Gene: ENSG00000136848 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000136848
Transcript Identifier
ENST00000408936
Gene Type
Coding gene
Location
9 : 121651776-121782498 : positive

Family Information

Homologous gene family
HOM03P003334
(29 genes in 7 species)
specific family
Orthologous gene family
ORTHO03P012054
(7 genes in 3 species)
specific family

Descriptions

gene_descr
DAB2 interacting protein

Identifiers

Type Value
pidENSP00000386183
HGNC17294
UniprotQ5VWQ8

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IDA, IMP
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000185
IDA
Genome Projectactivation of MAPKKK activity
GO:0001525
IEA
Genome Projectangiogenesis
GO:0001933
IMP
ISS
Genome Projectnegative regulation of protein phosphorylation
GO:0002376
IEA
Genome Projectimmune system process
GO:0006915
IEA
Genome Projectapoptotic process
GO:0006927
TAS
Genome Projecttransformed cell apoptotic process
GO:0006954
IEA
Genome Projectinflammatory response
GO:0006986
IEA
Genome Projectresponse to unfolded protein
GO:0006987
TAS
Genome Projectactivation of signaling protein activity involved in unfolded protein response
GO:0007049
IEA
Genome Projectcell cycle
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007252
ISS
IEA
Genome ProjectI-kappaB phosphorylation
GO:0007257
IDA
Genome Projectactivation of JUN kinase activity
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0008285
IDA
IEA
Genome Projectnegative regulation of cell proliferation
GO:0008625
IMP
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0010596
IMP
Genome Projectnegative regulation of endothelial cell migration
GO:0010633
IMP
TAS
Genome Projectnegative regulation of epithelial cell migration
GO:0010719
IDA, IMP
Genome Projectnegative regulation of epithelial to mesenchymal transition
GO:0010976
ISS
IEA
Genome Projectpositive regulation of neuron projection development
GO:0014067
IDA
Genome Projectnegative regulation of phosphatidylinositol 3-kinase signaling
GO:0016525
IDA
IEA
Genome Projectnegative regulation of angiogenesis
GO:0021814
ISS
IEA
Genome Projectcell motility involved in cerebral cortex radial glia guided migration
GO:0021819
ISS
IEA
Genome Projectlayer formation in cerebral cortex
GO:0030948
IMP
IEA
Genome Projectnegative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032088
IMP
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0034144
IDA
Genome Projectnegative regulation of toll-like receptor 4 signaling pathway
GO:0034260
IMP
ISS
Genome Projectnegative regulation of GTPase activity
GO:0035148
IMP
Genome Projecttube formation
GO:0035414
ISS
IEA
Genome Projectnegative regulation of catenin import into nucleus
GO:0035924
IDA
ISS
Genome Projectcellular response to vascular endothelial growth factor stimulus
GO:0036324
ISS
IEA
Genome Projectvascular endothelial growth factor receptor-2 signaling pathway
GO:0038026
IEA
Genome Projectreelin-mediated signaling pathway
GO:0040008
IEA
Genome Projectregulation of growth
GO:0042059
ISS
Genome Projectnegative regulation of epidermal growth factor receptor signaling pathway
GO:0043065
IDA
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043087
ISS
IEA
Genome Projectregulation of GTPase activity
GO:0043122
ISS
IEA
Genome Projectregulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124
IDA
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254
IDA
Genome Projectregulation of protein complex assembly
GO:0043407
IDA, IMP
Genome Projectnegative regulation of MAP kinase activity
GO:0043410
IDA
Genome Projectpositive regulation of MAPK cascade
GO:0043497
IDA
Genome Projectregulation of protein heterodimerization activity
GO:0043507
IDA
Genome Projectpositive regulation of JUN kinase activity
GO:0043547
IBA
Genome Projectpositive regulation of GTPase activity
GO:0043553
IDA
Genome Projectnegative regulation of phosphatidylinositol 3-kinase activity
GO:0044257
IDA
Genome Projectcellular protein catabolic process
GO:0045087
IEA
Genome Projectinnate immune response
GO:0045732
ISS
IEA
Genome Projectpositive regulation of protein catabolic process
GO:0045892
IMP
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046330
IDA
Genome Projectpositive regulation of JNK cascade
GO:0046580
IBA
IC
Genome Projectnegative regulation of Ras protein signal transduction
GO:0048147
ISS
IEA
Genome Projectnegative regulation of fibroblast proliferation
GO:0048812
ISS
IEA
Genome Projectneuron projection morphogenesis
GO:0050680
IMP
Genome Projectnegative regulation of epithelial cell proliferation
GO:0070059
ISS
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070317
IDA
Genome Projectnegative regulation of G0 to G1 transition
GO:0070373
IDA
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0071158
IDA
Genome Projectpositive regulation of cell cycle arrest
GO:0071222
IDA
Genome Projectcellular response to lipopolysaccharide
GO:0071347
IDA
Genome Projectcellular response to interleukin-1
GO:0071356
IDA
Genome Projectcellular response to tumor necrosis factor
GO:0071364
ISS
Genome Projectcellular response to epidermal growth factor stimulus
GO:0071901
IDA, IMP
Genome Projectnegative regulation of protein serine/threonine kinase activity
GO:0071902
IDA, IMP
Genome Projectpositive regulation of protein serine/threonine kinase activity
GO:0072577
TAS
Genome Projectendothelial cell apoptotic process
GO:0090090
IMP
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090129
ISS
IEA
Genome Projectpositive regulation of synapse maturation
GO:1900006
ISS
IEA
Genome Projectpositive regulation of dendrite development
GO:1900744
ISS
IEA
Genome Projectregulation of p38MAPK cascade
GO:1900747
ISS
IEA
Genome Projectnegative regulation of vascular endothelial growth factor signaling pathway
GO:1901800
IMP
Genome Projectpositive regulation of proteasomal protein catabolic process
GO:1903896
TAS
Genome Projectpositive regulation of IRE1-mediated unfolded protein response
GO:2000599
IDA
Genome Projectnegative regulation of cyclin catabolic process
GO:2001224
ISS
IEA
Genome Projectpositive regulation of neuron migration
GO:2001235
IDA
Genome Projectpositive regulation of apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005096
IBA
IEA
Genome ProjectGTPase activator activity
GO:0005123
IPI
Genome Projectdeath receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0017124
IDA
Genome ProjectSH3 domain binding
GO:0019900
IPI
Genome Projectkinase binding
GO:0019901
IDA, IPI
Genome Projectprotein kinase binding
GO:0031434
IPI
Genome Projectmitogen-activated protein kinase kinase binding
GO:0031435
IPI
Genome Projectmitogen-activated protein kinase kinase kinase binding
GO:0032266
IDA
Genome Projectphosphatidylinositol-3-phosphate binding
GO:0032403
IDA
Genome Projectprotein complex binding
GO:0035591
IDA
Genome Projectsignaling adaptor activity
GO:0036312
IDA
Genome Projectphosphatidylinositol 3-kinase regulatory subunit binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042803
IPI
Genome Projectprotein homodimerization activity
GO:0043184
IPI
Genome Projectvascular endothelial growth factor receptor 2 binding
GO:0043548
IDA
Genome Projectphosphatidylinositol 3-kinase binding
GO:0051721
IDA
Genome Projectprotein phosphatase 2A binding
GO:0070273
IDA
Genome Projectphosphatidylinositol-4-phosphate binding
GO:0071889
IDA
Genome Project14-3-3 protein binding
GO:0035662
IDA
Genome ProjectToll-like receptor 4 binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005886
IDA
IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0030139
IDA
Genome Projectendocytic vesicle
GO:0030424
ISS
IEA
Genome Projectaxon
GO:0030425
IEA
Genome Projectdendrite
GO:0031235
IBA
Genome Projectintrinsic component of the cytoplasmic side of the plasma membrane
GO:0032809
ISS
IEA
Genome Projectneuronal cell body membrane
GO:0042995
IEA
Genome Projectcell projection
GO:0043025
ISS
IEA
Genome Projectneuronal cell body
GO:0044300
ISS
IEA
Genome Projectcerebellar mossy fiber
GO:0044301
ISS
IEA
Genome Projectclimbing fiber
GO:0070062
IDA
Genome Projectextracellular exosome
GO:1990032
ISS
IEA
Genome Projectparallel fiber
GO:1990597
IDA
Genome ProjectAIP1-IRE1 complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000008C2 domain
IPR001849Pleckstrin homology domain
IPR001936Ras GTPase-activating protein
IPR008936Rho GTPase activation protein
IPR011993PH domain-like
IPR021887Domain of unknown function DUF3498
IPR023152Ras GTPase-activating protein, conserved site
IPR030403Disabled homologue 2-interacting protein

No MapMan annotations defined for this gene.