Gene: ENSG00000137462 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000137462
Transcript Identifier
ENST00000260010
Gene Type
Coding gene
Location
4 : 153702908-153705262 : positive

Family Information

Homologous gene family
HOM03P004593
(20 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P067303
(2 genes in 2 species)
specific family

Descriptions

gene_descr
toll-like receptor 2

Identifiers

Type Value
pidENSP00000260010
HGNC11848
UniprotO60603

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002224
TAS, IEA
Genome Projecttoll-like receptor signaling pathway
GO:0002237
IEA
Genome Projectresponse to molecule of bacterial origin
GO:0002238
IEA
Genome Projectresponse to molecule of fungal origin
GO:0002374
IMP
Genome Projectcytokine secretion involved in immune response
GO:0002376
IEA
Genome Projectimmune system process
GO:0002687
IEA
Genome Projectpositive regulation of leukocyte migration
GO:0002730
IEA
Genome Projectregulation of dendritic cell cytokine production
GO:0002752
IEA
Genome Projectcell surface pattern recognition receptor signaling pathway
GO:0002755
TAS, IEA
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0006915
TAS
Genome Projectapoptotic process
GO:0006954
IEA
Genome Projectinflammatory response
GO:0006955
TAS, IEA
Genome Projectimmune response
GO:0007165
TAS, IEA
Genome Projectsignal transduction
GO:0007252
IDA
Genome ProjectI-kappaB phosphorylation
GO:0009617
IEA
Genome Projectresponse to bacterium
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0030177
IMP
Genome Projectpositive regulation of Wnt signaling pathway
GO:0031663
TAS
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0032494
IEA
Genome Projectresponse to peptidoglycan
GO:0032613
IDA
Genome Projectinterleukin-10 production
GO:0032695
IEA
Genome Projectnegative regulation of interleukin-12 production
GO:0032700
IEA
Genome Projectnegative regulation of interleukin-17 production
GO:0032722
IDA
Genome Projectpositive regulation of chemokine production
GO:0032728
ISS
Genome Projectpositive regulation of interferon-beta production
GO:0032735
ISS
Genome Projectpositive regulation of interleukin-12 production
GO:0032741
ISS
Genome Projectpositive regulation of interleukin-18 production
GO:0032755
IDA
Genome Projectpositive regulation of interleukin-6 production
GO:0032757
IDA
Genome Projectpositive regulation of interleukin-8 production
GO:0032760
ISS
IEA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0034123
IDA
Genome Projectpositive regulation of toll-like receptor signaling pathway
GO:0034134
TAS, IEA
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0042346
IDA
Genome Projectpositive regulation of NF-kappaB import into nucleus
GO:0042495
IDA
Genome Projectdetection of triacyl bacterial lipopeptide
GO:0042496
IDA
Genome Projectdetection of diacyl bacterial lipopeptide
GO:0042535
IEA
Genome Projectpositive regulation of tumor necrosis factor biosynthetic process
GO:0042892
IEA
Genome Projectchloramphenicol transport
GO:0044130
IEA
Genome Projectnegative regulation of growth of symbiont in host
GO:0045087
TAS, IEA
Genome Projectinnate immune response
GO:0045429
IEA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045944
ISS
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0050707
IEA
Genome Projectregulation of cytokine secretion
GO:0050715
IEA
Genome Projectpositive regulation of cytokine secretion
GO:0050729
IC, IEA
Genome Projectpositive regulation of inflammatory response
GO:0050830
IDA
Genome Projectdefense response to Gram-positive bacterium
GO:0051092
IDA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051770
ISS
Genome Projectpositive regulation of nitric-oxide synthase biosynthetic process
GO:0052063
IEA
Genome Projectinduction by symbiont of defense-related host nitric oxide production
GO:0060907
IEA
Genome Projectpositive regulation of macrophage cytokine production
GO:0071221
TAS, IEA
Genome Projectcellular response to bacterial lipopeptide
GO:0071223
IDA
Genome Projectcellular response to lipoteichoic acid
GO:0071224
IEA
Genome Projectcellular response to peptidoglycan
GO:0071726
IDA
Genome Projectcellular response to diacyl bacterial lipopeptide
GO:0071727
IDA
Genome Projectcellular response to triacyl bacterial lipopeptide

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001530
IDA
Genome Projectlipopolysaccharide binding
GO:0001875
TAS
Genome Projectlipopolysaccharide receptor activity
GO:0004872
IDA
TAS
Genome Projectreceptor activity
GO:0004888
IEA
Genome Projecttransmembrane signaling receptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008329
IDA
Genome Projectsignaling pattern recognition receptor activity
GO:0042497
IDA
IEA
Genome Projecttriacyl lipopeptide binding
GO:0042498
IEA
Genome Projectdiacyl lipopeptide binding
GO:0042834
IDA
Genome Projectpeptidoglycan binding
GO:0046982
IDA
Genome Projectprotein heterodimerization activity
GO:0070891
IEA
Genome Projectlipoteichoic acid binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005886
IDA
TAS
Genome Projectplasma membrane
GO:0005887
TAS
Genome Projectintegral component of plasma membrane
GO:0009897
IEA
Genome Projectexternal side of plasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0031226
IDA
Genome Projectintrinsic component of plasma membrane
GO:0035354
IDA
Genome ProjectToll-like receptor 1-Toll-like receptor 2 protein complex
GO:0035355
IEA
Genome ProjectToll-like receptor 2-Toll-like receptor 6 protein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000157Toll/interleukin-1 receptor homology (TIR) domain
IPR000483Cysteine-rich flanking region, C-terminal
IPR001611Leucine-rich repeat
IPR003591Leucine-rich repeat, typical subtype
IPR017241Toll-like receptor
IPR027185Toll-like receptor 2

No MapMan annotations defined for this gene.