projectregulation of long-term neuronal synaptic plasticity
GO:0048678
IEA
Genome Projectresponse to axon injury
GO:0048755
ISS
IEA
Genome Projectbranching morphogenesis of a nerve
GO:0050482
IDA
Genome Projectarachidonic acid secretion
GO:0050709
IDA
Genome Projectnegative regulation of protein secretion
GO:0050804
IEA
Genome Projectmodulation of synaptic transmission
GO:0051209
ISS
IEA
Genome Projectrelease of sequestered calcium ion into cytosol
GO:0051481
IBA
IEA
Genome Projectnegative regulation of cytosolic calcium ion concentration
GO:0051482
IDA
Genome Projectpositive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051584
IC, IEA
Genome Projectregulation of dopamine uptake involved in synaptic transmission
GO:0051586
ISS
IEA
Genome Projectpositive regulation of dopamine uptake involved in synaptic transmission
GO:0051823
IEA
Genome Projectregulation of synapse structural plasticity
GO:0051898
ISS
IEA
Genome Projectnegative regulation of protein kinase B signaling
GO:0051967
ISS, IBA
IEA
Genome Projectnegative regulation of synaptic transmission, glutamatergic
GO:0060124
ISS
IEA
Genome Projectpositive regulation of growth hormone secretion
GO:0060134
ISS
IEA
Genome Projectprepulse inhibition
GO:0060158
IGI
Genome Projectphospholipase C-activating dopamine receptor signaling pathway
GO:0060160
ISS
IEA
Genome Projectnegative regulation of dopamine receptor signaling pathway
GO:0070374
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0090325
IEA
Genome Projectregulation of locomotion involved in locomotory behavior
GO:1900168
IDA
Genome Projectpositive regulation of glial cell-derived neurotrophic factor secretion
GO:1900273
IEA
Genome Projectpositive regulation of long-term synaptic potentiation
GO:1901386
IDA
IEA
Genome Projectnegative regulation of voltage-gated calcium channel activity
GO:0071880
IBA
Genome Projectadenylate cyclase-activating adrenergic receptor signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001591
IDA
IEA
Genome Projectdopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0004930
IEA
Genome ProjectG-protein coupled receptor activity
GO:0004952
IEA
Genome Projectdopamine neurotransmitter receptor activity
GO:0005102
IEA
Genome Projectreceptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008144
IDA
IEA
Genome Projectdrug binding
GO:0015459
NAS
Genome Projectpotassium channel regulator activity
GO:0035240
IBA
IEA
Genome Projectdopamine binding
GO:0035255
IEA
Genome Projectionotropic glutamate receptor binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042803
IEA
Genome Projectprotein homodimerization activity
GO:0046982
IEA
Genome Projectprotein heterodimerization activity
GO:0004935
IBA
Genome Projectadrenergic receptor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001669
IEA
Genome Projectacrosomal vesicle
GO:0005622
IDA
Genome Projectintracellular
GO:0005829
IDA
IBA
IEA
Genome Projectcytosol
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0005887
IDA
IC, IEA
Genome Projectintegral component of plasma membrane
GO:0014069
IEA
Genome Projectpostsynaptic density
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016328
IEA
Genome Projectlateral plasma membrane
GO:0030139
IEA
Genome Projectendocytic vesicle
GO:0030424
ISS
IEA
Genome Projectaxon
GO:0030425
ISS
IEA
Genome Projectdendrite
GO:0030672
IBA
IEA
Genome Projectsynaptic vesicle membrane
GO:0031410
IEA
Genome Projectcytoplasmic vesicle
GO:0031513
IDA
Genome Projectnonmotile primary cilium
GO:0036126
IEA
Genome Projectsperm flagellum
GO:0043197
IEA
Genome Projectdendritic spine
GO:0043204
IEA
Genome Projectperikaryon
GO:0043679
IEA
Genome Projectaxon terminus
GO:0060170
IDA
Genome Projectciliary membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000276G protein-coupled receptor, rhodopsin-like
IPR000929Dopamine receptor family
IPR001922Dopamine D2 receptor
IPR017452GPCR, rhodopsin-like, 7TM

No MapMan annotations defined for this gene.