Gene: ENSG00000148400 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000148400
Transcript Identifier
ENST00000277541
Gene Type
Coding gene
Location
9 : 136496071-136545786 : negative

Family Information

Homologous gene family
HOM03P000383
(115 genes in 8 species)
specific family
Orthologous gene family
ORTHO03P007396
(11 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
notch 1

Identifiers

Type Value
pidENSP00000277541
HGNC7881
UniprotP46531

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
ISS
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001525
IEA
Genome Projectangiogenesis
GO:0001701
IEA
Genome Projectin utero embryonic development
GO:0001708
IEA
Genome Projectcell fate specification
GO:0001837
ISS
IEA
Genome Projectepithelial to mesenchymal transition
GO:0001889
IEA
Genome Projectliver development
GO:0001947
ISS
IEA
Genome Projectheart looping
GO:0002040
IEA
Genome Projectsprouting angiogenesis
GO:0002052
IEA
Genome Projectpositive regulation of neuroblast proliferation
GO:0002437
IEA
Genome Projectinflammatory response to antigenic stimulus
GO:0003157
ISS
IEA
Genome Projectendocardium development
GO:0003160
ISS
IEA
Genome Projectendocardium morphogenesis
GO:0003162
IEA
Genome Projectatrioventricular node development
GO:0003169
ISS
IEA
Genome Projectcoronary vein morphogenesis
GO:0003180
IMP
Genome Projectaortic valve morphogenesis
GO:0003181
ISS
IEA
Genome Projectatrioventricular valve morphogenesis
GO:0003184
IMP
Genome Projectpulmonary valve morphogenesis
GO:0003192
IMP
Genome Projectmitral valve formation
GO:0003198
ISS
IEA
Genome Projectepithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203
ISS
IEA
Genome Projectendocardial cushion morphogenesis
GO:0003207
ISS
IEA
Genome Projectcardiac chamber formation
GO:0003208
ISS
IEA
Genome Projectcardiac ventricle morphogenesis
GO:0003209
ISS
IEA
Genome Projectcardiac atrium morphogenesis
GO:0003213
ISS
IEA
Genome Projectcardiac right atrium morphogenesis
GO:0003214
ISS
IEA
Genome Projectcardiac left ventricle morphogenesis
GO:0003219
IEA
Genome Projectcardiac right ventricle formation
GO:0003222
ISS
IEA
Genome Projectventricular trabecula myocardium morphogenesis
GO:0003241
ISS
IEA
Genome Projectgrowth involved in heart morphogenesis
GO:0003256
ISS
IEA
Genome Projectregulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003264
IEA
Genome Projectregulation of cardioblast proliferation
GO:0003270
IEA
Genome ProjectNotch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
GO:0003273
ISS
IEA
Genome Projectcell migration involved in endocardial cushion formation
GO:0003344
ISS
IEA
Genome Projectpericardium morphogenesis
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
TAS, IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006357
IEA
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0006367
TAS
Genome Projecttranscription initiation from RNA polymerase II promoter
GO:0006955
NAS
Genome Projectimmune response
GO:0006959
IEA
Genome Projecthumoral immune response
GO:0007219
IMP
TAS, IEA
Genome ProjectNotch signaling pathway
GO:0007220
TAS
Genome ProjectNotch receptor processing
GO:0007221
ISS
IEA
Genome Projectpositive regulation of transcription of Notch receptor target
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007283
IEA
Genome Projectspermatogenesis
GO:0007368
ISS
IEA
Genome Projectdetermination of left/right symmetry
GO:0007386
IEA
Genome Projectcompartment pattern specification
GO:0007409
IEA
Genome Projectaxonogenesis
GO:0007420
IEA
Genome Projectbrain development
GO:0007440
IEA
Genome Projectforegut morphogenesis
GO:0007492
IEA
Genome Projectendoderm development
GO:0007507
IMP
Genome Projectheart development
GO:0008284
IDA, IMP
Genome Projectpositive regulation of cell proliferation
GO:0008285
IDA
Genome Projectnegative regulation of cell proliferation
GO:0008544
IEA
Genome Projectepidermis development
GO:0009912
IEA
Genome Projectauditory receptor cell fate commitment
GO:0010001
IEA
Genome Projectglial cell differentiation
GO:0010467
TAS
Genome Projectgene expression
GO:0010468
IEA
Genome Projectregulation of gene expression
GO:0010718
IMP
Genome Projectpositive regulation of epithelial to mesenchymal transition
GO:0010812
IDA
Genome Projectnegative regulation of cell-substrate adhesion
GO:0010832
ISS
IEA
Genome Projectnegative regulation of myotube differentiation
GO:0014031
ISS
IEA
Genome Projectmesenchymal cell development
GO:0014807
IEA
Genome Projectregulation of somitogenesis
GO:0021515
IEA
Genome Projectcell differentiation in spinal cord
GO:0021915
IEA
Genome Projectneural tube development
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030182
IEA
Genome Projectneuron differentiation
GO:0030216
IEA
Genome Projectkeratinocyte differentiation
GO:0030279
ISS
IEA
Genome Projectnegative regulation of ossification
GO:0030324
IEA
Genome Projectlung development
GO:0030326
IEA
Genome Projectembryonic limb morphogenesis
GO:0030334
IEA
Genome Projectregulation of cell migration
GO:0030335
ISS
IEA
Genome Projectpositive regulation of cell migration
GO:0030513
ISS
IEA
Genome Projectpositive regulation of BMP signaling pathway
GO:0030514
ISS
IEA
Genome Projectnegative regulation of BMP signaling pathway
GO:0030900
IEA
Genome Projectforebrain development
GO:0031069
IEA
Genome Projecthair follicle morphogenesis
GO:0031100
IEA
Genome Projectorgan regeneration
GO:0031960
IEA
Genome Projectresponse to corticosteroid
GO:0032495
IEA
Genome Projectresponse to muramyl dipeptide
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0035116
IEA
Genome Projectembryonic hindlimb morphogenesis
GO:0035148
IMP
Genome Projecttube formation
GO:0035914
IEA
Genome Projectskeletal muscle cell differentiation
GO:0035924
IDA
Genome Projectcellular response to vascular endothelial growth factor stimulus
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0042246
IEA
Genome Projecttissue regeneration
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043086
ISS
IEA
Genome Projectnegative regulation of catalytic activity
GO:0045165
IEA
Genome Projectcell fate commitment
GO:0045596
IEA
Genome Projectnegative regulation of cell differentiation
GO:0045603
IEA
Genome Projectpositive regulation of endothelial cell differentiation
GO:0045618
IEA
Genome Projectpositive regulation of keratinocyte differentiation
GO:0045662
IMP
Genome Projectnegative regulation of myoblast differentiation
GO:0045665
IEA
Genome Projectnegative regulation of neuron differentiation
GO:0045668
ISS
IEA
Genome Projectnegative regulation of osteoblast differentiation
GO:0045687
IEA
Genome Projectpositive regulation of glial cell differentiation
GO:0045892
ISS
IEA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
ISS
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA
ISS
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0045955
IEA
Genome Projectnegative regulation of calcium ion-dependent exocytosis
GO:0046427
ISS
IEA
Genome Projectpositive regulation of JAK-STAT cascade
GO:0046533
IEA
Genome Projectnegative regulation of photoreceptor cell differentiation
GO:0048103
IEA
Genome Projectsomatic stem cell division
GO:0048663
IEA
Genome Projectneuron fate commitment
GO:0048708
IEA
Genome Projectastrocyte differentiation
GO:0048709
IEA
Genome Projectoligodendrocyte differentiation
GO:0048711
ISS
IEA
Genome Projectpositive regulation of astrocyte differentiation
GO:0048715
ISS
IEA
Genome Projectnegative regulation of oligodendrocyte differentiation
GO:0048754
IEA
Genome Projectbranching morphogenesis of an epithelial tube
GO:0050678
IEA
Genome Projectregulation of epithelial cell proliferation
GO:0050679
IEA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050767
IEA
Genome Projectregulation of neurogenesis
GO:0050768
ISS
IEA
Genome Projectnegative regulation of neurogenesis
GO:0050793
IEA
Genome Projectregulation of developmental process
GO:0055008
ISS
IEA
Genome Projectcardiac muscle tissue morphogenesis
GO:0060038
IEA
Genome Projectcardiac muscle cell proliferation
GO:0060045
ISS
IEA
Genome Projectpositive regulation of cardiac muscle cell proliferation
GO:0060253
ISS
IEA
Genome Projectnegative regulation of glial cell proliferation
GO:0060271
ISS
Genome Projectcilium morphogenesis
GO:0060317
ISS
IEA
Genome Projectcardiac epithelial to mesenchymal transition
GO:0060411
ISS
IEA
Genome Projectcardiac septum morphogenesis
GO:0060412
IMP
Genome Projectventricular septum morphogenesis
GO:0060528
IEA
Genome Projectsecretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060548
IEA
Genome Projectnegative regulation of cell death
GO:0060740
IEA
Genome Projectprostate gland epithelium morphogenesis
GO:0060768
IEA
Genome Projectregulation of epithelial cell proliferation involved in prostate gland development
GO:0060842
ISS
IEA
Genome Projectarterial endothelial cell differentiation
GO:0060843
ISS
IEA
Genome Projectvenous endothelial cell differentiation
GO:0060948
ISS
IEA
Genome Projectcardiac vascular smooth muscle cell development
GO:0060956
ISS
IEA
Genome Projectendocardial cell differentiation
GO:0060979
ISS
IEA
Genome Projectvasculogenesis involved in coronary vascular morphogenesis
GO:0060982
ISS
IEA
Genome Projectcoronary artery morphogenesis
GO:0061314
IMP
Genome ProjectNotch signaling involved in heart development
GO:0061384
ISS
IEA
Genome Projectheart trabecula morphogenesis
GO:0061419
ISS
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070986
IEA
Genome Projectleft/right axis specification
GO:0071372
IDA
Genome Projectcellular response to follicle-stimulating hormone stimulus
GO:0072017
IEA
Genome Projectdistal tubule development
GO:0072044
IEA
Genome Projectcollecting duct development
GO:0072144
IEA
Genome Projectglomerular mesangial cell development
GO:0072602
IEA
Genome Projectinterleukin-4 secretion
GO:0090051
IDA
Genome Projectnegative regulation of cell migration involved in sprouting angiogenesis
GO:0090090
IEA
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0097150
IEP
Genome Projectneuronal stem cell population maintenance
GO:1901201
ISS
IEA
Genome Projectregulation of extracellular matrix assembly
GO:1902263
IEA
Genome Projectapoptotic process involved in embryonic digit morphogenesis
GO:2000737
IMP
Genome Projectnegative regulation of stem cell differentiation
GO:2000811
IMP
Genome Projectnegative regulation of anoikis
GO:2000974
ISS
IEA
Genome Projectnegative regulation of pro-B cell differentiation
GO:2001027
IDA
Genome Projectnegative regulation of endothelial cell chemotaxis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001047
ISS
IEA
Genome Projectcore promoter binding
GO:0001190
ISS
IEA
Genome Projecttranscriptional activator activity, RNA polymerase II transcription factor binding
GO:0003682
IEA
Genome Projectchromatin binding
GO:0003700
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0004857
ISS
IEA
Genome Projectenzyme inhibitor activity
GO:0004872
IEA
Genome Projectreceptor activity
GO:0005509
IEA
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0019899
ISS
IEA
Genome Projectenzyme binding
GO:0031490
IEA
Genome Projectchromatin DNA binding
GO:0043565
IEA
Genome Projectsequence-specific DNA binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000139
TAS
Genome ProjectGolgi membrane
GO:0001669
IEA
Genome Projectacrosomal vesicle
GO:0002193
IDA
Genome ProjectMAML1-RBP-Jkappa- ICN1 complex
GO:0005576
TAS
Genome Projectextracellular region
GO:0005634
ISS
TAS, IEA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005789
TAS
Genome Projectendoplasmic reticulum membrane
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0009986
IEA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0043235
IDA
Genome Projectreceptor complex
GO:0071944
IEA
Genome Projectcell periphery

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000152EGF-type aspartate/asparagine hydroxylation site
IPR000742EGF-like domain
IPR000800Notch domain
IPR001881EGF-like calcium-binding domain
IPR002110Ankyrin repeat
IPR008297Notch
IPR009030Growth factor receptor cysteine-rich domain
IPR010660Notch, NOD domain
IPR011656Notch, NODP domain
IPR013032EGF-like, conserved site
IPR018097EGF-like calcium-binding, conserved site
IPR020683Ankyrin repeat-containing domain
IPR022362Neurogenic locus Notch 1
IPR024600Domain of unknown function DUF3454, notch

No MapMan annotations defined for this gene.