Gene: ENSG00000136603 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000136603
Transcript Identifier
ENST00000458537
Gene Type
Coding gene
Location
3 : 170360332-170392417 : positive

Family Information

Homologous gene family
HOM03P010259
(8 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P071191
(2 genes in 2 species)
specific family

Descriptions

gene_descr
SKI-like proto-oncogene

Identifiers

Type Value
pidENSP00000415243
HGNC10897
UniprotP12757

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IDA
TAS, IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001825
IEA
Genome Projectblastocyst formation
GO:0002260
IEA
Genome Projectlymphocyte homeostasis
GO:0006351
TAS
Genome Projecttranscription, DNA-templated
GO:0006367
TAS
Genome Projecttranscription initiation from RNA polymerase II promoter
GO:0007050
ISS
IEA
Genome Projectcell cycle arrest
GO:0007179
TAS, IEA
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007283
IEA
Genome Projectspermatogenesis
GO:0007519
IDA
Genome Projectskeletal muscle tissue development
GO:0010467
TAS
Genome Projectgene expression
GO:0030512
IDA
IEA
Genome Projectnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0034097
IEA
Genome Projectresponse to cytokine
GO:0042981
ISS, IBA
Genome Projectregulation of apoptotic process
GO:0045596
ISS
IEA
Genome Projectnegative regulation of cell differentiation
GO:0046677
IEP
Genome Projectresponse to antibiotic
GO:0050772
IMP
IEA
Genome Projectpositive regulation of axonogenesis
GO:0070207
IDA
Genome Projectprotein homotrimerization
GO:0070208
IDA
Genome Projectprotein heterotrimerization
GO:0070306
IEA
Genome Projectlens fiber cell differentiation
GO:0070848
IDA
Genome Projectresponse to growth factor
GO:1902043
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902231
IEA
Genome Projectpositive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000978
IDA
Genome ProjectRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078
IDA
Genome Projecttranscriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003682
ISS
IEA
Genome Projectchromatin binding
GO:0003714
IDA
Genome Projecttranscription corepressor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0019904
IPI
Genome Projectprotein domain specific binding
GO:0032403
IDA
Genome Projectprotein complex binding
GO:0046332
IPI
IEA
Genome ProjectSMAD binding
GO:0003677
IDA
Genome ProjectDNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001669
IEA
Genome Projectacrosomal vesicle
GO:0005634
IDA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005737
IDA
Genome Projectcytoplasm
GO:0016605
IDA
Genome ProjectPML body
GO:0043234
IDA
Genome Projectprotein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR003380Transforming protein Ski
IPR009061Putative DNA-binding domain
IPR010919SAND domain-like
IPR014890c-SKI SMAD4-binding domain
IPR023216Transcription regulator SKI/SnoN
IPR028373Ski-related oncogene Sno

No MapMan annotations defined for this gene.