Gene: ENSG00000145675 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000145675
Transcript Identifier
ENST00000521657
Gene Type
Coding gene
Location
5 : 68226676-68297601 : positive

Family Information

Homologous gene family
HOM03P008093
(10 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P010275
(8 genes in 4 species)
specific family

Descriptions

gene_descr
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Identifiers

Type Value
pidENSP00000429277
HGNC8979
UniprotP27986

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001678
ISS
IEA
Genome Projectcellular glucose homeostasis
GO:0001953
IEA
Genome Projectnegative regulation of cell-matrix adhesion
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0006644
TAS
Genome Projectphospholipid metabolic process
GO:0006661
TAS
Genome Projectphosphatidylinositol biosynthetic process
GO:0006810
IEA
Genome Projecttransport
GO:0007162
IEA
Genome Projectnegative regulation of cell adhesion
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008286
IBA
TAS
Genome Projectinsulin receptor signaling pathway
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0008625
IEA
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0008630
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0014065
IDA
Genome Projectphosphatidylinositol 3-kinase signaling
GO:0015031
IEA
Genome Projectprotein transport
GO:0016032
IEA
Genome Projectviral process
GO:0030168
TAS
Genome Projectplatelet activation
GO:0030183
IEA
Genome ProjectB cell differentiation
GO:0030335
IEA
Genome Projectpositive regulation of cell migration
GO:0031295
TAS
Genome ProjectT cell costimulation
GO:0032760
IEA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032869
ISS
IEA
Genome Projectcellular response to insulin stimulus
GO:0033120
IMP
Genome Projectpositive regulation of RNA splicing
GO:0034644
IEA
Genome Projectcellular response to UV
GO:0034976
IDA
ISS
Genome Projectresponse to endoplasmic reticulum stress
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038096
TAS
Genome ProjectFc-gamma receptor signaling pathway involved in phagocytosis
GO:0042993
IDA
ISS
Genome Projectpositive regulation of transcription factor import into nucleus
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043551
ISS, IBA
Genome Projectregulation of phosphatidylinositol 3-kinase activity
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045671
IEA
Genome Projectnegative regulation of osteoclast differentiation
GO:0045944
IMP
ISS
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046326
ISS
Genome Projectpositive regulation of glucose import
GO:0046854
ISS, IBA
Genome Projectphosphatidylinositol phosphorylation
GO:0048009
IDA, IPI
Genome Projectinsulin-like growth factor receptor signaling pathway
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048015
TAS
Genome Projectphosphatidylinositol-mediated signaling
GO:0050821
IDA
Genome Projectprotein stabilization
GO:0050852
TAS
Genome ProjectT cell receptor signaling pathway
GO:0050900
TAS
Genome Projectleukocyte migration
GO:0051492
IEA
Genome Projectregulation of stress fiber assembly
GO:0051531
IEA
Genome ProjectNFAT protein import into nucleus
GO:0060396
IDA
Genome Projectgrowth hormone receptor signaling pathway
GO:0090003
IEA
Genome Projectregulation of establishment of protein localization to plasma membrane
GO:0090004
ISS
Genome Projectpositive regulation of establishment of protein localization to plasma membrane
GO:1900103
IMP
Genome Projectpositive regulation of endoplasmic reticulum unfolded protein response
GO:2001275
ISS
Genome Projectpositive regulation of glucose import in response to insulin stimulus

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005068
ISS
Genome Projecttransmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158
IPI
Genome Projectinsulin receptor binding
GO:0005159
IPI
Genome Projectinsulin-like growth factor receptor binding
GO:0005168
IPI
Genome Projectneurotrophin TRKA receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0019903
IPI
Genome Projectprotein phosphatase binding
GO:0035014
ISS
IEA
Genome Projectphosphatidylinositol 3-kinase regulator activity
GO:0036312
IEA
Genome Projectphosphatidylinositol 3-kinase regulatory subunit binding
GO:0043125
IDA
Genome ProjectErbB-3 class receptor binding
GO:0043548
ISS
Genome Projectphosphatidylinositol 3-kinase binding
GO:0043559
IDA
Genome Projectinsulin binding
GO:0043560
ISS
IEA
Genome Projectinsulin receptor substrate binding
GO:0046935
IBA
Genome Project1-phosphatidylinositol-3-kinase regulator activity
GO:0046982
IEA
Genome Projectprotein heterodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
ISS
IEA
Genome Projectnucleus
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005801
IEA
Genome Projectcis-Golgi network
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0005886
TAS
Genome Projectplasma membrane
GO:0005911
IEA
Genome Projectcell-cell junction
GO:0005942
ISS, IBA
IEA
Genome Projectphosphatidylinositol 3-kinase complex
GO:0005943
ISS
Genome Projectphosphatidylinositol 3-kinase complex, class IA
GO:0016020
IDA
Genome Projectmembrane
GO:1990578
IEA
Genome Projectperinuclear endoplasmic reticulum membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000198Rho GTPase-activating protein domain
IPR000980SH2 domain
IPR001452SH3 domain
IPR001720PI3K p85 subunit
IPR008936Rho GTPase activation protein
IPR032498PI3K p85 subunit, inter-SH2 domain

No MapMan annotations defined for this gene.