Gene: ENSG00000139625 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000139625
Transcript Identifier
ENST00000547035
Gene Type
Coding gene
Location
12 : 53481182-53487391 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P022552
(4 genes in 3 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
mitogen-activated protein kinase kinase kinase 12

Identifiers

Type Value
pidENSP00000448689
HGNC6851
UniprotQ12852

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000186
IEA
Genome Projectactivation of MAPKK activity
GO:0006468
IDA
ISS
IEA
Genome Projectprotein phosphorylation
GO:0007254
ISS
TAS, IEA
Genome ProjectJNK cascade
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016572
ISS
IEA
Genome Projecthistone phosphorylation
GO:0018105
ISS
IEA
Genome Projectpeptidyl-serine phosphorylation
GO:0018107
ISS
IEA
Genome Projectpeptidyl-threonine phosphorylation
GO:0035556
TAS
Genome Projectintracellular signal transduction
GO:0046777
ISS
IEA
Genome Projectprotein autophosphorylation
GO:0098779
IGI
Genome Projectmitophagy in response to mitochondrial depolarization

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
TAS, IEA
Genome Projectprotein kinase activity
GO:0004674
ISS
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004709
IEA
Genome ProjectMAP kinase kinase kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0042803
ISS
IEA
Genome Projectprotein homodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
TAS, IEA
Genome Projectcytoplasm
GO:0005829
ISS
IEA
Genome Projectcytosol
GO:0005886
ISS
TAS, IEA
Genome Projectplasma membrane
GO:0016020
ISS
IEA
Genome Projectmembrane
GO:0030424
IEA
Genome Projectaxon
GO:0030426
IEA
Genome Projectgrowth cone

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017419Mitogen-activated protein kinase kinase kinase 12/13
IPR027257Mitogen-activated protein kinase kinase kinase 12

No MapMan annotations defined for this gene.