Gene: ENSG00000134259 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000134259
Transcript Identifier
ENST00000369512
Gene Type
Coding gene
Location
1 : 115286070-115286795 : negative

Family Information

Homologous gene family
HOM03P010566
(8 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P067019
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
nerve growth factor (beta polypeptide)

Identifiers

Type Value
pidENSP00000358525
HGNC7808
UniprotP01138

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000186
TAS
Genome Projectactivation of MAPKK activity
GO:0007169
IBA
TAS
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007202
TAS
Genome Projectactivation of phospholipase C activity
GO:0007264
TAS
Genome Projectsmall GTPase mediated signal transduction
GO:0007265
TAS
Genome ProjectRas protein signal transduction
GO:0007267
IBA
Genome Projectcell-cell signaling
GO:0007422
IEA
Genome Projectperipheral nervous system development
GO:0008625
IDA
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0010466
IEA
Genome Projectnegative regulation of peptidase activity
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0010951
IDA
IEA
Genome Projectnegative regulation of endopeptidase activity
GO:0010976
IEA
Genome Projectpositive regulation of neuron projection development
GO:0014042
IEA
Genome Projectpositive regulation of neuron maturation
GO:0019233
IEA
Genome Projectsensory perception of pain
GO:0032455
TAS
Genome Projectnerve growth factor processing
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0038180
IEA
Genome Projectnerve growth factor signaling pathway
GO:0043065
TAS
Genome Projectpositive regulation of apoptotic process
GO:0043066
TAS
Genome Projectnegative regulation of apoptotic process
GO:0043281
TAS
Genome Projectregulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524
IBA
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0045664
IBA
IEA
Genome Projectregulation of neuron differentiation
GO:0045773
IEA
Genome Projectpositive regulation of axon extension
GO:0045786
TAS
Genome Projectnegative regulation of cell cycle
GO:0046928
IEA
Genome Projectregulation of neurotransmitter secretion
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048015
TAS
Genome Projectphosphatidylinositol-mediated signaling
GO:0048672
IEA
Genome Projectpositive regulation of collateral sprouting
GO:0048812
IDA
Genome Projectneuron projection morphogenesis
GO:0050770
TAS
Genome Projectregulation of axonogenesis
GO:0050772
TAS
Genome Projectpositive regulation of axonogenesis
GO:0051279
IEA
Genome Projectregulation of release of sequestered calcium ion into cytosol
GO:0051402
IEA
Genome Projectneuron apoptotic process
GO:0097190
TAS
Genome Projectapoptotic signaling pathway
GO:0097192
IEA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004857
IEA
Genome Projectenzyme inhibitor activity
GO:0005057
IEA
Genome Projectreceptor signaling protein activity
GO:0005102
IEA
Genome Projectreceptor binding
GO:0005163
IPI
Genome Projectnerve growth factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008083
IBA
IEA
Genome Projectgrowth factor activity
GO:0008191
IDA
IEA
Genome Projectmetalloendopeptidase inhibitor activity
GO:0030414
IEA
Genome Projectpeptidase inhibitor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005768
TAS
Genome Projectendosome
GO:0005796
TAS
Genome ProjectGolgi lumen
GO:0016023
IBA
Genome Projectcytoplasmic membrane-bounded vesicle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002072Nerve growth factor-related
IPR019846Nerve growth factor conserved site
IPR020408Nerve growth factor-like
IPR020425Nerve growth factor, beta subunit
IPR020437Nerve growth factor, beta subunit, mammalian
IPR029034Cystine-knot cytokine

No MapMan annotations defined for this gene.