Gene: ENSG00000135439 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000135439
Transcript Identifier
ENST00000547588
Gene Type
Coding gene
Location
12 : 57726552-57738246 : negative

Family Information

Homologous gene family
HOM03P000082
(324 genes in 39 species)
specific family

Descriptions

gene_descr
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Identifiers

Type Value
pidENSP00000449241
HGNC16921
UniprotF8VVT9

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0007264
IEA
Genome Projectsmall GTPase mediated signal transduction
GO:0014068
IEA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0032147
IEA
Genome Projectactivation of protein kinase activity
GO:0033601
IEA
Genome Projectpositive regulation of mammary gland epithelial cell proliferation
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0043547
IEA
Genome Projectpositive regulation of GTPase activity
GO:0045860
IEA
Genome Projectpositive regulation of protein kinase activity
GO:0045944
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046427
IEA
Genome Projectpositive regulation of JAK-STAT cascade
GO:0060749
IEA
Genome Projectmammary gland alveolus development
GO:2001240
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005096
IEA
Genome ProjectGTPase activator activity
GO:0005525
IEA
Genome ProjectGTP binding
GO:0019901
IEA
Genome Projectprotein kinase binding
GO:0030295
IEA
Genome Projectprotein kinase activator activity
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005730
IDA
Genome Projectnucleolus
GO:0005739
IDA
Genome Projectmitochondrion

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001164Arf GTPase activating protein
IPR001806Small GTPase superfamily
IPR001849Pleckstrin homology domain
IPR002110Ankyrin repeat
IPR011993PH domain-like
IPR020683Ankyrin repeat-containing domain
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.