Gene: ENSG00000134982 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000134982
Transcript Identifier
ENST00000508376
Gene Type
Coding gene
Location
5 : 112754891-112844126 : positive

Family Information

Homologous gene family
HOM03P013209
(6 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P029792
(3 genes in 2 species)
specific family

Descriptions

gene_descr
adenomatous polyposis coli

Identifiers

Type Value
pidENSP00000427089
HGNC583
UniprotP25054

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000281
IMP
IEA
Genome Projectmitotic cytokinesis
GO:0001822
IEA
Genome Projectkidney development
GO:0001942
IEA
Genome Projecthair follicle development
GO:0006461
IDA
Genome Projectprotein complex assembly
GO:0006915
TAS
Genome Projectapoptotic process
GO:0006921
TAS
Genome Projectcellular component disassembly involved in execution phase of apoptosis
GO:0006974
IDA
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0007026
IDA, IMP
IEA
Genome Projectnegative regulation of microtubule depolymerization
GO:0007050
IDA
IEA
Genome Projectcell cycle arrest
GO:0007091
IEA
Genome Projectmetaphase/anaphase transition of mitotic cell cycle
GO:0007094
IMP
Genome Projectmitotic spindle assembly checkpoint
GO:0007155
NAS
Genome Projectcell adhesion
GO:0007389
IEA
Genome Projectpattern specification process
GO:0007409
IEA
Genome Projectaxonogenesis
GO:0008285
IDA
IEA
Genome Projectnegative regulation of cell proliferation
GO:0009798
IEA
Genome Projectaxis specification
GO:0009952
IEA
Genome Projectanterior/posterior pattern specification
GO:0009953
IEA
Genome Projectdorsal/ventral pattern formation
GO:0009954
IEA
Genome Projectproximal/distal pattern formation
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0016055
IEA
Genome ProjectWnt signaling pathway
GO:0016477
IMP
IEA
Genome Projectcell migration
GO:0019827
IEA
Genome Projectstem cell population maintenance
GO:0030178
IEA
Genome Projectnegative regulation of Wnt signaling pathway
GO:0030334
IEA
Genome Projectregulation of cell migration
GO:0030335
IMP
Genome Projectpositive regulation of cell migration
GO:0030856
IEA
Genome Projectregulation of epithelial cell differentiation
GO:0030858
IEA
Genome Projectpositive regulation of epithelial cell differentiation
GO:0031116
IEA
Genome Projectpositive regulation of microtubule polymerization
GO:0031122
IEA
Genome Projectcytoplasmic microtubule organization
GO:0031274
IMP
Genome Projectpositive regulation of pseudopodium assembly
GO:0032886
IMP
Genome Projectregulation of microtubule-based process
GO:0033077
IEA
Genome ProjectT cell differentiation in thymus
GO:0035019
IEA
Genome Projectsomatic stem cell population maintenance
GO:0042483
IEA
Genome Projectnegative regulation of odontogenesis
GO:0043065
IMP
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043409
IEA
Genome Projectnegative regulation of MAPK cascade
GO:0043588
IEA
Genome Projectskin development
GO:0044336
IEA
Genome Projectcanonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0044337
IEA
Genome Projectcanonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0045595
IEA
Genome Projectregulation of cell differentiation
GO:0045597
IEA
Genome Projectpositive regulation of cell differentiation
GO:0045667
IEA
Genome Projectregulation of osteoblast differentiation
GO:0045670
IEA
Genome Projectregulation of osteoclast differentiation
GO:0045732
IGI
IC
Genome Projectpositive regulation of protein catabolic process
GO:0045736
IDA
Genome Projectnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045785
IEA
Genome Projectpositive regulation of cell adhesion
GO:0046716
IEA
Genome Projectmuscle cell cellular homeostasis
GO:0048538
IEA
Genome Projectthymus development
GO:0050680
IEA
Genome Projectnegative regulation of epithelial cell proliferation
GO:0051171
IEA
Genome Projectregulation of nitrogen compound metabolic process
GO:0051276
IEA
Genome Projectchromosome organization
GO:0051726
IEA
Genome Projectregulation of cell cycle
GO:0051781
IEA
Genome Projectpositive regulation of cell division
GO:0051988
IMP
NAS
Genome Projectregulation of attachment of spindle microtubules to kinetochore
GO:0060041
IEA
Genome Projectretina development in camera-type eye
GO:0060070
NAS, IC, IEA
Genome Projectcanonical Wnt signaling pathway
GO:0060770
IEA
Genome Projectnegative regulation of epithelial cell proliferation involved in prostate gland development
GO:0070830
NAS
Genome Projectbicellular tight junction assembly
GO:0090090
IGI
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090263
TAS
Genome Projectpositive regulation of canonical Wnt signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0008013
IPI
IEA
Genome Projectbeta-catenin binding
GO:0008017
IDA
IEA
Genome Projectmicrotubule binding
GO:0019887
IDA
Genome Projectprotein kinase regulator activity
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0045295
IPI
Genome Projectgamma-catenin binding
GO:0051010
IDA
Genome Projectmicrotubule plus-end binding
GO:0045296
IDA
Genome Projectcadherin binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000776
IDA
Genome Projectkinetochore
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005813
IDA
Genome Projectcentrosome
GO:0005829
TAS
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005874
IEA
Genome Projectmicrotubule
GO:0005881
IEA
Genome Projectcytoplasmic microtubule
GO:0005886
IDA
IEA
Genome Projectplasma membrane
GO:0005912
IEA
Genome Projectadherens junction
GO:0005923
IDA
Genome Projectbicellular tight junction
GO:0016020
IEA
Genome Projectmembrane
GO:0016328
IDA
Genome Projectlateral plasma membrane
GO:0016342
IDA
Genome Projectcatenin complex
GO:0030027
IDA
IEA
Genome Projectlamellipodium
GO:0030054
IEA
Genome Projectcell junction
GO:0030424
IEA
Genome Projectaxon
GO:0030426
IEA
Genome Projectgrowth cone
GO:0030877
IDA
Genome Projectbeta-catenin destruction complex
GO:0031253
IEA
Genome Projectcell projection membrane
GO:0032587
IDA
IEA
Genome Projectruffle membrane
GO:0035371
IEA
Genome Projectmicrotubule plus-end
GO:0042995
IEA
Genome Projectcell projection
GO:0044295
IEA
Genome Projectaxonal growth cone
GO:0005913
IDA
Genome Projectcell-cell adherens junction

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000225Armadillo
IPR009223Adenomatous polyposis coli protein, cysteine-rich repeat
IPR009224SAMP
IPR009232EB-1 binding
IPR009234Adenomatous polyposis coli protein basic domain
IPR009240Adenomatous polyposis coli protein, 15 residue repeat
IPR011989Armadillo-like helical
IPR016024Armadillo-type fold
IPR026818Adenomatous polyposis coli (APC) family
IPR026831Adenomatous polyposis coli protein
IPR026836Adenomatous polyposis coli
IPR032038Adenomatous polyposis coli, N-terminal dimerisation domain

No MapMan annotations defined for this gene.