Gene: ENSG00000136869 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000136869
Transcript Identifier
ENST00000355622
Gene Type
Coding gene
Location
9 : 117704473-117714648 : positive

Family Information

Homologous gene family
HOM03P004593
(20 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P066209
(2 genes in 2 species)
specific family

Descriptions

gene_descr
toll-like receptor 4

Identifiers

Type Value
pidENSP00000363089
HGNC11850
UniprotO00206

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
ISS
IEA
Genome Projectactivation of MAPK activity
GO:0002218
IEA
Genome Projectactivation of innate immune response
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002322
IEA
Genome ProjectB cell proliferation involved in immune response
GO:0002376
IEA
Genome Projectimmune system process
GO:0002537
IEA
Genome Projectnitric oxide production involved in inflammatory response
GO:0002730
IEA
Genome Projectregulation of dendritic cell cytokine production
GO:0002755
TAS, IEA
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0006915
TAS
Genome Projectapoptotic process
GO:0006954
IEA
Genome Projectinflammatory response
GO:0006955
TAS
Genome Projectimmune response
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007249
TAS
Genome ProjectI-kappaB kinase/NF-kappaB signaling
GO:0007252
IDA
Genome ProjectI-kappaB phosphorylation
GO:0009617
IEA
Genome Projectresponse to bacterium
GO:0010572
ISS
IEA
Genome Projectpositive regulation of platelet activation
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0016046
NAS
Genome Projectdetection of fungus
GO:0030890
IEA
Genome Projectpositive regulation of B cell proliferation
GO:0031663
IDA, IGI
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0032496
IDA
IC
Genome Projectresponse to lipopolysaccharide
GO:0032497
IDA
Genome Projectdetection of lipopolysaccharide
GO:0032609
IEA
Genome Projectinterferon-gamma production
GO:0032689
ISS
IEA
Genome Projectnegative regulation of interferon-gamma production
GO:0032700
ISS
IEA
Genome Projectnegative regulation of interleukin-17 production
GO:0032707
ISS
IEA
Genome Projectnegative regulation of interleukin-23 production
GO:0032715
ISS
IEA
Genome Projectnegative regulation of interleukin-6 production
GO:0032720
ISS
IEA
Genome Projectnegative regulation of tumor necrosis factor production
GO:0032722
IDA
Genome Projectpositive regulation of chemokine production
GO:0032727
ISS
IEA
Genome Projectpositive regulation of interferon-alpha production
GO:0032728
ISS
IEA
Genome Projectpositive regulation of interferon-beta production
GO:0032729
ISS
IEA
Genome Projectpositive regulation of interferon-gamma production
GO:0032732
ISS
IEA
Genome Projectpositive regulation of interleukin-1 production
GO:0032733
ISS
IEA
Genome Projectpositive regulation of interleukin-10 production
GO:0032735
ISS
IEA
Genome Projectpositive regulation of interleukin-12 production
GO:0032755
IDA
Genome Projectpositive regulation of interleukin-6 production
GO:0032757
IDA
Genome Projectpositive regulation of interleukin-8 production
GO:0032760
ISS
IEA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032874
IEA
Genome Projectpositive regulation of stress-activated MAPK cascade
GO:0034134
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS, IEA
Genome Projecttoll-like receptor 4 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0042088
NAS
Genome ProjectT-helper 1 type immune response
GO:0042116
IMP
IEA
Genome Projectmacrophage activation
GO:0042346
IDA
Genome Projectpositive regulation of NF-kappaB import into nucleus
GO:0042535
IDA
Genome Projectpositive regulation of tumor necrosis factor biosynthetic process
GO:0042742
TAS
Genome Projectdefense response to bacterium
GO:0043123
IEA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084
IDA
Genome Projectpositive regulation of interleukin-12 biosynthetic process
GO:0045087
TAS, IEA
Genome Projectinnate immune response
GO:0045348
IEA
Genome Projectpositive regulation of MHC class II biosynthetic process
GO:0045359
IEA
Genome Projectpositive regulation of interferon-beta biosynthetic process
GO:0045416
IDA
Genome Projectpositive regulation of interleukin-8 biosynthetic process
GO:0045429
IEA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045671
NAS
Genome Projectnegative regulation of osteoclast differentiation
GO:0045944
ISS
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046330
IEA
Genome Projectpositive regulation of JNK cascade
GO:0050671
IEA
Genome Projectpositive regulation of lymphocyte proliferation
GO:0050707
IEA
Genome Projectregulation of cytokine secretion
GO:0050727
IEA
Genome Projectregulation of inflammatory response
GO:0050729
IC
Genome Projectpositive regulation of inflammatory response
GO:0050829
IC, IEA
Genome Projectdefense response to Gram-negative bacterium
GO:0051092
IDA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051770
ISS
IEA
Genome Projectpositive regulation of nitric-oxide synthase biosynthetic process
GO:0060729
ISS
IEA
Genome Projectintestinal epithelial structure maintenance
GO:0060907
IEA
Genome Projectpositive regulation of macrophage cytokine production
GO:0070373
ISS
IEA
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0070374
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0070430
IEA
Genome Projectpositive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434
IEA
Genome Projectpositive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071222
ISS
IEA
Genome Projectcellular response to lipopolysaccharide
GO:0071223
IEA
Genome Projectcellular response to lipoteichoic acid
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus
GO:0097191
TAS
Genome Projectextrinsic apoptotic signaling pathway
GO:0097296
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001530
IMP
NAS
Genome Projectlipopolysaccharide binding
GO:0001875
IDA
Genome Projectlipopolysaccharide receptor activity
GO:0004872
TAS
Genome Projectreceptor activity
GO:0004888
NAS, IEA
Genome Projecttransmembrane signaling receptor activity
GO:0005515
IPI
Genome Projectprotein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005887
IDA
Genome Projectintegral component of plasma membrane
GO:0009897
IDA
Genome Projectexternal side of plasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0010008
TAS
Genome Projectendosome membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0031226
IDA
Genome Projectintrinsic component of plasma membrane
GO:0046696
IDA
IEA
Genome Projectlipopolysaccharide receptor complex
GO:0048471
IDA
Genome Projectperinuclear region of cytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000157Toll/interleukin-1 receptor homology (TIR) domain
IPR000483Cysteine-rich flanking region, C-terminal
IPR001611Leucine-rich repeat
IPR003591Leucine-rich repeat, typical subtype
IPR027168Toll-like receptor 4

No MapMan annotations defined for this gene.