Gene: ENSG00000137801 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000137801
Transcript Identifier
ENST00000260356
Gene Type
Coding gene
Location
15 : 39581858-39595369 : positive

Family Information

Homologous gene family
HOM03P008890
(9 genes in 4 species)
specific family

Descriptions

gene_descr
thrombospondin 1

Identifiers

Type Value
pidENSP00000260356
HGNC11785
UniprotP07996

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
IMP
Genome Projectactivation of MAPK activity
GO:0001666
NAS
Genome Projectresponse to hypoxia
GO:0001937
IDA, IMP
Genome Projectnegative regulation of endothelial cell proliferation
GO:0001953
IDA
Genome Projectnegative regulation of cell-matrix adhesion
GO:0002040
IMP
Genome Projectsprouting angiogenesis
GO:0002544
IEP
Genome Projectchronic inflammatory response
GO:0002576
TAS
Genome Projectplatelet degranulation
GO:0002581
IDA
Genome Projectnegative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002605
IDA
Genome Projectnegative regulation of dendritic cell antigen processing and presentation
GO:0003151
IEA
Genome Projectoutflow tract morphogenesis
GO:0003197
IEA
Genome Projectendocardial cushion development
GO:0003417
IEA
Genome Projectgrowth plate cartilage development
GO:0006493
TAS
Genome Projectprotein O-linked glycosylation
GO:0006954
IDA
IEA
Genome Projectinflammatory response
GO:0006955
IEP
Genome Projectimmune response
GO:0006986
IEA
Genome Projectresponse to unfolded protein
GO:0007050
IDA
Genome Projectcell cycle arrest
GO:0007155
NAS, IEA
Genome Projectcell adhesion
GO:0007596
TAS
Genome Projectblood coagulation
GO:0009749
IDA
Genome Projectresponse to glucose
GO:0010595
IDA
Genome Projectpositive regulation of endothelial cell migration
GO:0010596
IDA
Genome Projectnegative regulation of endothelial cell migration
GO:0010748
IDA
Genome Projectnegative regulation of plasma membrane long-chain fatty acid transport
GO:0010751
IDA
Genome Projectnegative regulation of nitric oxide mediated signal transduction
GO:0010754
IDA
Genome Projectnegative regulation of cGMP-mediated signaling
GO:0010757
IDA
Genome Projectnegative regulation of plasminogen activation
GO:0010759
ISS
Genome Projectpositive regulation of macrophage chemotaxis
GO:0010763
IDA
Genome Projectpositive regulation of fibroblast migration
GO:0010811
IEA
Genome Projectpositive regulation of cell-substrate adhesion
GO:0016477
IDA
Genome Projectcell migration
GO:0016525
IDA
IEA
Genome Projectnegative regulation of angiogenesis
GO:0018149
IDA
Genome Projectpeptide cross-linking
GO:0030168
TAS
Genome Projectplatelet activation
GO:0030194
IDA
Genome Projectpositive regulation of blood coagulation
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0030335
IDA, IMP
Genome Projectpositive regulation of cell migration
GO:0030511
IDA
Genome Projectpositive regulation of transforming growth factor beta receptor signaling pathway
GO:0030823
IDA
Genome Projectregulation of cGMP metabolic process
GO:0032026
IDA
Genome Projectresponse to magnesium ion
GO:0032570
TAS
Genome Projectresponse to progesterone
GO:0032695
IDA
Genome Projectnegative regulation of interleukin-12 production
GO:0032914
ISS
Genome Projectpositive regulation of transforming growth factor beta1 production
GO:0034605
NAS
Genome Projectcellular response to heat
GO:0034976
ISS
Genome Projectresponse to endoplasmic reticulum stress
GO:0036066
TAS
Genome Projectprotein O-linked fucosylation
GO:0040037
IDA
Genome Projectnegative regulation of fibroblast growth factor receptor signaling pathway
GO:0042327
IMP
Genome Projectpositive regulation of phosphorylation
GO:0042493
IEP
Genome Projectresponse to drug
GO:0042535
IDA
Genome Projectpositive regulation of tumor necrosis factor biosynthetic process
GO:0043032
IDA
Genome Projectpositive regulation of macrophage activation
GO:0043066
IDA
Genome Projectnegative regulation of apoptotic process
GO:0043154
IDA
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043536
IDA
Genome Projectpositive regulation of blood vessel endothelial cell migration
GO:0043537
IDA
Genome Projectnegative regulation of blood vessel endothelial cell migration
GO:0043652
IDA
Genome Projectengulfment of apoptotic cell
GO:0043687
TAS
Genome Projectpost-translational protein modification
GO:0044267
TAS
Genome Projectcellular protein metabolic process
GO:0045727
IDA
Genome Projectpositive regulation of translation
GO:0045766
IMP
Genome Projectpositive regulation of angiogenesis
GO:0048266
ISS
Genome Projectbehavioral response to pain
GO:0048514
IEA
Genome Projectblood vessel morphogenesis
GO:0050921
IDA
Genome Projectpositive regulation of chemotaxis
GO:0051592
IDA
Genome Projectresponse to calcium ion
GO:0051895
TAS
Genome Projectnegative regulation of focal adhesion assembly
GO:0051897
IDA
Genome Projectpositive regulation of protein kinase B signaling
GO:0051918
IDA
Genome Projectnegative regulation of fibrinolysis
GO:0071732
IEA
Genome Projectcellular response to nitric oxide
GO:1902043
IDA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000353
IDA
Genome Projectpositive regulation of endothelial cell apoptotic process
GO:2000379
IDA
Genome Projectpositive regulation of reactive oxygen species metabolic process
GO:2001027
IDA
Genome Projectnegative regulation of endothelial cell chemotaxis
GO:2001237
TAS
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001786
IDA
Genome Projectphosphatidylserine binding
GO:0001948
NAS
Genome Projectglycoprotein binding
GO:0001968
IDA
Genome Projectfibronectin binding
GO:0005178
IMP
Genome Projectintegrin binding
GO:0005509
NAS, IEA
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008201
IDA
IEA
Genome Projectheparin binding
GO:0017134
IDA
Genome Projectfibroblast growth factor binding
GO:0030169
IDA
Genome Projectlow-density lipoprotein particle binding
GO:0042802
NAS
Genome Projectidentical protein binding
GO:0043236
IDA
Genome Projectlaminin binding
GO:0043394
TAS
Genome Projectproteoglycan binding
GO:0050431
ISS
TAS
Genome Projecttransforming growth factor beta binding
GO:0050840
IEA
Genome Projectextracellular matrix binding
GO:0070051
IDA
Genome Projectfibrinogen binding
GO:0070052
IDA
Genome Projectcollagen V binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005577
IDA
Genome Projectfibrinogen complex
GO:0005615
IDA
IEA
Genome Projectextracellular space
GO:0005783
ISS
IEA
Genome Projectendoplasmic reticulum
GO:0005788
TAS
Genome Projectendoplasmic reticulum lumen
GO:0009897
IDA
Genome Projectexternal side of plasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0016529
ISS
IEA
Genome Projectsarcoplasmic reticulum
GO:0030141
IDA
Genome Projectsecretory granule
GO:0031012
IDA
ISS
TAS
Genome Projectextracellular matrix
GO:0031091
IDA
Genome Projectplatelet alpha granule
GO:0031093
TAS
Genome Projectplatelet alpha granule lumen
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000742EGF-like domain
IPR000884Thrombospondin type-1 (TSP1) repeat
IPR001007VWFC domain
IPR001791Laminin G domain
IPR003367Thrombospondin, type 3-like repeat
IPR008859Thrombospondin, C-terminal
IPR013032EGF-like, conserved site
IPR013320Concanavalin A-like lectin/glucanase domain
IPR017897Thrombospondin, type 3 repeat
IPR028499Thrombospondin-1
IPR028974TSP type-3 repeat

No MapMan annotations defined for this gene.