Gene: ENSG00000148180 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000148180
Transcript Identifier
ENST00000373818
Gene Type
Coding gene
Location
9 : 121299862-121332603 : positive

Family Information

Homologous gene family
HOM03P000775
(73 genes in 23 species)
specific family
Orthologous gene family
ORTHO03P000870
(42 genes in 21 species)
specific family

Descriptions

gene_descr
gelsolin

Identifiers

Type Value
pidENSP00000362924
HGNC4620
UniprotP06396

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006911
ISS
IEA
Genome Projectphagocytosis, engulfment
GO:0006915
TAS, IEA
Genome Projectapoptotic process
GO:0006921
TAS
Genome Projectcellular component disassembly involved in execution phase of apoptosis
GO:0007568
IEA
Genome Projectaging
GO:0008154
IEA
Genome Projectactin polymerization or depolymerization
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0014003
IEA
Genome Projectoligodendrocyte development
GO:0014891
IMP
Genome Projectstriated muscle atrophy
GO:0016192
IEA
Genome Projectvesicle-mediated transport
GO:0030030
IEA
Genome Projectcell projection organization
GO:0030041
IDA, IMP
ISS
Genome Projectactin filament polymerization
GO:0030155
IEA
Genome Projectregulation of cell adhesion
GO:0031648
IMP
Genome Projectprotein destabilization
GO:0042060
IEA
Genome Projectwound healing
GO:0042246
IEA
Genome Projecttissue regeneration
GO:0042989
IMP
Genome Projectsequestering of actin monomers
GO:0045010
IEA
Genome Projectactin nucleation
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0046597
IMP
Genome Projectnegative regulation of viral entry into host cell
GO:0048015
IEA
Genome Projectphosphatidylinositol-mediated signaling
GO:0051014
IDA, IMP
ISS
IEA
Genome Projectactin filament severing
GO:0051016
TAS, IEA
Genome Projectbarbed-end actin filament capping
GO:0051127
IMP
Genome Projectpositive regulation of actin nucleation
GO:0051593
IEA
Genome Projectresponse to folic acid
GO:0051693
IMP
ISS
IEA
Genome Projectactin filament capping
GO:0060271
IMP
Genome Projectcilium morphogenesis
GO:0071276
IEA
Genome Projectcellular response to cadmium ion
GO:0071801
IMP
Genome Projectregulation of podosome assembly
GO:0090527
IGI
Genome Projectactin filament reorganization
GO:0097017
IMP
Genome Projectrenal protein absorption
GO:0097284
IMP
Genome Projecthepatocyte apoptotic process
GO:1902174
IMP
Genome Projectpositive regulation of keratinocyte apoptotic process
GO:1903689
IMP, IGI
Genome Projectregulation of wound healing, spreading of epidermal cells
GO:1903903
IMP
Genome Projectregulation of establishment of T cell polarity
GO:1903906
IMP
Genome Projectregulation of plasma membrane raft polarization
GO:1903909
IMP
Genome Projectregulation of receptor clustering
GO:1903923
ISS
IEA
Genome Projectpositive regulation of protein processing in phagocytic vesicle
GO:1990000
IMP
Genome Projectamyloid fibril formation
GO:2001269
IMP
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0022617
IMP
Genome Projectextracellular matrix disassembly

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003779
IDA
IEA
Genome Projectactin binding
GO:0005509
IMP
TAS, IEA
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0019904
IPI
Genome Projectprotein domain specific binding
GO:0045159
IPI
Genome Projectmyosin II binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001726
IEA
Genome Projectruffle
GO:0002102
IDA
Genome Projectpodosome
GO:0005576
IDA
ISS
TAS, NAS, IEA
Genome Projectextracellular region
GO:0005615
IDA
IEA
Genome Projectextracellular space
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
IDA
ISS
TAS
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0015629
TAS, IEA
Genome Projectactin cytoskeleton
GO:0016528
IDA
Genome Projectsarcoplasm
GO:0030027
IEA
Genome Projectlamellipodium
GO:0030478
IDA
Genome Projectactin cap
GO:0030864
IDA
Genome Projectcortical actin cytoskeleton
GO:0043209
IEA
Genome Projectmyelin sheath
GO:0043234
IEA
Genome Projectprotein complex
GO:0048471
IEA
Genome Projectperinuclear region of cytoplasm
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0072562
IDA
Genome Projectblood microparticle
GO:0005634
IDA
Genome Projectnucleus

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR007122Villin/Gelsolin
IPR007123Gelsolin-like domain
IPR029006ADF-H/Gelsolin-like domain
IPR030004Gelsolin

No MapMan annotations defined for this gene.