Gene: ENSG00000138696 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000138696
Transcript Identifier
ENST00000440890
Gene Type
Coding gene
Location
4 : 95051700-95154673 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P015166
(6 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
bone morphogenetic protein receptor, type IB

Identifiers

Type Value
pidENSP00000401907
HGNC1077
UniprotO00238

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001501
IMP
Genome Projectskeletal system development
GO:0001502
NAS, IEA
Genome Projectcartilage condensation
GO:0001550
ISS
IEA
Genome Projectovarian cumulus expansion
GO:0001654
ISS
IEA
Genome Projecteye development
GO:0002062
IEA
Genome Projectchondrocyte differentiation
GO:0002063
ISS
Genome Projectchondrocyte development
GO:0006468
IDA
IEA
Genome Projectprotein phosphorylation
GO:0006954
IEA
Genome Projectinflammatory response
GO:0007178
IEA
Genome Projecttransmembrane receptor protein serine/threonine kinase signaling pathway
GO:0009953
IEA
Genome Projectdorsal/ventral pattern formation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0023014
IEA
Genome Projectsignal transduction by protein phosphorylation
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030166
ISS
Genome Projectproteoglycan biosynthetic process
GO:0030501
IMP
Genome Projectpositive regulation of bone mineralization
GO:0030509
IDA
TAS, NAS
Genome ProjectBMP signaling pathway
GO:0031290
IEA
Genome Projectretinal ganglion cell axon guidance
GO:0035108
IMP
Genome Projectlimb morphogenesis
GO:0042698
ISS
IEA
Genome Projectovulation cycle
GO:0043010
IEA
Genome Projectcamera-type eye development
GO:0045597
IMP
Genome Projectpositive regulation of cell differentiation
GO:0045669
IMP
Genome Projectpositive regulation of osteoblast differentiation
GO:0045944
IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0051216
IEA
Genome Projectcartilage development
GO:0060041
IEA
Genome Projectretina development in camera-type eye
GO:0060350
ISS
Genome Projectendochondral bone morphogenesis
GO:0061036
ISS
Genome Projectpositive regulation of cartilage development
GO:0071773
IMP
Genome Projectcellular response to BMP stimulus
GO:1902043
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902731
ISS
Genome Projectnegative regulation of chondrocyte proliferation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0001948
IPI
Genome Projectglycoprotein binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
IDA
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004675
IMP
NAS, IEA
Genome Projecttransmembrane receptor protein serine/threonine kinase activity
GO:0004702
IEA
Genome Projectreceptor signaling protein serine/threonine kinase activity
GO:0005025
IEA
Genome Projecttransforming growth factor beta receptor activity, type I
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IDA
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0046332
IDA
Genome ProjectSMAD binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
TAS
Genome Projectplasma membrane
GO:0005887
IC
Genome Projectintegral component of plasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030425
IEA
Genome Projectdendrite
GO:0043025
IEA
Genome Projectneuronal cell body
GO:0043235
TAS
Genome Projectreceptor complex
GO:1990712
IC
Genome ProjectHFE-transferrin receptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000333Ser/Thr protein kinase, TGFB receptor
IPR000472Activin types I and II receptor domain
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR003605GS domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.