Gene: ENSG00000136689 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000136689
Transcript Identifier
ENST00000259206
Gene Type
Coding gene
Location
2 : 113118019-113132871 : positive

Family Information

Homologous gene family
HOM03P021245
(4 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P046120
(2 genes in 1 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
interleukin 1 receptor antagonist

Identifiers

Type Value
pidENSP00000259206
HGNC6000
UniprotP18510

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001660
IBA
IEA
Genome Projectfever generation
GO:0001960
IDA
Genome Projectnegative regulation of cytokine-mediated signaling pathway
GO:0002437
IBA
Genome Projectinflammatory response to antigenic stimulus
GO:0002439
IEA
Genome Projectchronic inflammatory response to antigenic stimulus
GO:0006629
IEA
Genome Projectlipid metabolic process
GO:0006953
IDA
Genome Projectacute-phase response
GO:0006955
NAS
Genome Projectimmune response
GO:0007565
IEA
Genome Projectfemale pregnancy
GO:0007613
IEA
Genome Projectmemory
GO:0010243
IEA
Genome Projectresponse to organonitrogen compound
GO:0014050
IEA
Genome Projectnegative regulation of glutamate secretion
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0014823
IEA
Genome Projectresponse to activity
GO:0019233
IEA
Genome Projectsensory perception of pain
GO:0019752
IEA
Genome Projectcarboxylic acid metabolic process
GO:0030073
IEA
Genome Projectinsulin secretion
GO:0030336
IEA
Genome Projectnegative regulation of cell migration
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0034115
IDA
Genome Projectnegative regulation of heterotypic cell-cell adhesion
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042594
IEA
Genome Projectresponse to starvation
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043507
IEA
Genome Projectpositive regulation of JUN kinase activity
GO:0045837
IEA
Genome Projectnegative regulation of membrane potential
GO:0051384
IDA
Genome Projectresponse to glucocorticoid
GO:0070555
IEA
Genome Projectresponse to interleukin-1
GO:0070670
IEA
Genome Projectresponse to interleukin-4
GO:0071874
IEA
Genome Projectcellular response to norepinephrine stimulus
GO:2000660
IDA
Genome Projectnegative regulation of interleukin-1-mediated signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005125
IBA
Genome Projectcytokine activity
GO:0005149
IDA
IEA
Genome Projectinterleukin-1 receptor binding
GO:0005150
IPI
Genome Projectinterleukin-1, Type I receptor binding
GO:0005151
IPI
Genome Projectinterleukin-1, Type II receptor binding
GO:0005152
IDA
TAS, IEA
Genome Projectinterleukin-1 receptor antagonist activity
GO:0045352
IDA
Genome Projectinterleukin-1 Type I receptor antagonist activity
GO:0045353
IDA
Genome Projectinterleukin-1 Type II receptor antagonist activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
IDA
IEA
Genome Projectextracellular space
GO:0005622
NAS
Genome Projectintracellular
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005886
TAS
Genome Projectplasma membrane
GO:0031982
IEA
Genome Projectvesicle
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000975Interleukin-1 family
IPR003297Interleukin-1 receptor antagonist / Interleukin-36
IPR008996Cytokine, IL-1-like
IPR020877Interleukin-1 conserved site
IPR027166Interleukin-1 receptor antagonist protein

No MapMan annotations defined for this gene.