Gene: ENSG00000139318 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000139318
Transcript Identifier
ENST00000279488
Gene Type
Coding gene
Location
12 : 89349254-89352039 : negative

Family Information

Homologous gene family
HOM03P000093
(285 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P034441
(3 genes in 2 species)
specific family

Descriptions

gene_descr
dual specificity phosphatase 6

Identifiers

Type Value
pidENSP00000279488
HGNC3072
UniprotQ16828
UniprotA0A024RBC1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000188
IDA
IEA
Genome Projectinactivation of MAPK activity
GO:0001933
IEA
Genome Projectnegative regulation of protein phosphorylation
GO:0006470
IEA
Genome Projectprotein dephosphorylation
GO:0010033
IEA
Genome Projectresponse to organic substance
GO:0010942
IEA
Genome Projectpositive regulation of cell death
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0016311
IEA
Genome Projectdephosphorylation
GO:0030154
IEA
Genome Projectcell differentiation
GO:0035335
IDA
IEA
Genome Projectpeptidyl-tyrosine dephosphorylation
GO:0042493
IEA
Genome Projectresponse to drug
GO:0060420
IBA
IEA
Genome Projectregulation of heart growth
GO:0070373
IMP
IEA
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0070848
IEA
Genome Projectresponse to growth factor
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0009953
IBA
Genome Projectdorsal/ventral pattern formation
GO:0034134
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0040036
IBA
Genome Projectregulation of fibroblast growth factor receptor signaling pathway
GO:0042663
IBA
Genome Projectregulation of endodermal cell fate specification
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0051403
TAS
Genome Projectstress-activated MAPK cascade
GO:0051409
IEP
Genome Projectresponse to nitrosative stress

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004721
IEA
Genome Projectphosphoprotein phosphatase activity
GO:0004725
IEA
Genome Projectprotein tyrosine phosphatase activity
GO:0008138
IEA
Genome Projectprotein tyrosine/serine/threonine phosphatase activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0016791
IEA
Genome Projectphosphatase activity
GO:0017017
IDA
IEA
Genome ProjectMAP kinase tyrosine/serine/threonine phosphatase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
IEA
Genome Projectcytosol
GO:0005654
TAS
Genome Projectnucleoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000340Dual specificity phosphatase, catalytic domain
IPR000387Tyrosine specific protein phosphatases domain
IPR001763Rhodanese-like domain
IPR008343Mitogen-activated protein (MAP) kinase phosphatase
IPR020422Dual specificity protein phosphatase domain
IPR024950Dual specificity phosphatase
IPR029021Protein-tyrosine phosphatase-like

No MapMan annotations defined for this gene.