Gene: ENSG00000140464 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000140464
Transcript Identifier
ENST00000268058
Gene Type
Coding gene
Location
15 : 73994813-74045008 : positive

Family Information

Homologous gene family
HOM03P034492
(2 genes in 2 species)
specific family

Descriptions

gene_descr
promyelocytic leukemia

Identifiers

Type Value
pidENSP00000268058
HGNC9113
UniprotP29590

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001666
IDA
Genome Projectresponse to hypoxia
GO:0001932
ISS
IEA
Genome Projectregulation of protein phosphorylation
GO:0002230
IMP
Genome Projectpositive regulation of defense response to virus by host
GO:0002376
IEA
Genome Projectimmune system process
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IMP
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006461
IDA
Genome Projectprotein complex assembly
GO:0006605
IDA, IMP
Genome Projectprotein targeting
GO:0006915
IDA
IEA
Genome Projectapoptotic process
GO:0006919
IEA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977
ISS
IEA
Genome ProjectDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050
IDA
Genome Projectcell cycle arrest
GO:0007179
IEA
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007182
IEA
Genome Projectcommon-partner SMAD protein phosphorylation
GO:0007184
IEA
Genome ProjectSMAD protein import into nucleus
GO:0007569
IEA
Genome Projectcell aging
GO:0008285
IMP
Genome Projectnegative regulation of cell proliferation
GO:0008630
IDA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009411
IEA
Genome Projectresponse to UV
GO:0010332
IEA
Genome Projectresponse to gamma radiation
GO:0010522
ISS
IEA
Genome Projectregulation of calcium ion transport into cytosol
GO:0010761
IEA
Genome Projectfibroblast migration
GO:0016032
IEA
Genome Projectviral process
GO:0016525
IMP
Genome Projectnegative regulation of angiogenesis
GO:0016925
TAS
Genome Projectprotein sumoylation
GO:0019221
TAS
Genome Projectcytokine-mediated signaling pathway
GO:0030099
IEA
Genome Projectmyeloid cell differentiation
GO:0030155
IEA
Genome Projectregulation of cell adhesion
GO:0030308
IDA
Genome Projectnegative regulation of cell growth
GO:0030578
IDA, IMP
Genome ProjectPML body organization
GO:0031065
IDA
Genome Projectpositive regulation of histone deacetylation
GO:0032211
IMP
Genome Projectnegative regulation of telomere maintenance via telomerase
GO:0032469
ISS
IEA
Genome Projectendoplasmic reticulum calcium ion homeostasis
GO:0032922
ISS
IEA
Genome Projectcircadian regulation of gene expression
GO:0032938
IDA
Genome Projectnegative regulation of translation in response to oxidative stress
GO:0034097
IDA
Genome Projectresponse to cytokine
GO:0042752
ISS
IEA
Genome Projectregulation of circadian rhythm
GO:0042771
ISS
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043153
ISS
IEA
Genome Projectentrainment of circadian clock by photoperiod
GO:0043161
IDA
Genome Projectproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043687
TAS
Genome Projectpost-translational protein modification
GO:0044267
TAS
Genome Projectcellular protein metabolic process
GO:0045087
IDA
IEA
Genome Projectinnate immune response
GO:0045165
IEA
Genome Projectcell fate commitment
GO:0045343
IEA
Genome Projectregulation of MHC class I biosynthetic process
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045930
IDA
Genome Projectnegative regulation of mitotic cell cycle
GO:0048146
IEA
Genome Projectpositive regulation of fibroblast proliferation
GO:0048384
IEA
Genome Projectretinoic acid receptor signaling pathway
GO:0048511
IEA
Genome Projectrhythmic process
GO:0050711
IEA
Genome Projectnegative regulation of interleukin-1 secretion
GO:0050713
IEA
Genome Projectnegative regulation of interleukin-1 beta secretion
GO:0050821
IDA
Genome Projectprotein stabilization
GO:0051457
IDA
Genome Projectmaintenance of protein location in nucleus
GO:0051607
IEA
Genome Projectdefense response to virus
GO:0051974
IMP
Genome Projectnegative regulation of telomerase activity
GO:0060058
IDA
Genome Projectpositive regulation of apoptotic process involved in mammary gland involution
GO:0060333
TAS
Genome Projectinterferon-gamma-mediated signaling pathway
GO:0060444
IEA
Genome Projectbranching involved in mammary gland duct morphogenesis
GO:0070059
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071353
IEA
Genome Projectcellular response to interleukin-4
GO:0072332
IEA
Genome Projectintrinsic apoptotic signaling pathway by p53 class mediator
GO:0090398
IDA
Genome Projectcellular senescence
GO:0097191
IEA
Genome Projectextrinsic apoptotic signaling pathway
GO:1902187
IDA
Genome Projectnegative regulation of viral release from host cell
GO:2000059
IMP
Genome Projectnegative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000779
IMP
Genome Projectregulation of double-strand break repair
GO:2001235
IEA
Genome Projectpositive regulation of apoptotic signaling pathway
GO:2001238
IMP
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003713
IDA
Genome Projecttranscription coactivator activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008270
IDA
IEA
Genome Projectzinc ion binding
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0032183
IPI
Genome ProjectSUMO binding
GO:0042803
IPI
Genome Projectprotein homodimerization activity
GO:0046332
IEA
Genome ProjectSMAD binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0046982
IDA
Genome Projectprotein heterodimerization activity
GO:0050897
IDA
Genome Projectcobalt ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
IEA
Genome Projectintracellular
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
IDA
TAS, IEA
Genome Projectnucleoplasm
GO:0005730
IDA
IEA
Genome Projectnucleolus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005768
IEA
Genome Projectendosome
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005789
IEA
Genome Projectendoplasmic reticulum membrane
GO:0005829
ISS
TAS, IEA
Genome Projectcytosol
GO:0016020
IEA
Genome Projectmembrane
GO:0016363
IDA
Genome Projectnuclear matrix
GO:0016605
IDA
TAS, IEA
Genome ProjectPML body
GO:0031901
IEA
Genome Projectearly endosome membrane
GO:0031965
IDA
Genome Projectnuclear membrane
GO:0042406
ISS
IEA
Genome Projectextrinsic component of endoplasmic reticulum membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000315B-box-type zinc finger
IPR001841Zinc finger, RING-type
IPR013083Zinc finger, RING/FYVE/PHD-type
IPR017907Zinc finger, RING-type, conserved site
IPR021978Protein of unknown function DUF3583

No MapMan annotations defined for this gene.