Gene: ENSG00000137845 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000137845
Transcript Identifier
ENST00000260408
Gene Type
Coding gene
Location
15 : 58597547-58749534 : negative

Family Information

Homologous gene family
HOM03P008887
(9 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P040741
(3 genes in 3 species)
specific family

Descriptions

gene_descr
ADAM metallopeptidase domain 10

Identifiers

Type Value
pidENSP00000260408
HGNC188
UniprotO14672
UniprotA0A024R5U5

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001701
ISS
IEA
Genome Projectin utero embryonic development
GO:0006468
ISS
IEA
Genome Projectprotein phosphorylation
GO:0006508
IEA
Genome Projectproteolysis
GO:0006509
IDA, IMP
IEA
Genome Projectmembrane protein ectodomain proteolysis
GO:0007219
ISS
TAS, IEA
Genome ProjectNotch signaling pathway
GO:0007162
IDA
NAS
Genome Projectnegative regulation of cell adhesion
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007220
TAS
Genome ProjectNotch receptor processing
GO:0007229
NAS
Genome Projectintegrin-mediated signaling pathway
GO:0007267
NAS
Genome Projectcell-cell signaling
GO:0007411
TAS
Genome Projectaxon guidance
GO:0008284
IMP
Genome Projectpositive regulation of cell proliferation
GO:0010820
IMP
Genome Projectpositive regulation of T cell chemotaxis
GO:0022617
TAS
Genome Projectextracellular matrix disassembly
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0030307
IMP
Genome Projectpositive regulation of cell growth
GO:0030335
IMP
Genome Projectpositive regulation of cell migration
GO:0030574
TAS
Genome Projectcollagen catabolic process
GO:0034612
IDA
Genome Projectresponse to tumor necrosis factor
GO:0042117
IMP
Genome Projectmonocyte activation
GO:0048013
TAS
Genome Projectephrin receptor signaling pathway
GO:0051088
IMP
Genome ProjectPMA-inducible membrane protein ectodomain proteolysis
GO:0051089
IDA
Genome Projectconstitutive protein ectodomain proteolysis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004175
ISS
IEA
Genome Projectendopeptidase activity
GO:0004222
IMP
NAS, IEA
Genome Projectmetalloendopeptidase activity
GO:0008237
IDA, IMP
TAS, IEA
Genome Projectmetallopeptidase activity
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0019901
ISS
IEA
Genome Projectprotein kinase binding
GO:0042803
ISS
IEA
Genome Projectprotein homodimerization activity
GO:0005102
NAS
Genome Projectreceptor binding
GO:0005178
NAS
Genome Projectintegrin binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008233
IEA
Genome Projectpeptidase activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0017124
IEA
Genome ProjectSH3 domain binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
ISS
IEA
Genome Projectnucleus
GO:0005737
ISS
IEA
Genome Projectcytoplasm
GO:0014069
IEA
Genome Projectpostsynaptic density
GO:0005794
IDA
Genome ProjectGolgi apparatus
GO:0005798
IDA
Genome ProjectGolgi-associated vesicle
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0009986
IDA
Genome Projectcell surface
GO:0012505
IEA
Genome Projectendomembrane system
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0016021
NAS, IEA
Genome Projectintegral component of membrane
GO:0043231
IDA
Genome Projectintracellular membrane-bounded organelle
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0097038
IDA
Genome Projectperinuclear endoplasmic reticulum
GO:0097197
IDA
Genome Projecttetraspanin-enriched microdomain

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001590Peptidase M12B, ADAM/reprolysin
IPR001762Disintegrin domain
IPR002870Peptidase M12B, propeptide
IPR024079Metallopeptidase, catalytic domain
IPR027053Disintegrin and metalloproteinase domain-containing protein 10

No MapMan annotations defined for this gene.