Gene: ENSG00000134352 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000134352
Transcript Identifier
ENST00000502326
Gene Type
Coding gene
Location
5 : 55941082-55976278 : negative

Family Information

Homologous gene family
HOM03P010213
(8 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P076275
(2 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
interleukin 6 signal transducer

Identifiers

Type Value
pidENSP00000462158
HGNC6021
UniprotP40189

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002675
IC
Genome Projectpositive regulation of acute inflammatory response
GO:0002821
IC
Genome Projectpositive regulation of adaptive immune response
GO:0005977
IEA
Genome Projectglycogen metabolic process
GO:0007165
IEA
Genome Projectsignal transduction
GO:0008284
IDA, IGI
Genome Projectpositive regulation of cell proliferation
GO:0008593
IEA
Genome Projectregulation of Notch signaling pathway
GO:0010575
TAS
Genome Projectpositive regulation of vascular endothelial growth factor production
GO:0010613
TAS
Genome Projectpositive regulation of cardiac muscle hypertrophy
GO:0016032
IEA
Genome Projectviral process
GO:0019221
IDA
Genome Projectcytokine-mediated signaling pathway
GO:0034097
IDA
Genome Projectresponse to cytokine
GO:0038154
IEA
Genome Projectinterleukin-11-mediated signaling pathway
GO:0038165
IMP
Genome Projectoncostatin-M-mediated signaling pathway
GO:0042102
IMP
Genome Projectpositive regulation of T cell proliferation
GO:0042511
IMP
Genome Projectpositive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517
IMP
Genome Projectpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043066
TAS
Genome Projectnegative regulation of apoptotic process
GO:0045669
IMP
Genome Projectpositive regulation of osteoblast differentiation
GO:0048711
IEA
Genome Projectpositive regulation of astrocyte differentiation
GO:0048861
IDA
Genome Projectleukemia inhibitory factor signaling pathway
GO:0070102
IMP
Genome Projectinterleukin-6-mediated signaling pathway
GO:0070104
IDA
Genome Projectnegative regulation of interleukin-6-mediated signaling pathway
GO:0070106
IMP
Genome Projectinterleukin-27-mediated signaling pathway
GO:0070120
IDA
Genome Projectciliary neurotrophic factor-mediated signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004896
IEA
Genome Projectcytokine receptor activity
GO:0004897
IDA
Genome Projectciliary neurotrophic factor receptor activity
GO:0004921
IEA
Genome Projectinterleukin-11 receptor activity
GO:0005127
IPI
Genome Projectciliary neurotrophic factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0019838
IPI
Genome Projectgrowth factor binding
GO:0019970
IEA
Genome Projectinterleukin-11 binding
GO:0042803
TAS
Genome Projectprotein homodimerization activity
GO:0045509
IC
Genome Projectinterleukin-27 receptor activity
GO:0004915
IDA
Genome Projectinterleukin-6 receptor activity
GO:0004923
IDA
Genome Projectleukemia inhibitory factor receptor activity
GO:0004924
IDA
Genome Projectoncostatin-M receptor activity
GO:0005138
IPI
Genome Projectinterleukin-6 receptor binding
GO:0019981
IPI
Genome Projectinterleukin-6 binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005615
IDA
Genome Projectextracellular space
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0005896
IDA
Genome Projectinterleukin-6 receptor complex
GO:0005900
IDA
Genome Projectoncostatin-M receptor complex
GO:0009897
IEA
Genome Projectexternal side of plasma membrane
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030425
IEA
Genome Projectdendrite
GO:0043025
IEA
Genome Projectneuronal cell body
GO:0044297
IEA
Genome Projectcell body
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070110
IDA
Genome Projectciliary neurotrophic factor receptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003529Long hematopoietin receptor, Gp130 family 2, conserved site
IPR003961Fibronectin type III
IPR010457Immunoglobulin C2-set-like, ligand-binding
IPR013783Immunoglobulin-like fold
IPR015321Type I cytokine receptor, cytokine-binding domain

No MapMan annotations defined for this gene.