Gene: ENSG00000137757 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000137757
Transcript Identifier
ENST00000526056
Gene Type
Coding gene
Location
11 : 104995744-105023136 : negative

Family Information

Homologous gene family
HOM03P003300
(30 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P067346
(2 genes in 2 species)
specific family

Descriptions

gene_descr
caspase 5, apoptosis-related cysteine peptidase

Identifiers

Type Value
pidENSP00000436877
HGNC1506
UniprotP51878

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006508
TAS, IEA
Genome Projectproteolysis
GO:0006915
TAS, IEA
Genome Projectapoptotic process
GO:0021762
IEP
Genome Projectsubstantia nigra development
GO:0035234
IEA
Genome Projectectopic germ cell programmed cell death
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0050718
IEA
Genome Projectpositive regulation of interleukin-1 beta secretion
GO:0050727
IBA
Genome Projectregulation of inflammatory response
GO:0070269
IEA
Genome Projectpyroptosis
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus
GO:0097194
IBA
Genome Projectexecution phase of apoptosis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004197
IEA
Genome Projectcysteine-type endopeptidase activity
GO:0008233
IEA
Genome Projectpeptidase activity
GO:0008234
TAS, IEA
Genome Projectcysteine-type peptidase activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0097200
IBA
Genome Projectcysteine-type endopeptidase activity involved in execution phase of apoptosis

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IBA
Genome Projectcytoplasm
GO:0072558
IDA
Genome ProjectNLRP1 inflammasome complex
GO:0072557
IBA
Genome ProjectIPAF inflammasome complex
GO:0072559
IBA
Genome ProjectNLRP3 inflammasome complex
GO:0097169
IBA
Genome ProjectAIM2 inflammasome complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001309Peptidase C14, ICE, catalytic subunit p20
IPR001315CARD domain
IPR002138Peptidase C14, caspase non-catalytic subunit p10
IPR011029Death-like domain
IPR011600Peptidase C14, caspase domain
IPR015917Peptidase C14A, caspase precursor p45, core
IPR016129Peptidase C14, ICE, catalytic subunit p20, active site
IPR017350Peptidase C14A, Casp1-type
IPR029030Caspase-like domain

No MapMan annotations defined for this gene.