Gene: ENSG00000137710 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000137710
Transcript Identifier
ENST00000405097
Gene Type
Coding gene
Location
11 : 110199612-110279692 : negative

Family Information

Homologous gene family
HOM03P007566
(11 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P010170
(8 genes in 4 species)
specific family

Descriptions

gene_descr
radixin

Identifiers

Type Value
pidENSP00000384136
HGNC9944
UniprotP35241

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0008360
IMP
Genome Projectregulation of cell shape
GO:0008361
IGI
Genome Projectregulation of cell size
GO:0010628
IGI
Genome Projectpositive regulation of gene expression
GO:0010737
ISS
Genome Projectprotein kinase A signaling
GO:0030033
IEA
Genome Projectmicrovillus assembly
GO:0030335
IMP
Genome Projectpositive regulation of cell migration
GO:0032231
IMP
Genome Projectregulation of actin filament bundle assembly
GO:0032487
ISS
Genome Projectregulation of Rap protein signal transduction
GO:0034111
IMP
Genome Projectnegative regulation of homotypic cell-cell adhesion
GO:0034260
IMP
Genome Projectnegative regulation of GTPase activity
GO:0043087
IGI
Genome Projectregulation of GTPase activity
GO:0045176
IEA
Genome Projectapical protein localization
GO:0045184
ISS
Genome Projectestablishment of protein localization
GO:0045792
IMP
Genome Projectnegative regulation of cell size
GO:0051693
IEA
Genome Projectactin filament capping
GO:0061028
IGI
Genome Projectestablishment of endothelial barrier
GO:0090002
IMP
Genome Projectestablishment of protein localization to plasma membrane
GO:0097067
ISS
Genome Projectcellular response to thyroid hormone stimulus
GO:1900027
IMP
Genome Projectregulation of ruffle assembly
GO:1900087
ISS
Genome Projectpositive regulation of G1/S transition of mitotic cell cycle
GO:1902115
IGI
Genome Projectregulation of organelle assembly
GO:1902966
IGI
Genome Projectpositive regulation of protein localization to early endosome
GO:1903364
IGI
Genome Projectpositive regulation of cellular protein catabolic process
GO:1903392
IMP
Genome Projectnegative regulation of adherens junction organization
GO:2000643
IGI
Genome Projectpositive regulation of early endosome to late endosome transport

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003779
IDA
IEA
Genome Projectactin binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008092
IEA
Genome Projectcytoskeletal protein binding
GO:0042803
ISS
Genome Projectprotein homodimerization activity
GO:0044822
IDA
Genome Projectpoly(A) RNA binding
GO:0051018
ISS
Genome Projectprotein kinase A binding
GO:0051117
IPI
Genome ProjectATPase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001726
IEA
Genome Projectruffle
GO:0005615
IDA
Genome Projectextracellular space
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005886
IDA
ISS
IEA
Genome Projectplasma membrane
GO:0005902
ISS
IEA
Genome Projectmicrovillus
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0016020
IEA
Genome Projectmembrane
GO:0016324
IDA
Genome Projectapical plasma membrane
GO:0019898
IEA
Genome Projectextrinsic component of membrane
GO:0030027
ISS
IEA
Genome Projectlamellipodium
GO:0030175
ISS
IEA
Genome Projectfilopodium
GO:0030864
ISS
Genome Projectcortical actin cytoskeleton
GO:0032154
IEA
Genome Projectcleavage furrow
GO:0032420
IEA
Genome Projectstereocilium
GO:0043209
IEA
Genome Projectmyelin sheath
GO:0045177
IEA
Genome Projectapical part of cell
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0071944
IDA
Genome Projectcell periphery

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000299FERM domain
IPR000798Ezrin/radixin/moesin-like
IPR008954Moesin tail domain
IPR011174Ezrin/radixin/moesin
IPR011259Ezrin/radixin/moesin, C-terminal
IPR011993PH domain-like
IPR014352FERM/acyl-CoA-binding protein, 3-helical bundle
IPR018979FERM, N-terminal
IPR018980FERM, C-terminal PH-like domain
IPR019747FERM conserved site
IPR019748FERM central domain
IPR019749Band 4.1 domain
IPR029071Ubiquitin-related domain

No MapMan annotations defined for this gene.