Gene: ENSG00000146648 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000146648
Transcript Identifier
ENST00000275493
Gene Type
Coding gene
Location
7 : 55019278-55205617 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P009161
(9 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
epidermal growth factor receptor

Identifiers

Type Value
pidENSP00000275493
HGNC3236
UniprotP00533

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
NAS
Genome ProjectMAPK cascade
GO:0000186
NAS
Genome Projectactivation of MAPKK activity
GO:0000902
IEA
Genome Projectcell morphogenesis
GO:0001503
NAS
Genome Projectossification
GO:0001892
IEA
Genome Projectembryonic placenta development
GO:0001934
IDA
Genome Projectpositive regulation of protein phosphorylation
GO:0001942
IEA
Genome Projecthair follicle development
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0006950
NAS
Genome Projectresponse to stress
GO:0007165
IDA
TAS
Genome Projectsignal transduction
GO:0007166
IDA
Genome Projectcell surface receptor signaling pathway
GO:0007169
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173
IDA
TAS, IEA
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007202
TAS
Genome Projectactivation of phospholipase C activity
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007411
TAS
Genome Projectaxon guidance
GO:0007435
IEA
Genome Projectsalivary gland morphogenesis
GO:0007611
ISS
IEA
Genome Projectlearning or memory
GO:0008283
IDA
Genome Projectcell proliferation
GO:0008284
IDA
Genome Projectpositive regulation of cell proliferation
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0008544
IEA
Genome Projectepidermis development
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016337
IMP
Genome Projectsingle organismal cell-cell adhesion
GO:0018108
IDA, IMP
TAS, IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0021795
IEA
Genome Projectcerebral cortex cell migration
GO:0023014
IEA
Genome Projectsignal transduction by protein phosphorylation
GO:0030335
IMP
Genome Projectpositive regulation of cell migration
GO:0031659
IDA
Genome Projectpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0035413
IMP
Genome Projectpositive regulation of catenin import into nucleus
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0042059
TAS
Genome Projectnegative regulation of epidermal growth factor receptor signaling pathway
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0042177
IDA
Genome Projectnegative regulation of protein catabolic process
GO:0042327
IDA
Genome Projectpositive regulation of phosphorylation
GO:0043006
TAS
Genome Projectactivation of phospholipase A2 activity by calcium-mediated signaling
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043406
IDA
Genome Projectpositive regulation of MAP kinase activity
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045429
IDA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045739
IDA
Genome Projectpositive regulation of DNA repair
GO:0045740
IDA
Genome Projectpositive regulation of DNA replication
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046777
IMP
Genome Projectprotein autophosphorylation
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048015
TAS
Genome Projectphosphatidylinositol-mediated signaling
GO:0048146
IEA
Genome Projectpositive regulation of fibroblast proliferation
GO:0048546
IEA
Genome Projectdigestive tract morphogenesis
GO:0050679
IDA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050730
IMP
Genome Projectregulation of peptidyl-tyrosine phosphorylation
GO:0050999
IDA
Genome Projectregulation of nitric-oxide synthase activity
GO:0051205
TAS
Genome Projectprotein insertion into membrane
GO:0051897
IMP
Genome Projectpositive regulation of protein kinase B signaling
GO:0060571
IEA
Genome Projectmorphogenesis of an epithelial fold
GO:0070141
IDA
Genome Projectresponse to UV-A
GO:0070374
IDA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0071230
IEA
Genome Projectcellular response to amino acid stimulus
GO:0071364
ISS
IEA
Genome Projectcellular response to epidermal growth factor stimulus
GO:0071392
IDA
Genome Projectcellular response to estradiol stimulus

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0003682
IDA
Genome Projectchromatin binding
GO:0003690
NAS
Genome Projectdouble-stranded DNA binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004709
NAS
Genome ProjectMAP kinase kinase kinase activity
GO:0004713
IDA, IMP
TAS, IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
TAS, IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0004716
IEA
Genome Projectreceptor signaling protein tyrosine kinase activity
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0004888
IDA
Genome Projecttransmembrane signaling receptor activity
GO:0005006
IDA
NAS
Genome Projectepidermal growth factor-activated receptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019903
IPI
Genome Projectprotein phosphatase binding
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0046982
IDA
Genome Projectprotein heterodimerization activity
GO:0051015
IDA
Genome Projectactin filament binding
GO:0030235
IDA
Genome Projectnitric-oxide synthase regulator activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000139
IEA
Genome ProjectGolgi membrane
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
NAS
Genome Projectextracellular space
GO:0005622
IEA
Genome Projectintracellular
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005768
IDA
IEA
Genome Projectendosome
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005789
IEA
Genome Projectendoplasmic reticulum membrane
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0009986
IDA
IEA
Genome Projectcell surface
GO:0010008
IDA
IEA
Genome Projectendosome membrane
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016323
IDA
Genome Projectbasolateral plasma membrane
GO:0030139
IEA
Genome Projectendocytic vesicle
GO:0031901
IDA
Genome Projectearly endosome membrane
GO:0031965
IEA
Genome Projectnuclear membrane
GO:0043235
IDA
Genome Projectreceptor complex
GO:0045121
IDA
Genome Projectmembrane raft
GO:0048471
IEA
Genome Projectperinuclear region of cytoplasm
GO:0070435
ISS
Genome ProjectShc-EGFR complex
GO:0097489
IDA
Genome Projectmultivesicular body, internal vesicle lumen
GO:0030122
TAS
Genome ProjectAP-2 adaptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000494Receptor L-domain
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR006211Furin-like cysteine-rich domain
IPR006212Furin-like repeat
IPR008266Tyrosine-protein kinase, active site
IPR009030Growth factor receptor cysteine-rich domain
IPR011009Protein kinase-like domain
IPR016245Tyrosine protein kinase, EGF/ERB/XmrK receptor
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.