Gene: ENSG00000145423 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000145423
Transcript Identifier
ENST00000274063
Gene Type
Coding gene
Location
4 : 153781451-153788835 : negative

Family Information

Homologous gene family
HOM03P002165
(40 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P074891
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
secreted frizzled-related protein 2

Identifiers

Type Value
pidENSP00000274063
HGNC10777
UniprotQ96HF1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001569
ISS
IEA
Genome Projectpatterning of blood vessels
GO:0001756
IEA
Genome Projectsomitogenesis
GO:0001843
IEA
Genome Projectneural tube closure
GO:0002063
IEA
Genome Projectchondrocyte development
GO:0003151
IMP
Genome Projectoutflow tract morphogenesis
GO:0003214
IMP
Genome Projectcardiac left ventricle morphogenesis
GO:0006915
IEA
Genome Projectapoptotic process
GO:0007267
ISS
Genome Projectcell-cell signaling
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007584
IEA
Genome Projectresponse to nutrient
GO:0008284
IDA
Genome Projectpositive regulation of cell proliferation
GO:0008285
IDA, IMP
Genome Projectnegative regulation of cell proliferation
GO:0008584
IEA
Genome Projectmale gonad development
GO:0009952
IEA
Genome Projectanterior/posterior pattern specification
GO:0010629
ISS
IEA
Genome Projectnegative regulation of gene expression
GO:0010667
IEA
Genome Projectnegative regulation of cardiac muscle cell apoptotic process
GO:0010719
IDA
Genome Projectnegative regulation of epithelial to mesenchymal transition
GO:0010950
IEA
Genome Projectpositive regulation of endopeptidase activity
GO:0016055
IEA
Genome ProjectWnt signaling pathway
GO:0021915
IEA
Genome Projectneural tube development
GO:0030111
IEA
Genome Projectregulation of Wnt signaling pathway
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030178
IDA
Genome Projectnegative regulation of Wnt signaling pathway
GO:0030199
IEA
Genome Projectcollagen fibril organization
GO:0030307
ISS
IEA
Genome Projectpositive regulation of cell growth
GO:0030308
IDA
Genome Projectnegative regulation of cell growth
GO:0030336
ISS
IEA
Genome Projectnegative regulation of cell migration
GO:0030514
IEA
Genome Projectnegative regulation of BMP signaling pathway
GO:0031668
IEA
Genome Projectcellular response to extracellular stimulus
GO:0033138
ISS
IEA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0033630
ISS
Genome Projectpositive regulation of cell adhesion mediated by integrin
GO:0035413
IEA
Genome Projectpositive regulation of catenin import into nucleus
GO:0035567
IBA
Genome Projectnon-canonical Wnt signaling pathway
GO:0036342
IEA
Genome Projectpost-anal tail morphogenesis
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042662
IEA
Genome Projectnegative regulation of mesodermal cell fate specification
GO:0042733
IEA
Genome Projectembryonic digit morphogenesis
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043065
IMP
Genome Projectpositive regulation of apoptotic process
GO:0043154
IEA
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043508
IEA
Genome Projectnegative regulation of JUN kinase activity
GO:0045600
IDA
Genome Projectpositive regulation of fat cell differentiation
GO:0045669
IEA
Genome Projectpositive regulation of osteoblast differentiation
GO:0045766
ISS
IEA
Genome Projectpositive regulation of angiogenesis
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045944
ISS
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046546
IEA
Genome Projectdevelopment of primary male sexual characteristics
GO:0048546
IEA
Genome Projectdigestive tract morphogenesis
GO:0050680
IDA
Genome Projectnegative regulation of epithelial cell proliferation
GO:0050732
ISS
IEA
Genome Projectnegative regulation of peptidyl-tyrosine phosphorylation
GO:0051216
IEA
Genome Projectcartilage development
GO:0060028
IEA
Genome Projectconvergent extension involved in axis elongation
GO:0060070
IBA
Genome Projectcanonical Wnt signaling pathway
GO:0060349
IEA
Genome Projectbone morphogenesis
GO:0061056
ISS
IEA
Genome Projectsclerotome development
GO:0061185
ISS
IEA
Genome Projectnegative regulation of dermatome development
GO:0071425
ISS
IEA
Genome Projecthematopoietic stem cell proliferation
GO:0071481
IEA
Genome Projectcellular response to X-ray
GO:0090090
IDA
TAS
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090175
IEA
Genome Projectregulation of establishment of planar polarity
GO:0090179
IEA
Genome Projectplanar cell polarity pathway involved in neural tube closure
GO:0090244
IEA
Genome ProjectWnt signaling pathway involved in somitogenesis
GO:0090263
ISS
IEA
Genome Projectpositive regulation of canonical Wnt signaling pathway
GO:1902042
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902230
ISS
Genome Projectnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000035
ISS
IEA
Genome Projectregulation of stem cell division
GO:2000041
IEA
Genome Projectnegative regulation of planar cell polarity pathway involved in axis elongation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001968
ISS
Genome Projectfibronectin binding
GO:0005178
ISS
Genome Projectintegrin binding
GO:0010577
IEA
Genome Projectmetalloenzyme activator activity
GO:0017147
IBA
IEA
Genome ProjectWnt-protein binding
GO:0048018
ISS
IEA
Genome Projectreceptor agonist activity
GO:0061133
IEA
Genome Projectendopeptidase activator activity
GO:0004930
IBA
Genome ProjectG-protein coupled receptor activity
GO:0042813
IBA
Genome ProjectWnt-activated receptor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
IDA
ISS
Genome Projectextracellular space
GO:0031012
ISS
Genome Projectextracellular matrix
GO:0016021
IBA
Genome Projectintegral component of membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001134Netrin domain
IPR008993Tissue inhibitor of metalloproteinases-like, OB-fold
IPR015526Frizzled/secreted frizzled-related protein
IPR018933Netrin module, non-TIMP type
IPR020067Frizzled domain
IPR026558Secreted frizzled-related protein 2

No MapMan annotations defined for this gene.