Gene: ENSG00000139687 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000139687
Transcript Identifier
ENST00000267163
Gene Type
Coding gene
Location
13 : 48303913-48480071 : positive

Family Information

Homologous gene family
HOM03P002379
(38 genes in 27 species)
specific family
Orthologous gene family
ORTHO03P004461
(19 genes in 17 species)
specific family

Descriptions

gene_descr
retinoblastoma 1

Identifiers

Type Value
pidENSP00000267163
HGNC9884
UniprotP06400
UniprotA0A024RDV3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000082
TAS, IEA
Genome ProjectG1/S transition of mitotic cell cycle
GO:0000122
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0006357
IEA
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0007050
TAS, IEA
Genome Projectcell cycle arrest
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0030182
IEA
Genome Projectneuron differentiation
GO:0031175
IEA
Genome Projectneuron projection development
GO:0034349
IEA
Genome Projectglial cell apoptotic process
GO:0035914
IEA
Genome Projectskeletal muscle cell differentiation
GO:0042551
IEA
Genome Projectneuron maturation
GO:0043353
IEA
Genome Projectenucleate erythrocyte differentiation
GO:0045651
IEA
Genome Projectpositive regulation of macrophage differentiation
GO:0045786
IEA
Genome Projectnegative regulation of cell cycle
GO:0045879
IEA
Genome Projectnegative regulation of smoothened signaling pathway
GO:0045930
IEA
Genome Projectnegative regulation of mitotic cell cycle
GO:0045944
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048565
IEA
Genome Projectdigestive tract development
GO:0048667
IEA
Genome Projectcell morphogenesis involved in neuron differentiation
GO:0050680
IEA
Genome Projectnegative regulation of epithelial cell proliferation
GO:0051146
IEA
Genome Projectstriated muscle cell differentiation
GO:0051301
IEA
Genome Projectcell division
GO:0051402
IEA
Genome Projectneuron apoptotic process
GO:0051726
IEA
Genome Projectregulation of cell cycle
GO:0071466
IEA
Genome Projectcellular response to xenobiotic stimulus
GO:0071930
IEA
Genome Projectnegative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0097284
IEA
Genome Projecthepatocyte apoptotic process
GO:2000134
TAS, IEA
Genome Projectnegative regulation of G1/S transition of mitotic cell cycle
GO:0000075
TAS
Genome Projectcell cycle checkpoint
GO:0000083
TAS
Genome Projectregulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278
TAS
Genome Projectmitotic cell cycle
GO:0006338
TAS
Genome Projectchromatin remodeling
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006469
IPI
Genome Projectnegative regulation of protein kinase activity
GO:0007049
IEA
Genome Projectcell cycle
GO:0007070
TAS
Genome Projectnegative regulation of transcription from RNA polymerase II promoter during mitosis
GO:0007093
TAS
Genome Projectmitotic cell cycle checkpoint
GO:0007265
IEP
Genome ProjectRas protein signal transduction
GO:0007346
IMP
Genome Projectregulation of mitotic cell cycle
GO:0016032
IEA
Genome Projectviral process
GO:0016568
IEA
Genome Projectchromatin modification
GO:0030521
NAS
Genome Projectandrogen receptor signaling pathway
GO:0031134
IMP
Genome Projectsister chromatid biorientation
GO:0034088
IMP
Genome Projectmaintenance of mitotic sister chromatid cohesion
GO:0043433
TAS
Genome Projectnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0043550
IDA
Genome Projectregulation of lipid kinase activity
GO:0045445
IMP
Genome Projectmyoblast differentiation
GO:0045842
IMP
Genome Projectpositive regulation of mitotic metaphase/anaphase transition
GO:0045892
IDA
TAS
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
NAS
Genome Projectpositive regulation of transcription, DNA-templated
GO:0071459
IMP
Genome Projectprotein localization to chromosome, centromeric region
GO:0071922
IMP
Genome Projectregulation of cohesin localization to chromatin
GO:0090230
TAS
Genome Projectregulation of centromere complex assembly

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001102
IEA
Genome ProjectRNA polymerase II activating transcription factor binding
GO:0019899
IEA
Genome Projectenzyme binding
GO:0001047
IDA
Genome Projectcore promoter binding
GO:0003677
TAS, IEA
Genome ProjectDNA binding
GO:0003700
TAS
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0003713
NAS
Genome Projecttranscription coactivator activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0019900
IDA
Genome Projectkinase binding
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0050681
NAS
Genome Projectandrogen receptor binding
GO:0051219
IPI
Genome Projectphosphoprotein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005667
IEA
Genome Projecttranscription factor complex
GO:0005819
IEA
Genome Projectspindle
GO:0035189
TAS, IEA
Genome ProjectRb-E2F complex
GO:0000785
TAS
Genome Projectchromatin
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0016514
TAS
Genome ProjectSWI/SNF complex
GO:0016605
IDA
Genome ProjectPML body

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR002719Retinoblastoma-associated protein, B-box
IPR002720Retinoblastoma-associated protein, A-box
IPR013763Cyclin-like
IPR015030Retinoblastoma-associated protein, C-terminal
IPR024599Retinoblastoma-associated protein, N-terminal
IPR028309Retinoblastoma protein family

No MapMan annotations defined for this gene.