Gene: ENSG00000137275 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000137275
Transcript Identifier
ENST00000380409
Gene Type
Coding gene
Location
6 : 3076824-3113339 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P068712
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
receptor (TNFRSF)-interacting serine-threonine kinase 1

Identifiers

Type Value
pidENSP00000369773
HGNC10019
UniprotQ13546
UniprotA0A024QZU0

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007165
IEA
Genome Projectsignal transduction
GO:0010942
IEA
Genome Projectpositive regulation of cell death
GO:0016310
IEA
Genome Projectphosphorylation
GO:0042327
IEA
Genome Projectpositive regulation of phosphorylation
GO:0043410
IEA
Genome Projectpositive regulation of MAPK cascade
GO:0051291
IMP
IEA
Genome Projectprotein heterooligomerization
GO:0051347
IEA
Genome Projectpositive regulation of transferase activity
GO:0060545
IMP
IEA
Genome Projectpositive regulation of necroptotic process
GO:0070231
ISS
IEA
Genome ProjectT cell apoptotic process
GO:0071363
IEA
Genome Projectcellular response to growth factor stimulus
GO:1901026
IEA
Genome Projectripoptosome assembly involved in necroptotic process
GO:2000377
IEA
Genome Projectregulation of reactive oxygen species metabolic process
GO:2001240
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0001934
IMP
Genome Projectpositive regulation of protein phosphorylation
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0006915
IMP
TAS
Genome Projectapoptotic process
GO:0006919
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166
TAS
Genome Projectcell surface receptor signaling pathway
GO:0007257
TAS
Genome Projectactivation of JUN kinase activity
GO:0010939
TAS
Genome Projectregulation of necrotic cell death
GO:0012501
TAS, IEA
Genome Projectprogrammed cell death
GO:0032481
TAS
Genome Projectpositive regulation of type I interferon production
GO:0032757
IDA
Genome Projectpositive regulation of interleukin-8 production
GO:0032760
IDA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0033209
TAS, IC
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034612
IMP
Genome Projectresponse to tumor necrosis factor
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0036289
IDA
Genome Projectpeptidyl-serine autophosphorylation
GO:0043065
IDA, IMP
Genome Projectpositive regulation of apoptotic process
GO:0043068
IMP
Genome Projectpositive regulation of programmed cell death
GO:0043123
IDA, IEP
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124
IMP
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043154
TAS
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044257
IDA
Genome Projectcellular protein catabolic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045651
IMP
Genome Projectpositive regulation of macrophage differentiation
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046330
IDA
Genome Projectpositive regulation of JNK cascade
GO:0046777
IDA
Genome Projectprotein autophosphorylation
GO:0051092
IMP
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051260
IDA
Genome Projectprotein homooligomerization
GO:0070266
IMP
TAS
Genome Projectnecroptotic process
GO:0070926
IMP
Genome Projectregulation of ATP:ADP antiporter activity
GO:0071356
IDA
Genome Projectcellular response to tumor necrosis factor
GO:0071550
TAS
Genome Projectdeath-inducing signaling complex assembly
GO:0097191
IDA, IMP
TAS
Genome Projectextrinsic apoptotic signaling pathway
GO:0097296
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097300
TAS
Genome Projectprogrammed necrotic cell death
GO:0097343
IMP
Genome Projectripoptosome assembly
GO:0097527
IMP
ISS
Genome Projectnecroptotic signaling pathway
GO:1902041
TAS
Genome Projectregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1990000
IMP
Genome Projectamyloid fibril formation
GO:2000379
TAS
Genome Projectpositive regulation of reactive oxygen species metabolic process
GO:2001237
IMP
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway
GO:2001238
IMP
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004672
IDA, IMP
IEA
Genome Projectprotein kinase activity
GO:0005123
IPI
IEA
Genome Projectdeath receptor binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004674
IDA
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0016740
IEA
Genome Projecttransferase activity
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0032403
IDA
Genome Projectprotein complex binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0070513
IPI
Genome Projectdeath domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043234
IEA
Genome Projectprotein complex
GO:0045121
IEA
Genome Projectmembrane raft
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0031264
IDA
Genome Projectdeath-inducing signaling complex
GO:0043235
IDA
Genome Projectreceptor complex
GO:0097342
IDA
Genome Projectripoptosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000488Death domain
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR011029Death-like domain
IPR025735RHIM domain

No MapMan annotations defined for this gene.