Gene: ENSG00000135744 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000135744
Transcript Identifier
ENST00000366667
Gene Type
Coding gene
Location
1 : 230703141-230710850 : negative

Family Information

Homologous gene family
HOM03P032465
(2 genes in 2 species)
specific family

Descriptions

gene_descr
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Identifiers

Type Value
pidENSP00000355627
HGNC333
UniprotP01019
UniprotB0ZBE2

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001543
IEA
Genome Projectovarian follicle rupture
GO:0001568
IEA
Genome Projectblood vessel development
GO:0001658
IEA
Genome Projectbranching involved in ureteric bud morphogenesis
GO:0001991
IEA
Genome Projectregulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0001998
IEA
Genome Projectangiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001999
IEA
Genome Projectrenal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
GO:0002018
NAS, IEA
Genome Projectrenin-angiotensin regulation of aldosterone production
GO:0002019
NAS, IEA
Genome Projectregulation of renal output by angiotensin
GO:0002027
IEA
Genome Projectregulation of heart rate
GO:0002035
IEA
Genome Projectbrain renin-angiotensin system
GO:0003051
IEA
Genome Projectangiotensin-mediated drinking behavior
GO:0003081
IEA
Genome Projectregulation of systemic arterial blood pressure by renin-angiotensin
GO:0003331
IEA
Genome Projectpositive regulation of extracellular matrix constituent secretion
GO:0006883
IEA
Genome Projectcellular sodium ion homeostasis
GO:0007160
IEA
Genome Projectcell-matrix adhesion
GO:0007166
IEA
Genome Projectcell surface receptor signaling pathway
GO:0007186
IDA
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007202
IEA
Genome Projectactivation of phospholipase C activity
GO:0007250
IEA
Genome Projectactivation of NF-kappaB-inducing kinase activity
GO:0007565
IEA
Genome Projectfemale pregnancy
GO:0007568
IEA
Genome Projectaging
GO:0007588
IEA
Genome Projectexcretion
GO:0008065
IEA
Genome Projectestablishment of blood-nerve barrier
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0009409
IEA
Genome Projectresponse to cold
GO:0009651
IEA
Genome Projectresponse to salt stress
GO:0010468
IEA
Genome Projectregulation of gene expression
GO:0010613
ISS
IEA
Genome Projectpositive regulation of cardiac muscle hypertrophy
GO:0010628
IEA
Genome Projectpositive regulation of gene expression
GO:0014061
IEA
Genome Projectregulation of norepinephrine secretion
GO:0014824
IEA
Genome Projectartery smooth muscle contraction
GO:0014873
ISS
IEA
Genome Projectresponse to muscle activity involved in regulation of muscle adaptation
GO:0016525
IEA
Genome Projectnegative regulation of angiogenesis
GO:0030198
IEA
Genome Projectextracellular matrix organization
GO:0030308
IEA
Genome Projectnegative regulation of cell growth
GO:0030432
IEA
Genome Projectperistalsis
GO:0032930
IEA
Genome Projectpositive regulation of superoxide anion generation
GO:0033138
IEA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0034104
IEA
Genome Projectnegative regulation of tissue remodeling
GO:0035411
IEA
Genome Projectcatenin import into nucleus
GO:0035813
NAS, IEA
Genome Projectregulation of renal sodium excretion
GO:0035815
IEA
Genome Projectpositive regulation of renal sodium excretion
GO:0040018
IEA
Genome Projectpositive regulation of multicellular organism growth
GO:0042310
IEA
Genome Projectvasoconstriction
GO:0042311
IEA
Genome Projectvasodilation
GO:0042445
IEA
Genome Projecthormone metabolic process
GO:0042756
IEA
Genome Projectdrinking behavior
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043085
IEA
Genome Projectpositive regulation of catalytic activity
GO:0043410
IEA
Genome Projectpositive regulation of MAPK cascade
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0045429
IEA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045723
IEA
Genome Projectpositive regulation of fatty acid biosynthetic process
GO:0045777
IEA
Genome Projectpositive regulation of blood pressure
GO:0045909
IEA
Genome Projectpositive regulation of vasodilation
GO:0046622
IEA
Genome Projectpositive regulation of organ growth
GO:0048143
IEA
Genome Projectastrocyte activation
GO:0048144
IEA
Genome Projectfibroblast proliferation
GO:0048146
ISS
IEA
Genome Projectpositive regulation of fibroblast proliferation
GO:0048169
IEA
Genome Projectregulation of long-term neuronal synaptic plasticity
GO:0048659
IEA
Genome Projectsmooth muscle cell proliferation
GO:0050663
IEA
Genome Projectcytokine secretion
GO:0050727
IEA
Genome Projectregulation of inflammatory response
GO:0051145
IEA
Genome Projectsmooth muscle cell differentiation
GO:0051403
IEA
Genome Projectstress-activated MAPK cascade
GO:0051924
IEA
Genome Projectregulation of calcium ion transport
GO:0051969
IEA
Genome Projectregulation of transmission of nerve impulse
GO:0061049
IEA
Genome Projectcell growth involved in cardiac muscle cell development
GO:0070371
IEA
Genome ProjectERK1 and ERK2 cascade
GO:0070471
IEA
Genome Projectuterine smooth muscle contraction
GO:0071260
IEA
Genome Projectcellular response to mechanical stimulus
GO:1900020
IEA
Genome Projectpositive regulation of protein kinase C activity
GO:0001558
NAS
Genome Projectregulation of cell growth
GO:0001819
TAS
Genome Projectpositive regulation of cytokine production
GO:0001822
IMP
Genome Projectkidney development
GO:0001974
TAS
Genome Projectblood vessel remodeling
GO:0002003
TAS
Genome Projectangiotensin maturation
GO:0002016
NAS
Genome Projectregulation of blood volume by renin-angiotensin
GO:0002034
TAS
Genome Projectregulation of blood vessel size by renin-angiotensin
GO:0003014
IDA
Genome Projectrenal system process
GO:0007199
TAS
Genome ProjectG-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007200
NAS
Genome Projectphospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007263
TAS
Genome Projectnitric oxide mediated signal transduction
GO:0007267
TAS
Genome Projectcell-cell signaling
GO:0008217
IGI
Genome Projectregulation of blood pressure
GO:0010535
IMP
Genome Projectpositive regulation of activation of JAK2 kinase activity
GO:0010595
IDA
Genome Projectpositive regulation of endothelial cell migration
GO:0010744
IC
Genome Projectpositive regulation of macrophage derived foam cell differentiation
GO:0010873
IDA
Genome Projectpositive regulation of cholesterol esterification
GO:0010951
IBA
Genome Projectnegative regulation of endopeptidase activity
GO:0014068
IDA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0019229
NAS
Genome Projectregulation of vasoconstriction
GO:0032270
IDA
Genome Projectpositive regulation of cellular protein metabolic process
GO:0033864
TAS
Genome Projectpositive regulation of NAD(P)H oxidase activity
GO:0034374
NAS
Genome Projectlow-density lipoprotein particle remodeling
GO:0042127
NAS
Genome Projectregulation of cell proliferation
GO:0044255
TAS
Genome Projectcellular lipid metabolic process
GO:0044267
TAS
Genome Projectcellular protein metabolic process
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045742
IDA
Genome Projectpositive regulation of epidermal growth factor receptor signaling pathway
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0050729
TAS
Genome Projectpositive regulation of inflammatory response
GO:0050731
IDA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050880
IEA
Genome Projectregulation of blood vessel size
GO:0051092
TAS
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051387
IDA
Genome Projectnegative regulation of neurotrophin TRK receptor signaling pathway
GO:0061098
IMP
Genome Projectpositive regulation of protein tyrosine kinase activity
GO:0090190
IDA
Genome Projectpositive regulation of branching involved in ureteric bud morphogenesis
GO:1901201
IGI
Genome Projectregulation of extracellular matrix assembly
GO:1902632
IMP
Genome Projectpositive regulation of membrane hyperpolarization
GO:1903598
IGI
Genome Projectpositive regulation of gap junction assembly
GO:1903779
IGI
Genome Projectregulation of cardiac conduction
GO:2000379
TAS
Genome Projectpositive regulation of reactive oxygen species metabolic process
GO:2000650
TAS
Genome Projectnegative regulation of sodium ion transmembrane transporter activity
GO:2001238
IDA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005179
ISS
IC, IEA
Genome Projecthormone activity
GO:0031701
IEA
Genome Projectangiotensin receptor binding
GO:0031702
IPI
IEA
Genome Projecttype 1 angiotensin receptor binding
GO:0031703
IPI
IEA
Genome Projecttype 2 angiotensin receptor binding
GO:0004867
TAS
Genome Projectserine-type endopeptidase inhibitor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008083
TAS
Genome Projectgrowth factor activity
GO:0016176
TAS
Genome Projectsuperoxide-generating NADPH oxidase activator activity
GO:0017080
IMP
Genome Projectsodium channel regulator activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005615
IDA
ISS
IC, IEA
Genome Projectextracellular space
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005576
TAS, NAS, IEA
Genome Projectextracellular region
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0072562
IDA
Genome Projectblood microparticle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000215Serpin family
IPR000227Angiotensinogen
IPR023795Serpin, conserved site
IPR023796Serpin domain

No MapMan annotations defined for this gene.