Gene: ENSG00000136238 (Homo sapiens)

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Gene Identifier
ENSG00000136238
Transcript Identifier
ENST00000356142
Gene Type
Coding gene
Location
7 : 6374736-6402446 : positive

Family Information

Homologous gene family
HOM03P000013
(1389 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P000289
(56 genes in 27 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

Identifiers

Type Value
pidENSP00000348461
HGNC9801
UniprotP63000
UniprotA4D2P0

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002093
IEA
Genome Projectauditory receptor cell morphogenesis
GO:0003382
IEA
Genome Projectepithelial cell morphogenesis
GO:0006897
IEA
Genome Projectendocytosis
GO:0006911
IEA
Genome Projectphagocytosis, engulfment
GO:0006972
IEA
Genome Projecthyperosmotic response
GO:0007010
IEA
Genome Projectcytoskeleton organization
GO:0007155
TAS, IEA
Genome Projectcell adhesion
GO:0007186
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007264
TAS, IEA
Genome Projectsmall GTPase mediated signal transduction
GO:0007411
TAS, IEA
Genome Projectaxon guidance
GO:0008152
IEA
Genome Projectmetabolic process
GO:0010762
IEA
Genome Projectregulation of fibroblast migration
GO:0014041
IEA
Genome Projectregulation of neuron maturation
GO:0016358
IEA
Genome Projectdendrite development
GO:0016477
IEA
Genome Projectcell migration
GO:0021799
IEA
Genome Projectcerebral cortex radially oriented cell migration
GO:0021831
IEA
Genome Projectembryonic olfactory bulb interneuron precursor migration
GO:0021894
IEA
Genome Projectcerebral cortex GABAergic interneuron development
GO:0022604
IEA
Genome Projectregulation of cell morphogenesis
GO:0030041
TAS, IEA
Genome Projectactin filament polymerization
GO:0030838
IEA
Genome Projectpositive regulation of actin filament polymerization
GO:0043552
IEA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase activity
GO:0043652
IEA
Genome Projectengulfment of apoptotic cell
GO:0045216
IEA
Genome Projectcell-cell junction organization
GO:0048532
IEA
Genome Projectanatomical structure arrangement
GO:0048813
IEA
Genome Projectdendrite morphogenesis
GO:0048873
IEA
Genome Projecthomeostasis of number of cells within a tissue
GO:0051932
IEA
Genome Projectsynaptic transmission, GABAergic
GO:0060071
IEA
Genome ProjectWnt signaling pathway, planar cell polarity pathway
GO:0071542
IEA
Genome Projectdopaminergic neuron differentiation
GO:0072659
IEA
Genome Projectprotein localization to plasma membrane
GO:0090103
IEA
Genome Projectcochlea morphogenesis
GO:0097178
IEA
Genome Projectruffle assembly
GO:0001934
IMP
Genome Projectpositive regulation of protein phosphorylation
GO:0006928
TAS
Genome Projectmovement of cell or subcellular component
GO:0006954
TAS
Genome Projectinflammatory response
GO:0007160
NAS
Genome Projectcell-matrix adhesion
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008361
IMP, IGI
Genome Projectregulation of cell size
GO:0009611
TAS
Genome Projectresponse to wounding
GO:0009653
TAS
Genome Projectanatomical structure morphogenesis
GO:0010310
TAS
Genome Projectregulation of hydrogen peroxide metabolic process
GO:0010592
IDA, IMP
Genome Projectpositive regulation of lamellipodium assembly
GO:0010811
IGI
Genome Projectpositive regulation of cell-substrate adhesion
GO:0016032
TAS
Genome Projectviral process
GO:0030032
IMP
Genome Projectlamellipodium assembly
GO:0030036
IGI
Genome Projectactin cytoskeleton organization
GO:0030168
TAS
Genome Projectplatelet activation
GO:0030334
IMP
Genome Projectregulation of cell migration
GO:0031295
TAS
Genome ProjectT cell costimulation
GO:0031529
IDA
TAS
Genome Projectruffle organization
GO:0032707
IDA
Genome Projectnegative regulation of interleukin-23 production
GO:0034446
IMP
Genome Projectsubstrate adhesion-dependent cell spreading
GO:0035025
TAS
Genome Projectpositive regulation of Rho protein signal transduction
GO:0035556
TAS
Genome Projectintracellular signal transduction
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038096
TAS
Genome ProjectFc-gamma receptor signaling pathway involved in phagocytosis
GO:0043065
TAS
Genome Projectpositive regulation of apoptotic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048013
TAS
Genome Projectephrin receptor signaling pathway
GO:0048261
TAS
Genome Projectnegative regulation of receptor-mediated endocytosis
GO:0048870
IDA
Genome Projectcell motility
GO:0050690
TAS
Genome Projectregulation of defense response to virus by virus
GO:0051056
TAS
Genome Projectregulation of small GTPase mediated signal transduction
GO:0051496
IDA
Genome Projectpositive regulation of stress fiber assembly
GO:0051668
IMP
Genome Projectlocalization within membrane
GO:0051894
IDA
Genome Projectpositive regulation of focal adhesion assembly
GO:0060263
IDA
Genome Projectregulation of respiratory burst
GO:0071526
ISS
Genome Projectsemaphorin-plexin signaling pathway
GO:0090023
IMP
Genome Projectpositive regulation of neutrophil chemotaxis
GO:0097190
TAS
Genome Projectapoptotic signaling pathway
GO:1900026
IDA
Genome Projectpositive regulation of substrate adhesion-dependent cell spreading

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0003924
TAS, IEA
Genome ProjectGTPase activity
GO:0005525
IDA, IMP
IEA
Genome ProjectGTP binding
GO:0030742
IEA
Genome ProjectGTP-dependent protein binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0031996
IPI
Genome Projectthioesterase binding
GO:0051022
ISS
Genome ProjectRho GDP-dissociation inhibitor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001891
IEA
Genome Projectphagocytic cup
GO:0005622
IEA
Genome Projectintracellular
GO:0005634
IEA
Genome Projectnucleus
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0016020
ISS
IEA
Genome Projectmembrane
GO:0016023
IEA
Genome Projectcytoplasmic membrane-bounded vesicle
GO:0019897
IEA
Genome Projectextrinsic component of plasma membrane
GO:0031901
IEA
Genome Projectearly endosome membrane
GO:0032587
IEA
Genome Projectruffle membrane
GO:0042995
IEA
Genome Projectcell projection
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005789
TAS
Genome Projectendoplasmic reticulum membrane
GO:0005802
IDA
Genome Projecttrans-Golgi network
GO:0005829
ISS
TAS
Genome Projectcytosol
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0030027
IDA
Genome Projectlamellipodium
GO:0036464
IDA
Genome Projectcytoplasmic ribonucleoprotein granule
GO:0042470
IEA
Genome Projectmelanosome
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0005884
IDA
Genome Projectactin filament

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001806Small GTPase superfamily
IPR003578Small GTPase superfamily, Rho type
IPR005225Small GTP-binding protein domain
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.