Gene: ENSG00000145335 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000145335
Transcript Identifier
ENST00000506244
Gene Type
Coding gene
Location
4 : 89726628-89835667 : negative

Family Information

Homologous gene family
HOM03P013223
(6 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P071193
(2 genes in 2 species)
specific family

Descriptions

gene_descr
synuclein, alpha (non A4 component of amyloid precursor)

Identifiers

Type Value
pidENSP00000422238
HGNC11138
UniprotP37840

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
TAS
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001774
TAS, IEA
Genome Projectmicroglial cell activation
GO:0001921
IDA
Genome Projectpositive regulation of receptor recycling
GO:0001933
IEA
Genome Projectnegative regulation of protein phosphorylation
GO:0001956
IEA
Genome Projectpositive regulation of neurotransmitter secretion
GO:0001963
IEA
Genome Projectsynaptic transmission, dopaminergic
GO:0006631
IEA
Genome Projectfatty acid metabolic process
GO:0006638
IEA
Genome Projectneutral lipid metabolic process
GO:0006644
IEA
Genome Projectphospholipid metabolic process
GO:0006919
IDA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007006
IEA
Genome Projectmitochondrial membrane organization
GO:0007268
IEA
Genome Projectsynaptic transmission
GO:0007568
IEA
Genome Projectaging
GO:0008344
IEA
Genome Projectadult locomotory behavior
GO:0010040
IDA
Genome Projectresponse to iron(II) ion
GO:0010517
IDA
Genome Projectregulation of phospholipase activity
GO:0010642
IDA
Genome Projectnegative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014048
IEA
Genome Projectregulation of glutamate secretion
GO:0014059
TAS, IEA
Genome Projectregulation of dopamine secretion
GO:0031115
IDA
Genome Projectnegative regulation of microtubule polymerization
GO:0031623
IDA
Genome Projectreceptor internalization
GO:0031648
IDA
Genome Projectprotein destabilization
GO:0032026
IDA
Genome Projectresponse to magnesium ion
GO:0032410
IDA
Genome Projectnegative regulation of transporter activity
GO:0032496
IDA
Genome Projectresponse to lipopolysaccharide
GO:0032769
IDA
Genome Projectnegative regulation of monooxygenase activity
GO:0033138
ISS
IEA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0034341
IDA
Genome Projectresponse to interferon-gamma
GO:0034599
IC, IEA
Genome Projectcellular response to oxidative stress
GO:0035067
IDA
Genome Projectnegative regulation of histone acetylation
GO:0040012
IEA
Genome Projectregulation of locomotion
GO:0042220
IEA
Genome Projectresponse to cocaine
GO:0042416
TAS, IEA
Genome Projectdopamine biosynthetic process
GO:0042417
IEA
Genome Projectdopamine metabolic process
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042775
IEA
Genome Projectmitochondrial ATP synthesis coupled electron transport
GO:0043030
IEA
Genome Projectregulation of macrophage activation
GO:0043065
TAS
Genome Projectpositive regulation of apoptotic process
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043154
IMP
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043206
TAS
Genome Projectextracellular fibril organization
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0044344
IEA
Genome Projectcellular response to fibroblast growth factor stimulus
GO:0045807
IDA
Genome Projectpositive regulation of endocytosis
GO:0045920
IMP
Genome Projectnegative regulation of exocytosis
GO:0045963
IEA
Genome Projectnegative regulation of dopamine metabolic process
GO:0046928
IEA
Genome Projectregulation of neurotransmitter secretion
GO:0048148
IEA
Genome Projectbehavioral response to cocaine
GO:0048168
IEA
Genome Projectregulation of neuronal synaptic plasticity
GO:0048169
IEA
Genome Projectregulation of long-term neuronal synaptic plasticity
GO:0048488
ISS
IEA
Genome Projectsynaptic vesicle endocytosis
GO:0048489
IEA
Genome Projectsynaptic vesicle transport
GO:0050806
IEA
Genome Projectpositive regulation of synaptic transmission
GO:0050808
IEA
Genome Projectsynapse organization
GO:0050812
IEA
Genome Projectregulation of acyl-CoA biosynthetic process
GO:0051281
IDA
Genome Projectpositive regulation of release of sequestered calcium ion into cytosol
GO:0051583
TAS
Genome Projectdopamine uptake involved in synaptic transmission
GO:0051585
IDA
Genome Projectnegative regulation of dopamine uptake involved in synaptic transmission
GO:0051612
IDA
Genome Projectnegative regulation of serotonin uptake
GO:0051622
IDA
Genome Projectnegative regulation of norepinephrine uptake
GO:0055114
IDA
Genome Projectoxidation-reduction process
GO:0060079
IEA
Genome Projectexcitatory postsynaptic potential
GO:0060291
IEA
Genome Projectlong-term synaptic potentiation
GO:0060732
IDA
Genome Projectpositive regulation of inositol phosphate biosynthetic process
GO:0061024
IEA
Genome Projectmembrane organization
GO:0070495
IDA
Genome Projectnegative regulation of thrombin receptor signaling pathway
GO:0070555
IDA
Genome Projectresponse to interleukin-1
GO:0071280
IDA
Genome Projectcellular response to copper ion
GO:0071872
TAS
Genome Projectcellular response to epinephrine stimulus
GO:0071902
IDA
Genome Projectpositive regulation of protein serine/threonine kinase activity
GO:1901214
IEA
Genome Projectregulation of neuron death
GO:1902957
TAS
Genome Projectnegative regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903284
IDA
Genome Projectpositive regulation of glutathione peroxidase activity
GO:1903285
IDA
Genome Projectpositive regulation of hydrogen peroxide catabolic process
GO:1903421
TAS
Genome Projectregulation of synaptic vesicle recycling
GO:1903426
TAS
Genome Projectregulation of reactive oxygen species biosynthetic process
GO:2000377
IEA
Genome Projectregulation of reactive oxygen species metabolic process
GO:0055074
IDA
Genome Projectcalcium ion homeostasis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000287
IDA
Genome Projectmagnesium ion binding
GO:0005507
IDA
Genome Projectcopper ion binding
GO:0005509
IDA
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005543
IDA
IEA
Genome Projectphospholipid binding
GO:0008017
IEA
Genome Projectmicrotubule binding
GO:0008198
IDA
Genome Projectferrous iron binding
GO:0008270
IDA
Genome Projectzinc ion binding
GO:0016491
IDA
Genome Projectoxidoreductase activity
GO:0019894
IPI
Genome Projectkinesin binding
GO:0019899
IEA
Genome Projectenzyme binding
GO:0019904
IEA
Genome Projectprotein domain specific binding
GO:0042393
IDA
Genome Projecthistone binding
GO:0042802
IDA, IPI
Genome Projectidentical protein binding
GO:0043014
IPI
Genome Projectalpha-tubulin binding
GO:0043027
IDA
Genome Projectcysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043274
IEA
Genome Projectphospholipase binding
GO:0044212
TAS
Genome Projecttranscription regulatory region DNA binding
GO:0045502
IPI
Genome Projectdynein binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0047485
IEA
Genome Projectprotein N-terminus binding
GO:0048156
IDA
Genome Projecttau protein binding
GO:0048487
IEA
Genome Projectbeta-tubulin binding
GO:0051219
IDA
Genome Projectphosphoprotein binding
GO:0005504
IDA
Genome Projectfatty acid binding
GO:0060961
IDA
Genome Projectphospholipase D inhibitor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005615
IDA
Genome Projectextracellular space
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005640
IEA
Genome Projectnuclear outer membrane
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005739
TAS, IEA
Genome Projectmitochondrion
GO:0005764
TAS
Genome Projectlysosome
GO:0005791
IEA
Genome Projectrough endoplasmic reticulum
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0005829
IDA
IEA
Genome Projectcytosol
GO:0005840
IEA
Genome Projectribosome
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005886
IDA
IEA
Genome Projectplasma membrane
GO:0005938
IDA
Genome Projectcell cortex
GO:0008021
IEA
Genome Projectsynaptic vesicle
GO:0015629
IDA
Genome Projectactin cytoskeleton
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0016234
IDA
Genome Projectinclusion body
GO:0030054
IEA
Genome Projectcell junction
GO:0030424
IDA
Genome Projectaxon
GO:0030426
IDA
IEA
Genome Projectgrowth cone
GO:0030659
IEA
Genome Projectcytoplasmic vesicle membrane
GO:0043195
IEA
Genome Projectterminal bouton
GO:0043205
IDA
Genome Projectfibril
GO:0043231
IEA
Genome Projectintracellular membrane-bounded organelle
GO:0043679
IEA
Genome Projectaxon terminus
GO:0045202
IEA
Genome Projectsynapse
GO:0048471
IDA
Genome Projectperinuclear region of cytoplasm
GO:0005747
TAS
Genome Projectmitochondrial respiratory chain complex I
GO:0031092
IDA
Genome Projectplatelet alpha granule membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001058Synuclein
IPR002460Alpha-synuclein

No MapMan annotations defined for this gene.