Gene: ENSG00000134318 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000134318
Transcript Identifier
ENST00000315872
Gene Type
Coding gene
Location
2 : 11183437-11344136 : negative

Family Information

Homologous gene family
HOM03P000015
(1237 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P014673
(6 genes in 4 species)
specific family

Descriptions

gene_descr
Rho-associated, coiled-coil containing protein kinase 2

Identifiers

Type Value
pidENSP00000317985
HGNC10252
UniprotO75116

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000910
NAS
Genome Projectcytokinesis
GO:0001843
IEA
Genome Projectneural tube closure
GO:0001934
IMP
Genome Projectpositive regulation of protein phosphorylation
GO:0006468
IDA
TAS, IEA
Genome Projectprotein phosphorylation
GO:0006939
TAS, IEA
Genome Projectsmooth muscle contraction
GO:0007264
TAS
Genome Projectsmall GTPase mediated signal transduction
GO:0007266
IEA
Genome ProjectRho protein signal transduction
GO:0007411
TAS
Genome Projectaxon guidance
GO:0008625
IEA
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0010595
IMP
Genome Projectpositive regulation of endothelial cell migration
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0010825
IEA
Genome Projectpositive regulation of centrosome duplication
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016525
IMP
Genome Projectnegative regulation of angiogenesis
GO:0030036
IEA
Genome Projectactin cytoskeleton organization
GO:0030155
TAS
Genome Projectregulation of cell adhesion
GO:0032956
TAS, IEA
Genome Projectregulation of actin cytoskeleton organization
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0042752
ISS
Genome Projectregulation of circadian rhythm
GO:0045616
IMP
Genome Projectregulation of keratinocyte differentiation
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048013
TAS
Genome Projectephrin receptor signaling pathway
GO:0048511
IEA
Genome Projectrhythmic process
GO:0048813
IEA
Genome Projectdendrite morphogenesis
GO:0051298
IMP
Genome Projectcentrosome duplication
GO:0051492
TAS
Genome Projectregulation of stress fiber assembly
GO:0051893
TAS
Genome Projectregulation of focal adhesion assembly
GO:0071394
IMP
Genome Projectcellular response to testosterone stimulus
GO:2000114
TAS
Genome Projectregulation of establishment of cell polarity
GO:2000145
TAS
Genome Projectregulation of cell motility

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
IDA
TAS, IEA
Genome Projectprotein serine/threonine kinase activity
GO:0005198
NAS
Genome Projectstructural molecule activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0017048
IEA
Genome ProjectRho GTPase binding
GO:0044822
IDA
Genome Projectpoly(A) RNA binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0072518
IMP
Genome ProjectRho-dependent protein serine/threonine kinase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
Genome Projectnucleus
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005813
IDA
Genome Projectcentrosome
GO:0005815
IEA
Genome Projectmicrotubule organizing center
GO:0005829
TAS
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005886
IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0031616
IEA
Genome Projectspindle pole centrosome
GO:0036464
IDA
Genome Projectcytoplasmic ribonucleoprotein granule

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR000961AGC-kinase, C-terminal
IPR001849Pleckstrin homology domain
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR011993PH domain-like
IPR015008Rho binding domain
IPR017441Protein kinase, ATP binding site
IPR020684Rho-associated protein kinase 1/2
IPR029878Rho-associated protein kinase 2

No MapMan annotations defined for this gene.