Gene: ENSG00000141510 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000141510
Transcript Identifier
ENST00000445888
Gene Type
Coding gene
Location
17 : 7669609-7676594 : negative

Family Information

Homologous gene family
HOM03P014610
(6 genes in 3 species)
specific family

Descriptions

gene_descr
tumor protein p53

Identifiers

Type Value
pidENSP00000391478
HGNC11998
UniprotP04637
UniprotK7PPA8

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000060
IEA
Genome Projectprotein import into nucleus, translocation
GO:0001701
IEA
Genome Projectin utero embryonic development
GO:0001756
IEA
Genome Projectsomitogenesis
GO:0001836
IEA
Genome Projectrelease of cytochrome c from mitochondria
GO:0002309
IEA
Genome ProjectT cell proliferation involved in immune response
GO:0002326
IEA
Genome ProjectB cell lineage commitment
GO:0002360
IEA
Genome ProjectT cell lineage commitment
GO:0002931
IEA
Genome Projectresponse to ischemia
GO:0006302
IEA
Genome Projectdouble-strand break repair
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IDA
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006357
IEA
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0006366
IEA
Genome Projecttranscription from RNA polymerase II promoter
GO:0006915
TAS, IEA
Genome Projectapoptotic process
GO:0006977
TAS, IEA
Genome ProjectDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006979
IEA
Genome Projectresponse to oxidative stress
GO:0007049
IEA
Genome Projectcell cycle
GO:0007179
IEA
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007369
IEA
Genome Projectgastrulation
GO:0007406
IEA
Genome Projectnegative regulation of neuroblast proliferation
GO:0007417
IEA
Genome Projectcentral nervous system development
GO:0008156
IEA
Genome Projectnegative regulation of DNA replication
GO:0009303
IEA
Genome ProjectrRNA transcription
GO:0009411
IEA
Genome Projectresponse to UV
GO:0009651
IEA
Genome Projectresponse to salt stress
GO:0009792
IEA
Genome Projectembryo development ending in birth or egg hatching
GO:0010165
IBA
IEA
Genome Projectresponse to X-ray
GO:0010666
IEA
Genome Projectpositive regulation of cardiac muscle cell apoptotic process
GO:0021549
IEA
Genome Projectcerebellum development
GO:0030512
IEA
Genome Projectnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0031065
IBA
IEA
Genome Projectpositive regulation of histone deacetylation
GO:0033077
IEA
Genome ProjectT cell differentiation in thymus
GO:0034103
IEA
Genome Projectregulation of tissue remodeling
GO:0034644
IBA
IEA
Genome Projectcellular response to UV
GO:0035264
IEA
Genome Projectmulticellular organism growth
GO:0035794
IEA
Genome Projectpositive regulation of mitochondrial membrane permeability
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0042493
IEA
Genome Projectresponse to drug
GO:0043504
IEA
Genome Projectmitochondrial DNA repair
GO:0043523
IEA
Genome Projectregulation of neuron apoptotic process
GO:0043525
IBA
IEA
Genome Projectpositive regulation of neuron apoptotic process
GO:0045861
IEA
Genome Projectnegative regulation of proteolysis
GO:0045930
IEA
Genome Projectnegative regulation of mitotic cell cycle
GO:0048568
IEA
Genome Projectembryonic organ development
GO:0051262
TAS, IEA
Genome Projectprotein tetramerization
GO:0051276
IEA
Genome Projectchromosome organization
GO:0051402
IEA
Genome Projectneuron apoptotic process
GO:0051726
IEA
Genome Projectregulation of cell cycle
GO:0061419
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070243
IEA
Genome Projectregulation of thymocyte apoptotic process
GO:0070245
ISS
IEA
Genome Projectpositive regulation of thymocyte apoptotic process
GO:0070266
IEA
Genome Projectnecroptotic process
GO:0071494
IEA
Genome Projectcellular response to UV-C
GO:0071850
IEA
Genome Projectmitotic cell cycle arrest
GO:0072363
IEA
Genome Projectregulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
GO:1901525
IEA
Genome Projectnegative regulation of macromitophagy
GO:1902108
IEA
Genome Projectregulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902253
IEA
Genome Projectregulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1904024
IEA
Genome Projectnegative regulation of glucose catabolic process to lactate via pyruvate
GO:1990144
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to hypoxia
GO:2000269
IEA
Genome Projectregulation of fibroblast apoptotic process
GO:2000378
IEA
Genome Projectnegative regulation of reactive oxygen species metabolic process
GO:2000772
IEA
Genome Projectregulation of cellular senescence
GO:0000122
IDA
ISS
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000733
IDA
Genome ProjectDNA strand renaturation
GO:0006284
TAS
Genome Projectbase-excision repair
GO:0006289
IMP
Genome Projectnucleotide-excision repair
GO:0006367
TAS
Genome Projecttranscription initiation from RNA polymerase II promoter
GO:0006461
IDA
Genome Projectprotein complex assembly
GO:0006974
IDA
Genome Projectcellular response to DNA damage stimulus
GO:0006978
IMP
Genome ProjectDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006983
IDA
Genome ProjectER overload response
GO:0007050
IDA, IMP
Genome Projectcell cycle arrest
GO:0007219
TAS
Genome ProjectNotch signaling pathway
GO:0007265
IEP
Genome ProjectRas protein signal transduction
GO:0007275
IMP
Genome Projectmulticellular organismal development
GO:0007569
IMP
Genome Projectcell aging
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008104
IDA
Genome Projectprotein localization
GO:0008283
TAS
Genome Projectcell proliferation
GO:0008285
IDA, IMP
ISS
Genome Projectnegative regulation of cell proliferation
GO:0008340
ISS
Genome Projectdetermination of adult lifespan
GO:0010332
IMP
Genome Projectresponse to gamma radiation
GO:0010467
TAS
Genome Projectgene expression
GO:0010628
IDA
Genome Projectpositive regulation of gene expression
GO:0012501
TAS, IEA
Genome Projectprogrammed cell death
GO:0016032
IMP
IEA
Genome Projectviral process
GO:0030154
TAS
Genome Projectcell differentiation
GO:0030308
IMP
Genome Projectnegative regulation of cell growth
GO:0030330
IDA, IMP
Genome ProjectDNA damage response, signal transduction by p53 class mediator
GO:0031497
IDA
Genome Projectchromatin assembly
GO:0031571
IMP
Genome Projectmitotic G1 DNA damage checkpoint
GO:0032461
IDA
Genome Projectpositive regulation of protein oligomerization
GO:0034613
IDA
Genome Projectcellular protein localization
GO:0035690
IEP
Genome Projectcellular response to drug
GO:0042149
IDA
Genome Projectcellular response to glucose starvation
GO:0042771
IDA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042981
IDA
Genome Projectregulation of apoptotic process
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0043066
IDA, IMP
Genome Projectnegative regulation of apoptotic process
GO:0043153
ISS
Genome Projectentrainment of circadian clock by photoperiod
GO:0045892
IDA
ISS
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA, IMP
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IMP, IGI
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046677
IEP
Genome Projectresponse to antibiotic
GO:0046902
TAS
Genome Projectregulation of mitochondrial membrane permeability
GO:0048147
IMP
Genome Projectnegative regulation of fibroblast proliferation
GO:0048511
IEA
Genome Projectrhythmic process
GO:0048512
ISS
Genome Projectcircadian behavior
GO:0050731
ISS
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0051097
TAS
Genome Projectnegative regulation of helicase activity
GO:0071158
IMP
Genome Projectpositive regulation of cell cycle arrest
GO:0071456
IEP
Genome Projectcellular response to hypoxia
GO:0071479
IMP
Genome Projectcellular response to ionizing radiation
GO:0072332
IMP
Genome Projectintrinsic apoptotic signaling pathway by p53 class mediator
GO:0090200
IDA
Genome Projectpositive regulation of release of cytochrome c from mitochondria
GO:0090399
IMP
Genome Projectreplicative senescence
GO:0090403
IMP
Genome Projectoxidative stress-induced premature senescence
GO:0097193
TAS
Genome Projectintrinsic apoptotic signaling pathway
GO:0097252
IDA
Genome Projectoligodendrocyte apoptotic process
GO:1900119
IMP
Genome Projectpositive regulation of execution phase of apoptosis
GO:1900740
TAS
Genome Projectpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1990440
ISS
Genome Projectpositive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:2000379
IMP
Genome Projectpositive regulation of reactive oxygen species metabolic process
GO:2001244
IMP
Genome Projectpositive regulation of intrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000977
IEA
Genome ProjectRNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979
IEA
Genome ProjectRNA polymerase II core promoter sequence-specific DNA binding
GO:0001077
IEA
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677
IMP
IEA
Genome ProjectDNA binding
GO:0003700
IDA
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0035033
IEA
Genome Projecthistone deacetylase regulator activity
GO:0044212
IDA
IEA
Genome Projecttranscription regulatory region DNA binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0000981
IDA
Genome ProjectRNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001046
ISS
Genome Projectcore promoter sequence-specific DNA binding
GO:0001085
IPI
Genome ProjectRNA polymerase II transcription factor binding
GO:0001228
IDA
Genome Projecttranscriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0002020
IPI
Genome Projectprotease binding
GO:0002039
IBA
Genome Projectp53 binding
GO:0003682
IDA
Genome Projectchromatin binding
GO:0003684
IBA
Genome Projectdamaged DNA binding
GO:0003690
IBA
Genome Projectdouble-stranded DNA binding
GO:0005507
IDA
Genome Projectcopper ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IDA
Genome ProjectATP binding
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0008270
TAS
Genome Projectzinc ion binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0019903
IPI
Genome Projectprotein phosphatase binding
GO:0030971
IPI
Genome Projectreceptor tyrosine kinase binding
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0035035
IPI
Genome Projecthistone acetyltransferase binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0043565
IBA
Genome Projectsequence-specific DNA binding
GO:0043621
IPI
Genome Projectprotein self-association
GO:0046982
IPI
Genome Projectprotein heterodimerization activity
GO:0047485
IPI
Genome Projectprotein N-terminus binding
GO:0051087
IPI
Genome Projectchaperone binding
GO:0051721
IPI
Genome Projectprotein phosphatase 2A binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005657
IBA
IEA
Genome Projectreplication fork
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005759
IEA
Genome Projectmitochondrial matrix
GO:0000790
IDA
Genome Projectnuclear chromatin
GO:0005730
IDA
Genome Projectnucleolus
GO:0005739
IDA
IEA
Genome Projectmitochondrion
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005829
IDA
Genome Projectcytosol
GO:0016363
IDA
Genome Projectnuclear matrix
GO:0016605
IDA
IEA
Genome ProjectPML body
GO:0043234
IDA
Genome Projectprotein complex
GO:0005669
IDA
Genome Projecttranscription factor TFIID complex
GO:0016604
IDA
Genome Projectnuclear body

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR002117p53 tumour suppressor family
IPR008967p53-like transcription factor, DNA-binding
IPR010991p53, tetramerisation domain
IPR011615p53, DNA-binding domain
IPR012346p53/RUNT-type transcription factor, DNA-binding domain
IPR013872p53 transactivation domain

No MapMan annotations defined for this gene.