Gene: ENSG00000137764 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000137764
Transcript Identifier
ENST00000178640
Gene Type
Coding gene
Location
15 : 67543336-67806750 : positive

Family Information

Homologous gene family
HOM03P000001
(4368 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P002205
(32 genes in 25 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
mitogen-activated protein kinase kinase 5

Identifiers

Type Value
pidENSP00000178640
HGNC6845
UniprotQ13163
UniprotA0A024R5Y2

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
ISS
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000165
IEA
Genome ProjectMAPK cascade
GO:0000187
ISS, IBA
IEA
Genome Projectactivation of MAPK activity
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007507
IEA
Genome Projectheart development
GO:0016310
IEA
Genome Projectphosphorylation
GO:0030307
IEA
Genome Projectpositive regulation of cell growth
GO:0032088
ISS
IEA
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0034115
ISS
IEA
Genome Projectnegative regulation of heterotypic cell-cell adhesion
GO:0043154
ISS
IEA
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045415
ISS
IEA
Genome Projectnegative regulation of interleukin-8 biosynthetic process
GO:0045944
ISS
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0050679
IEA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0051247
ISS
IEA
Genome Projectpositive regulation of protein metabolic process
GO:0060761
ISS
IEA
Genome Projectnegative regulation of response to cytokine stimulus
GO:0070375
IEA
Genome ProjectERK5 cascade
GO:0071363
ISS
IEA
Genome Projectcellular response to growth factor stimulus
GO:0090051
ISS
IEA
Genome Projectnegative regulation of cell migration involved in sprouting angiogenesis
GO:2000342
ISS
IEA
Genome Projectnegative regulation of chemokine (C-X-C motif) ligand 2 production
GO:2001240
ISS
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0007165
TAS
Genome Projectsignal transduction
GO:0018108
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0071499
TAS
Genome Projectcellular response to laminar fluid shear stress

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
TAS, IEA
Genome Projectprotein kinase activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0004674
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004708
IBA
Genome ProjectMAP kinase kinase activity
GO:0004713
IEA
Genome Projectprotein tyrosine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0016740
IEA
Genome Projecttransferase activity
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
Genome Projectnucleus
GO:0005819
IEA
Genome Projectspindle
GO:0005829
IEA
Genome Projectcytosol
GO:0005622
IBA
Genome Projectintracellular

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000270PB1 domain
IPR000719Protein kinase domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.