Gene: ENSG00000138448 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000138448
Transcript Identifier
ENST00000261023
Gene Type
Coding gene
Location
2 : 186590339-186677292 : positive

Family Information

Homologous gene family
HOM03P002672
(35 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P009315
(9 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
integrin, alpha V

Identifiers

Type Value
pidENSP00000261023
HGNC6150
UniprotP06756
UniprotL7RXH0

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001568
IEA
Genome Projectblood vessel development
GO:0007155
IDA
IEA
Genome Projectcell adhesion
GO:0007229
NAS, IEA
Genome Projectintegrin-mediated signaling pathway
GO:0030335
IEA
Genome Projectpositive regulation of cell migration
GO:0033690
IEA
Genome Projectpositive regulation of osteoblast proliferation
GO:0043277
IEA
Genome Projectapoptotic cell clearance
GO:0070371
ISS
IEA
Genome ProjectERK1 and ERK2 cascade
GO:0097192
ISS
IEA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:2000425
ISS
IEA
Genome Projectregulation of apoptotic cell clearance
GO:0001525
IEP
Genome Projectangiogenesis
GO:0002474
TAS
Genome Projectantigen processing and presentation of peptide antigen via MHC class I
GO:0002479
TAS
Genome Projectantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0007160
IDA, IMP
NAS
Genome Projectcell-matrix adhesion
GO:0007411
TAS
Genome Projectaxon guidance
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008284
IDA
Genome Projectpositive regulation of cell proliferation
GO:0010745
IMP
Genome Projectnegative regulation of macrophage derived foam cell differentiation
GO:0010888
IMP
Genome Projectnegative regulation of lipid storage
GO:0016032
IEA
Genome Projectviral process
GO:0016049
IMP
Genome Projectcell growth
GO:0016477
IMP
Genome Projectcell migration
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0031589
IMP
Genome Projectcell-substrate adhesion
GO:0032369
IMP
Genome Projectnegative regulation of lipid transport
GO:0034113
IMP
Genome Projectheterotypic cell-cell adhesion
GO:0034446
IDA
Genome Projectsubstrate adhesion-dependent cell spreading
GO:0035987
IMP
Genome Projectendodermal cell differentiation
GO:0038027
IMP
Genome Projectapolipoprotein A-I-mediated signaling pathway
GO:0042590
TAS
Genome Projectantigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045715
IMP
Genome Projectnegative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045785
IDA
Genome Projectpositive regulation of cell adhesion
GO:0046718
IMP
TAS
Genome Projectviral entry into host cell
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0050748
IMP
Genome Projectnegative regulation of lipoprotein metabolic process
GO:0050764
IDA
Genome Projectregulation of phagocytosis
GO:0050900
TAS
Genome Projectleukocyte migration
GO:0050919
IMP
Genome Projectnegative chemotaxis
GO:0052066
NAS
Genome Projectentry of symbiont into host cell by promotion of host phagocytosis
GO:0070588
IDA
Genome Projectcalcium ion transmembrane transport
GO:2000536
IDA
Genome Projectnegative regulation of entry of bacterium into host cell
GO:2001237
IMP
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001846
ISS
IEA
Genome Projectopsonin binding
GO:0005080
ISS
IEA
Genome Projectprotein kinase C binding
GO:0001618
IEA
Genome Projectvirus receptor activity
GO:0001968
IDA
Genome Projectfibronectin binding
GO:0002020
IDA
Genome Projectprotease binding
GO:0005245
IDA
Genome Projectvoltage-gated calcium channel activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0050431
ISS
Genome Projecttransforming growth factor beta binding
GO:0050840
IDA
Genome Projectextracellular matrix binding
GO:1990430
IDA
Genome Projectextracellular matrix protein binding
GO:0031994
IDA
Genome Projectinsulin-like growth factor I binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
IEA
Genome Projectintracellular
GO:0008305
IDA
NAS, IEA
Genome Projectintegrin complex
GO:0009897
IEA
Genome Projectexternal side of plasma membrane
GO:0016020
ISS
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0005886
IDA
TAS
Genome Projectplasma membrane
GO:0005887
TAS, NAS
Genome Projectintegral component of plasma membrane
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0009986
IDA
ISS
Genome Projectcell surface
GO:0031258
IDA
Genome Projectlamellipodium membrane
GO:0031527
IDA
Genome Projectfilopodium membrane
GO:0031528
IDA
Genome Projectmicrovillus membrane
GO:0032587
IDA
Genome Projectruffle membrane
GO:0034683
IDA
Genome Projectintegrin alphav-beta3 complex
GO:0034684
IDA
Genome Projectintegrin alphav-beta5 complex
GO:0034686
IDA
Genome Projectintegrin alphav-beta8 complex
GO:0035867
IDA
Genome Projectalphav-beta3 integrin-IGF-1-IGF1R complex
GO:0045335
TAS
Genome Projectphagocytic vesicle
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000413Integrin alpha chain
IPR013517FG-GAP repeat
IPR013519Integrin alpha beta-propellor
IPR013649Integrin alpha-2
IPR018184Integrin alpha chain, C-terminal cytoplasmic region, conserved site

No MapMan annotations defined for this gene.