Gene: ENSG00000135341 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000135341
Transcript Identifier
ENST00000369329
Gene Type
Coding gene
Location
6 : 90516501-90586883 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P039463
(3 genes in 3 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
mitogen-activated protein kinase kinase kinase 7

Identifiers

Type Value
pidENSP00000358335
HGNC6859
UniprotO43318

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
IEA
Genome ProjectMAPK cascade
GO:0000186
IDA
Genome Projectactivation of MAPKK activity
GO:0000187
IDA
TAS
Genome Projectactivation of MAPK activity
GO:0001525
IEA
Genome Projectangiogenesis
GO:0001841
IEA
Genome Projectneural tube formation
GO:0002223
TAS
Genome Projectstimulatory C-type lectin receptor signaling pathway
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002726
IMP
Genome Projectpositive regulation of T cell cytokine production
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0006915
IEA
Genome Projectapoptotic process
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007179
TAS, IEA
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007249
TAS
Genome ProjectI-kappaB kinase/NF-kappaB signaling
GO:0007250
IMP
Genome Projectactivation of NF-kappaB-inducing kinase activity
GO:0007252
IDA
IEA
Genome ProjectI-kappaB phosphorylation
GO:0007254
IDA
TAS
Genome ProjectJNK cascade
GO:0016310
IEA
Genome Projectphosphorylation
GO:0032743
IMP
Genome Projectpositive regulation of interleukin-2 production
GO:0034134
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0035872
TAS
Genome Projectnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0043123
IMP
IEA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043507
IDA, IMP
Genome Projectpositive regulation of JUN kinase activity
GO:0043966
IDA
Genome Projecthistone H3 acetylation
GO:0045087
TAS
Genome Projectinnate immune response
GO:0046330
IEA
Genome Projectpositive regulation of JNK cascade
GO:0050852
TAS, NAS
Genome ProjectT cell receptor signaling pathway
GO:0050870
IC
Genome Projectpositive regulation of T cell activation
GO:0051092
TAS
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051403
IDA
TAS
Genome Projectstress-activated MAPK cascade
GO:0070423
TAS
Genome Projectnucleotide-binding oligomerization domain containing signaling pathway
GO:1902443
IEA
Genome Projectnegative regulation of ripoptosome assembly involved in necroptotic process
GO:2000377
IEA
Genome Projectregulation of reactive oxygen species metabolic process
GO:2001234
IEA
Genome Projectnegative regulation of apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0000287
IEA
Genome Projectmagnesium ion binding
GO:0004672
IDA
IEA
Genome Projectprotein kinase activity
GO:0004674
EXP
TAS, IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004708
IEA
Genome ProjectMAP kinase kinase activity
GO:0004709
IDA
TAS, IEA
Genome ProjectMAP kinase kinase kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0097110
IDA
Genome Projectscaffold protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
Genome Projectnucleus
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005671
IDA
Genome ProjectAda2/Gcn5/Ada3 transcription activator complex
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
IEA
Genome Projectplasma membrane
GO:0010008
TAS
Genome Projectendosome membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0097481
IEA
Genome Projectneuronal postsynaptic density
GO:0008385
IPI
Genome ProjectIkappaB kinase complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017421Mitogen-activated protein (MAP) kinase kinase kinase 7
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.