Gene: ENSG00000136244 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000136244
Transcript Identifier
ENST00000258743
Gene Type
Coding gene
Location
7 : 22727263-22731573 : positive

Family Information

Homologous gene family
HOM03P034495
(2 genes in 2 species)
specific family

Descriptions

gene_descr
interleukin 6

Identifiers

Type Value
pidENSP00000258743
HGNC6018
UniprotP05231
UniprotQ75MH2

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001781
IDA
Genome Projectneutrophil apoptotic process
GO:0001878
IEA
Genome Projectresponse to yeast
GO:0002262
IEA
Genome Projectmyeloid cell homeostasis
GO:0002384
IDA
TAS
Genome Projecthepatic immune response
GO:0002446
TAS
Genome Projectneutrophil mediated immunity
GO:0002548
IC
Genome Projectmonocyte chemotaxis
GO:0002675
IDA
Genome Projectpositive regulation of acute inflammatory response
GO:0002690
TAS
Genome Projectpositive regulation of leukocyte chemotaxis
GO:0006469
IEA
Genome Projectnegative regulation of protein kinase activity
GO:0006953
TAS, IEA
Genome Projectacute-phase response
GO:0006954
IDA
Genome Projectinflammatory response
GO:0006955
IEA
Genome Projectimmune response
GO:0006959
IC
Genome Projecthumoral immune response
GO:0007568
IEA
Genome Projectaging
GO:0008284
IDA, IMP
Genome Projectpositive regulation of cell proliferation
GO:0008285
TAS, IEA
Genome Projectnegative regulation of cell proliferation
GO:0008360
IEA
Genome Projectregulation of cell shape
GO:0009408
IEA
Genome Projectresponse to heat
GO:0009409
IEA
Genome Projectresponse to cold
GO:0009611
IEA
Genome Projectresponse to wounding
GO:0009612
IEA
Genome Projectresponse to mechanical stimulus
GO:0009617
IEA
Genome Projectresponse to bacterium
GO:0010574
IDA
Genome Projectregulation of vascular endothelial growth factor production
GO:0010628
IEA
Genome Projectpositive regulation of gene expression
GO:0010888
NAS
Genome Projectnegative regulation of lipid storage
GO:0010996
IEA
Genome Projectresponse to auditory stimulus
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0016049
IEA
Genome Projectcell growth
GO:0019221
IDA
Genome Projectcytokine-mediated signaling pathway
GO:0030168
TAS
Genome Projectplatelet activation
GO:0031000
IEA
Genome Projectresponse to caffeine
GO:0031018
ISS
IEA
Genome Projectendocrine pancreas development
GO:0031175
IMP
Genome Projectneuron projection development
GO:0031667
IEA
Genome Projectresponse to nutrient levels
GO:0032494
NAS
Genome Projectresponse to peptidoglycan
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0032722
IDA
NAS
Genome Projectpositive regulation of chemokine production
GO:0032755
IDA
Genome Projectpositive regulation of interleukin-6 production
GO:0032868
IEA
Genome Projectresponse to insulin
GO:0032966
IDA
Genome Projectnegative regulation of collagen biosynthetic process
GO:0033138
IDA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0033160
IEA
Genome Projectpositive regulation of protein import into nucleus, translocation
GO:0034097
IEA
Genome Projectresponse to cytokine
GO:0042060
IEA
Genome Projectwound healing
GO:0042102
IDA
Genome Projectpositive regulation of T cell proliferation
GO:0042110
IEA
Genome ProjectT cell activation
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042517
IDA
IEA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042593
IEA
Genome Projectglucose homeostasis
GO:0042832
IEA
Genome Projectdefense response to protozoan
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0043066
IDA
Genome Projectnegative regulation of apoptotic process
GO:0043154
IEA
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043200
IEA
Genome Projectresponse to amino acid
GO:0043410
IDA
Genome Projectpositive regulation of MAPK cascade
GO:0045079
ISS
IEA
Genome Projectnegative regulation of chemokine biosynthetic process
GO:0045188
IEA
Genome Projectregulation of circadian sleep/wake cycle, non-REM sleep
GO:0045429
IEA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045454
IEA
Genome Projectcell redox homeostasis
GO:0045599
NAS
Genome Projectnegative regulation of fat cell differentiation
GO:0045630
IEA
Genome Projectpositive regulation of T-helper 2 cell differentiation
GO:0045666
IEA
Genome Projectpositive regulation of neuron differentiation
GO:0045669
TAS
Genome Projectpositive regulation of osteoblast differentiation
GO:0045721
IEA
Genome Projectnegative regulation of gluconeogenesis
GO:0045727
IDA
Genome Projectpositive regulation of translation
GO:0045740
IEA
Genome Projectpositive regulation of DNA replication
GO:0045765
IC
Genome Projectregulation of angiogenesis
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA
ISS
NAS
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046427
IDA
IEA
Genome Projectpositive regulation of JAK-STAT cascade
GO:0046677
IEA
Genome Projectresponse to antibiotic
GO:0046716
IEA
Genome Projectmuscle cell cellular homeostasis
GO:0046849
IEA
Genome Projectbone remodeling
GO:0046888
IEA
Genome Projectnegative regulation of hormone secretion
GO:0048635
IEA
Genome Projectnegative regulation of muscle organ development
GO:0048661
IDA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0050679
IEA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050710
IEA
Genome Projectnegative regulation of cytokine secretion
GO:0050731
IDA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050829
TAS
Genome Projectdefense response to Gram-negative bacterium
GO:0050830
TAS
Genome Projectdefense response to Gram-positive bacterium
GO:0050871
IDA
Genome Projectpositive regulation of B cell activation
GO:0051024
IDA
Genome Projectpositive regulation of immunoglobulin secretion
GO:0051091
IDA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384
IDA
Genome Projectresponse to glucocorticoid
GO:0051592
IEA
Genome Projectresponse to calcium ion
GO:0051602
IEA
Genome Projectresponse to electrical stimulus
GO:0051607
IDA
Genome Projectdefense response to virus
GO:0051897
IEA
Genome Projectpositive regulation of protein kinase B signaling
GO:0051971
IEA
Genome Projectpositive regulation of transmission of nerve impulse
GO:0060445
IEA
Genome Projectbranching involved in salivary gland morphogenesis
GO:0060664
IEA
Genome Projectepithelial cell proliferation involved in salivary gland morphogenesis
GO:0070091
ISS
IEA
Genome Projectglucagon secretion
GO:0070102
IDA
Genome Projectinterleukin-6-mediated signaling pathway
GO:0070301
IDA
Genome Projectcellular response to hydrogen peroxide
GO:0070374
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0071222
IMP
IEA
Genome Projectcellular response to lipopolysaccharide
GO:0071347
IEA
Genome Projectcellular response to interleukin-1
GO:0071354
NAS
Genome Projectcellular response to interleukin-6
GO:0071356
IEA
Genome Projectcellular response to tumor necrosis factor
GO:0071549
IEA
Genome Projectcellular response to dexamethasone stimulus
GO:0072540
ISS
IEA
Genome ProjectT-helper 17 cell lineage commitment
GO:1901215
IEA
Genome Projectnegative regulation of neuron death
GO:2000366
IC
Genome Projectpositive regulation of STAT protein import into nucleus
GO:2000676
TAS
Genome Projectpositive regulation of type B pancreatic cell apoptotic process
GO:0051092
IDA
Genome Projectpositive regulation of NF-kappaB transcription factor activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005102
IEA
Genome Projectreceptor binding
GO:0005125
IDA
ISS
NAS, IEA
Genome Projectcytokine activity
GO:0005138
IPI
TAS, NAS, IEA
Genome Projectinterleukin-6 receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008083
IDA
TAS, IEA
Genome Projectgrowth factor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005615
IDA
IEA
Genome Projectextracellular space
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005896
IDA
Genome Projectinterleukin-6 receptor complex
GO:0009897
IEA
Genome Projectexternal side of plasma membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR003574Interleukin-6
IPR009079Four-helical cytokine-like, core
IPR012351Four-helical cytokine, core
IPR030473Interleukin-6/GCSF/MGF, conserved site
IPR030474Interleukin-6/GCSF/MGF

No MapMan annotations defined for this gene.