Gene: ENSG00000142627 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000142627
Transcript Identifier
ENST00000358432
Gene Type
Coding gene
Location
1 : 16125215-16155932 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P003318
(24 genes in 4 species)
specific family

Descriptions

gene_descr
EPH receptor A2

Identifiers

Type Value
pidENSP00000351209
HGNC3386
UniprotP29317
UniprotA0A024QZA8

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001501
IEA
Genome Projectskeletal system development
GO:0001568
IEA
Genome Projectblood vessel development
GO:0001570
IEA
Genome Projectvasculogenesis
GO:0001649
ISS
IEA
Genome Projectosteoblast differentiation
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007169
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0014028
IEA
Genome Projectnotochord formation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IDA
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0021915
IEA
Genome Projectneural tube development
GO:0030182
IEA
Genome Projectneuron differentiation
GO:0030316
ISS
IEA
Genome Projectosteoclast differentiation
GO:0033598
ISS
IEA
Genome Projectmammary gland epithelial cell proliferation
GO:0036342
IEA
Genome Projectpost-anal tail morphogenesis
GO:0043535
ISS
IEA
Genome Projectregulation of blood vessel endothelial cell migration
GO:0045765
ISS
IEA
Genome Projectregulation of angiogenesis
GO:0046849
ISS
IEA
Genome Projectbone remodeling
GO:0048013
IDA
TAS, IEA
Genome Projectephrin receptor signaling pathway
GO:0048320
IEA
Genome Projectaxial mesoderm formation
GO:0048570
IEA
Genome Projectnotochord morphogenesis
GO:0060035
IEA
Genome Projectnotochord cell development
GO:0060444
ISS
IEA
Genome Projectbranching involved in mammary gland duct morphogenesis
GO:0070309
ISS
IEA
Genome Projectlens fiber cell morphogenesis
GO:0001525
IEA
Genome Projectangiogenesis
GO:0006915
IEA
Genome Projectapoptotic process
GO:0007155
IEA
Genome Projectcell adhesion
GO:0007275
TAS
Genome Projectmulticellular organismal development
GO:0007411
TAS
Genome Projectaxon guidance
GO:0008630
IDA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0010591
IMP
Genome Projectregulation of lamellipodium assembly
GO:0016032
IEA
Genome Projectviral process
GO:0016477
IMP
Genome Projectcell migration
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030216
IMP
Genome Projectkeratinocyte differentiation
GO:0033628
IDA
Genome Projectregulation of cell adhesion mediated by integrin
GO:0043491
IDA
Genome Projectprotein kinase B signaling
GO:0051898
IDA
Genome Projectnegative regulation of protein kinase B signaling
GO:0060326
IMP
Genome Projectcell chemotaxis
GO:0070372
IMP
Genome Projectregulation of ERK1 and ERK2 cascade
GO:0070848
IMP
Genome Projectresponse to growth factor
GO:0090004
IMP
Genome Projectpositive regulation of establishment of protein localization to plasma membrane
GO:0090630
IMP
Genome Projectactivation of GTPase activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
IDA
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0005003
IEA
Genome Projectephrin receptor activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0005515
IPI
Genome Projectprotein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005887
IDA
IEA
Genome Projectintegral component of plasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0005622
IDA
Genome Projectintracellular
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005925
IDA
IEA
Genome Projectfocal adhesion
GO:0009986
IDA
Genome Projectcell surface
GO:0030054
IEA
Genome Projectcell junction
GO:0031256
IDA
Genome Projectleading edge membrane
GO:0031258
IEA
Genome Projectlamellipodium membrane
GO:0032587
IEA
Genome Projectruffle membrane
GO:0042995
IEA
Genome Projectcell projection

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR001090Ephrin receptor ligand binding domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001426Tyrosine-protein kinase, receptor class V, conserved site
IPR001660Sterile alpha motif domain
IPR003961Fibronectin type III
IPR008266Tyrosine-protein kinase, active site
IPR008979Galactose-binding domain-like
IPR009030Growth factor receptor cysteine-rich domain
IPR011009Protein kinase-like domain
IPR013761Sterile alpha motif/pointed domain
IPR013783Immunoglobulin-like fold
IPR016257Ephrin receptor type-A /type-B
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain
IPR027936Ephrin receptor, transmembrane domain

No MapMan annotations defined for this gene.