Gene: ENSG00000134070 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000134070
Transcript Identifier
ENST00000256458
Gene Type
Coding gene
Location
3 : 10164955-10242228 : positive

Family Information

Homologous gene family
HOM03P000002
(4173 genes in 39 species)
specific family

Descriptions

gene_descr
interleukin-1 receptor-associated kinase 2

Identifiers

Type Value
pidENSP00000256458
HGNC6113
UniprotO43187

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
TAS
Genome Projectactivation of MAPK activity
GO:0001959
IMP
Genome Projectregulation of cytokine-mediated signaling pathway
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0006468
TAS, IEA
Genome Projectprotein phosphorylation
GO:0006954
TAS
Genome Projectinflammatory response
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007249
TAS
Genome ProjectI-kappaB kinase/NF-kappaB signaling
GO:0007254
TAS
Genome ProjectJNK cascade
GO:0031663
IEA
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0032088
IMP
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0034134
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0035872
TAS
Genome Projectnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0043433
IEA
Genome Projectnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087
TAS
Genome Projectinnate immune response
GO:0051092
IMP
TAS
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051403
TAS
Genome Projectstress-activated MAPK cascade
GO:0070423
TAS
Genome Projectnucleotide-binding oligomerization domain containing signaling pathway
GO:0070498
IMP
Genome Projectinterleukin-1-mediated signaling pathway
GO:0070555
IMP
Genome Projectresponse to interleukin-1

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
IBA
Genome Projectprotein serine/threonine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0042803
IPI
Genome Projectprotein homodimerization activity
GO:0046982
IPI
Genome Projectprotein heterodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IBA
Genome Projectnucleus
GO:0005737
IBA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
IBA
TAS
Genome Projectplasma membrane
GO:0010008
TAS
Genome Projectendosome membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000488Death domain
IPR000719Protein kinase domain
IPR011009Protein kinase-like domain
IPR011029Death-like domain

No MapMan annotations defined for this gene.