Gene: ENSG00000142168 (Homo sapiens)

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Gene Identifier
ENSG00000142168
Transcript Identifier
ENST00000270142
Gene Type
Coding gene
Location
21 : 31659770-31668578 : positive

Family Information

Homologous gene family
HOM03P001059
(60 genes in 26 species)
specific family
Orthologous gene family
ORTHO03P004453
(19 genes in 16 species)
specific family

Descriptions

gene_descr
superoxide dismutase 1, soluble

Identifiers

Type Value
pidENSP00000270142
HGNC11179
UniprotP00441
UniprotV9HWC9

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
ISS
IEA
Genome Projectactivation of MAPK activity
GO:0000302
TAS, IEA
Genome Projectresponse to reactive oxygen species
GO:0000303
IDA
Genome Projectresponse to superoxide
GO:0001541
ISS
IEA
Genome Projectovarian follicle development
GO:0001819
IDA
Genome Projectpositive regulation of cytokine production
GO:0001890
NAS
Genome Projectplacenta development
GO:0001895
ISS
IEA
Genome Projectretina homeostasis
GO:0001975
IEA
Genome Projectresponse to amphetamine
GO:0002262
ISS
IEA
Genome Projectmyeloid cell homeostasis
GO:0002576
TAS
Genome Projectplatelet degranulation
GO:0006749
ISS
IEA
Genome Projectglutathione metabolic process
GO:0006801
IDA
ISS
IEA
Genome Projectsuperoxide metabolic process
GO:0006879
ISS
IEA
Genome Projectcellular iron ion homeostasis
GO:0006979
IEA
Genome Projectresponse to oxidative stress
GO:0007283
ISS
IEA
Genome Projectspermatogenesis
GO:0007566
ISS
NAS, IEA
Genome Projectembryo implantation
GO:0007568
IEA
Genome Projectaging
GO:0007569
IMP
Genome Projectcell aging
GO:0007596
TAS
Genome Projectblood coagulation
GO:0007605
ISS
IEA
Genome Projectsensory perception of sound
GO:0007626
ISS
IEA
Genome Projectlocomotory behavior
GO:0008089
ISS
IEA
Genome Projectanterograde axon cargo transport
GO:0008090
ISS
IEA
Genome Projectretrograde axon cargo transport
GO:0008217
ISS
IEA
Genome Projectregulation of blood pressure
GO:0009408
ISS
IEA
Genome Projectresponse to heat
GO:0010033
IDA
Genome Projectresponse to organic substance
GO:0019226
ISS
IEA
Genome Projecttransmission of nerve impulse
GO:0019430
ISS, IBA
IC, IEA
Genome Projectremoval of superoxide radicals
GO:0030168
TAS
Genome Projectplatelet activation
GO:0031667
IEA
Genome Projectresponse to nutrient levels
GO:0032287
ISS
IEA
Genome Projectperipheral nervous system myelin maintenance
GO:0032930
IDA
Genome Projectpositive regulation of superoxide anion generation
GO:0033081
NAS
Genome Projectregulation of T cell differentiation in thymus
GO:0034465
IEA
Genome Projectresponse to carbon monoxide
GO:0034599
IEA
Genome Projectcellular response to oxidative stress
GO:0035865
IEA
Genome Projectcellular response to potassium ion
GO:0040014
ISS
IEA
Genome Projectregulation of multicellular organism growth
GO:0042493
ISS
IEA
Genome Projectresponse to drug
GO:0042542
ISS
IEA
Genome Projectresponse to hydrogen peroxide
GO:0042554
IEA
Genome Projectsuperoxide anion generation
GO:0043065
IC
Genome Projectpositive regulation of apoptotic process
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043085
IDA
Genome Projectpositive regulation of catalytic activity
GO:0043087
IDA
Genome Projectregulation of GTPase activity
GO:0043524
ISS
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0045471
ISS
IEA
Genome Projectresponse to ethanol
GO:0045541
IDA
Genome Projectnegative regulation of cholesterol biosynthetic process
GO:0045859
IDA
Genome Projectregulation of protein kinase activity
GO:0046620
NAS
Genome Projectregulation of organ growth
GO:0046677
IEA
Genome Projectresponse to antibiotic
GO:0046688
IEA
Genome Projectresponse to copper ion
GO:0046716
ISS
IEA
Genome Projectmuscle cell cellular homeostasis
GO:0048538
NAS
Genome Projectthymus development
GO:0048678
ISS
IEA
Genome Projectresponse to axon injury
GO:0050665
IDA
ISS
Genome Projecthydrogen peroxide biosynthetic process
GO:0051881
IMP
Genome Projectregulation of mitochondrial membrane potential
GO:0055114
IEA
Genome Projectoxidation-reduction process
GO:0060047
IDA
Genome Projectheart contraction
GO:0060052
ISS
IEA
Genome Projectneurofilament cytoskeleton organization
GO:0060087
ISS
IEA
Genome Projectrelaxation of vascular smooth muscle
GO:0060088
ISS
IEA
Genome Projectauditory receptor cell stereocilium organization
GO:0071276
IEA
Genome Projectcellular response to cadmium ion
GO:0071318
IEA
Genome Projectcellular response to ATP
GO:0072593
IDA
Genome Projectreactive oxygen species metabolic process
GO:0097332
IEA
Genome Projectresponse to antipsychotic drug
GO:1902177
IMP
Genome Projectpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004784
EXP, IDA
TAS, IEA
Genome Projectsuperoxide dismutase activity
GO:0005507
IDA
Genome Projectcopper ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008270
IDA
Genome Projectzinc ion binding
GO:0016209
IEA
Genome Projectantioxidant activity
GO:0016491
IEA
Genome Projectoxidoreductase activity
GO:0019899
IEA
Genome Projectenzyme binding
GO:0030346
IDA
Genome Projectprotein phosphatase 2B binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042803
NAS
Genome Projectprotein homodimerization activity
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0048365
IDA
Genome ProjectRac GTPase binding
GO:0051087
IPI
Genome Projectchaperone binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005615
IDA
Genome Projectextracellular space
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005758
TAS, IEA
Genome Projectmitochondrial intermembrane space
GO:0005759
NAS
Genome Projectmitochondrial matrix
GO:0005764
IEA
Genome Projectlysosome
GO:0005777
IDA
ISS
IEA
Genome Projectperoxisome
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0030141
IEA
Genome Projectsecretory granule
GO:0031012
IDA
Genome Projectextracellular matrix
GO:0031045
IEA
Genome Projectdense core granule
GO:0031410
IDA
Genome Projectcytoplasmic vesicle
GO:0032839
IDA
Genome Projectdendrite cytoplasm
GO:0043005
IEA
Genome Projectneuron projection
GO:0043025
IDA
Genome Projectneuronal cell body
GO:0043209
IEA
Genome Projectmyelin sheath
GO:0043234
IDA
Genome Projectprotein complex
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0005886
IDA
Genome Projectplasma membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001424Superoxide dismutase, copper/zinc binding domain
IPR018152Superoxide dismutase, copper/zinc, binding site
IPR024134Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone

No MapMan annotations defined for this gene.