Gene: ENSG00000135914 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000135914
Transcript Identifier
ENST00000258400
Gene Type
Coding gene
Location
2 : 231108517-231123764 : negative

Family Information

Homologous gene family
HOM03P000241
(150 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P026892
(4 genes in 4 species)
specific family

Descriptions

gene_descr
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled

Identifiers

Type Value
pidENSP00000258400
HGNC5294
UniprotP41595

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001755
ISS
IEA
Genome Projectneural crest cell migration
GO:0001819
IDA
Genome Projectpositive regulation of cytokine production
GO:0001938
IMP
Genome Projectpositive regulation of endothelial cell proliferation
GO:0002031
IEA
Genome ProjectG-protein coupled receptor internalization
GO:0003007
ISS
IEA
Genome Projectheart morphogenesis
GO:0003300
ISS
IEA
Genome Projectcardiac muscle hypertrophy
GO:0006182
IDA
Genome ProjectcGMP biosynthetic process
GO:0006874
IDA
Genome Projectcellular calcium ion homeostasis
GO:0006939
IEA
Genome Projectsmooth muscle contraction
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007186
IMP
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007202
IDA
Genome Projectactivation of phospholipase C activity
GO:0007205
ISS
IEA
Genome Projectprotein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007210
IMP
Genome Projectserotonin receptor signaling pathway
GO:0007507
IEA
Genome Projectheart development
GO:0007610
IEA
Genome Projectbehavior
GO:0008284
IDA, IMP
Genome Projectpositive regulation of cell proliferation
GO:0010507
IMP
Genome Projectnegative regulation of autophagy
GO:0010513
IDA
Genome Projectpositive regulation of phosphatidylinositol biosynthetic process
GO:0014033
ISS
IEA
Genome Projectneural crest cell differentiation
GO:0014065
IDA
Genome Projectphosphatidylinositol 3-kinase signaling
GO:0014827
IMP
Genome Projectintestine smooth muscle contraction
GO:0016310
IMP
Genome Projectphosphorylation
GO:0019722
IMP
Genome Projectcalcium-mediated signaling
GO:0034220
IEA
Genome Projection transmembrane transport
GO:0035733
IEA
Genome Projecthepatic stellate cell activation
GO:0042310
IMP
IEA
Genome Projectvasoconstriction
GO:0042493
IDA
Genome Projectresponse to drug
GO:0043066
ISS
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043123
IEP
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406
IDA
Genome Projectpositive regulation of MAP kinase activity
GO:0043547
IEA
Genome Projectpositive regulation of GTPase activity
GO:0043647
IEA
Genome Projectinositol phosphate metabolic process
GO:0048598
ISS
IEA
Genome Projectembryonic morphogenesis
GO:0050715
ISS
IEA
Genome Projectpositive regulation of cytokine secretion
GO:0050795
IMP
IEA
Genome Projectregulation of behavior
GO:0051000
IDA
Genome Projectpositive regulation of nitric-oxide synthase activity
GO:0051209
IDA, IMP
Genome Projectrelease of sequestered calcium ion into cytosol
GO:0051781
ISS
IEA
Genome Projectpositive regulation of cell division
GO:0060548
IMP
Genome Projectnegative regulation of cell death
GO:0070371
IMP
Genome ProjectERK1 and ERK2 cascade
GO:0070374
IDA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0070528
IMP
Genome Projectprotein kinase C signaling
GO:0071418
IEA
Genome Projectcellular response to amine stimulus
GO:0071502
ISS
IEA
Genome Projectcellular response to temperature stimulus
GO:1904015
IEA
Genome Projectcellular response to serotonin

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001965
IMP
Genome ProjectG-protein alpha-subunit binding
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0004930
IEA
Genome ProjectG-protein coupled receptor activity
GO:0004993
IDA
IEA
Genome Projectserotonin receptor activity
GO:0005096
ISS
IEA
Genome ProjectGTPase activator activity
GO:0008144
IDA
Genome Projectdrug binding
GO:0051378
IDA
IEA
Genome Projectserotonin binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005887
IEA
Genome Projectintegral component of plasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030054
IEA
Genome Projectcell junction
GO:0030425
IEA
Genome Projectdendrite
GO:0043005
IEA
Genome Projectneuron projection
GO:0043025
IEA
Genome Projectneuronal cell body
GO:0045202
IEA
Genome Projectsynapse

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000276G protein-coupled receptor, rhodopsin-like
IPR0004825-Hydroxytryptamine 2B receptor
IPR0022315-hydroxytryptamine receptor family
IPR017452GPCR, rhodopsin-like, 7TM

No MapMan annotations defined for this gene.