Gene: ENSG00000138435 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000138435
Transcript Identifier
ENST00000261007
Gene Type
Coding gene
Location
2 : 174748124-174764394 : negative

Family Information

Homologous gene family
HOM03P000517
(94 genes in 7 species)
specific family
Orthologous gene family
ORTHO03P068301
(2 genes in 2 species)
specific family

Descriptions

gene_descr
cholinergic receptor, nicotinic, alpha 1 (muscle)

Identifiers

Type Value
pidENSP00000261007
HGNC1955
UniprotP02708

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003009
IMP
IEA
Genome Projectskeletal muscle contraction
GO:0006810
TAS, IEA
Genome Projecttransport
GO:0006811
IEA
Genome Projection transport
GO:0006812
IEA
Genome Projectcation transport
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007268
TAS
Genome Projectsynaptic transmission
GO:0007271
IBA
Genome Projectsynaptic transmission, cholinergic
GO:0007274
IMP
Genome Projectneuromuscular synaptic transmission
GO:0007528
IMP
Genome Projectneuromuscular junction development
GO:0019228
IMP
Genome Projectneuronal action potential
GO:0034220
TAS, IEA
Genome Projection transmembrane transport
GO:0035094
IBA
Genome Projectresponse to nicotine
GO:0042391
IMP
Genome Projectregulation of membrane potential
GO:0046716
IMP
Genome Projectmuscle cell cellular homeostasis
GO:0048630
IMP
Genome Projectskeletal muscle tissue growth
GO:0050881
IMP
Genome Projectmusculoskeletal movement
GO:0050905
IMP
Genome Projectneuromuscular process
GO:0070050
IMP
Genome Projectneuron cellular homeostasis
GO:0098655
IMP
ISS
TAS, IEA
Genome Projectcation transmembrane transport

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004889
IMP
ISS
TAS, IEA
Genome Projectacetylcholine-activated cation-selective channel activity
GO:0005216
TAS, IEA
Genome Projection channel activity
GO:0005230
IEA
Genome Projectextracellular ligand-gated ion channel activity
GO:0015464
ISS
TAS, IEA
Genome Projectacetylcholine receptor activity
GO:0042166
ISS, IBA
IEA
Genome Projectacetylcholine binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
ISS
TAS, IEA
Genome Projectplasma membrane
GO:0005892
ISS
TAS, IEA
Genome Projectacetylcholine-gated channel complex
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030054
IEA
Genome Projectcell junction
GO:0031594
IDA
ISS
Genome Projectneuromuscular junction
GO:0043005
IBA
Genome Projectneuron projection
GO:0045202
IEA
Genome Projectsynapse
GO:0045211
NAS, IEA
Genome Projectpostsynaptic membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR002394Nicotinic acetylcholine receptor
IPR006029Neurotransmitter-gated ion-channel transmembrane domain
IPR006201Neurotransmitter-gated ion-channel
IPR006202Neurotransmitter-gated ion-channel ligand-binding domain
IPR018000Neurotransmitter-gated ion-channel, conserved site
IPR027361Nicotinic acetylcholine-gated receptor, transmembrane domain

No MapMan annotations defined for this gene.