Gene: ENSG00000132170 (Homo sapiens)

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Gene Identifier
ENSG00000132170
Transcript Identifier
ENST00000287820
Gene Type
Coding gene
Location
3 : 12351593-12434145 : positive

Family Information

Homologous gene family
HOM03P000128
(228 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P017214
(5 genes in 3 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
peroxisome proliferator-activated receptor gamma

Identifiers

Type Value
pidENSP00000287820
HGNC9236
UniprotP37231

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IDA
ISS
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001890
ISS
IEA
Genome Projectplacenta development
GO:0002021
IEA
Genome Projectresponse to dietary excess
GO:0002024
IEA
Genome Projectdiet induced thermogenesis
GO:0002674
IEA
Genome Projectnegative regulation of acute inflammatory response
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006357
IEA
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0006367
TAS
Genome Projecttranscription initiation from RNA polymerase II promoter
GO:0006629
TAS
Genome Projectlipid metabolic process
GO:0006919
IDA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165
IDA
Genome Projectsignal transduction
GO:0007186
TAS
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007507
IEA
Genome Projectheart development
GO:0007584
TAS
Genome Projectresponse to nutrient
GO:0008217
IMP
Genome Projectregulation of blood pressure
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0009409
IEA
Genome Projectresponse to cold
GO:0009612
IEA
Genome Projectresponse to mechanical stimulus
GO:0010033
IEA
Genome Projectresponse to organic substance
GO:0010467
TAS
Genome Projectgene expression
GO:0010468
IEA
Genome Projectregulation of gene expression
GO:0010745
IDA
IC
Genome Projectnegative regulation of macrophage derived foam cell differentiation
GO:0010871
IDA
Genome Projectnegative regulation of receptor biosynthetic process
GO:0010887
IDA
Genome Projectnegative regulation of cholesterol storage
GO:0010891
IDA
Genome Projectnegative regulation of sequestering of triglyceride
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0015909
ISS
IEA
Genome Projectlong-chain fatty acid transport
GO:0019216
IEA
Genome Projectregulation of lipid metabolic process
GO:0019395
IEA
Genome Projectfatty acid oxidation
GO:0030224
IDA
Genome Projectmonocyte differentiation
GO:0030308
IEA
Genome Projectnegative regulation of cell growth
GO:0030855
ISS
IEA
Genome Projectepithelial cell differentiation
GO:0031000
IEA
Genome Projectresponse to caffeine
GO:0031100
IEA
Genome Projectorgan regeneration
GO:0032526
IDA
Genome Projectresponse to retinoic acid
GO:0032869
IMP
Genome Projectcellular response to insulin stimulus
GO:0032966
IEA
Genome Projectnegative regulation of collagen biosynthetic process
GO:0033189
IEA
Genome Projectresponse to vitamin A
GO:0033993
ISS
IEA
Genome Projectresponse to lipid
GO:0035357
IMP
Genome Projectperoxisome proliferator activated receptor signaling pathway
GO:0035902
IEA
Genome Projectresponse to immobilization stress
GO:0036270
IEA
Genome Projectresponse to diuretic
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042593
IMP
Genome Projectglucose homeostasis
GO:0042594
IEA
Genome Projectresponse to starvation
GO:0042752
ISS
Genome Projectregulation of circadian rhythm
GO:0042953
IDA
Genome Projectlipoprotein transport
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043401
IEA
Genome Projectsteroid hormone mediated signaling pathway
GO:0043627
IEA
Genome Projectresponse to estrogen
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045165
ISS
IEA
Genome Projectcell fate commitment
GO:0045444
IEA
Genome Projectfat cell differentiation
GO:0045598
IEA
Genome Projectregulation of fat cell differentiation
GO:0045600
ISS
IEA
Genome Projectpositive regulation of fat cell differentiation
GO:0045713
IDA
Genome Projectlow-density lipoprotein particle receptor biosynthetic process
GO:0045892
ISS
IEA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
ISS
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IMP
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046321
IEA
Genome Projectpositive regulation of fatty acid oxidation
GO:0048469
IDA
Genome Projectcell maturation
GO:0048511
IEA
Genome Projectrhythmic process
GO:0048662
IDA
Genome Projectnegative regulation of smooth muscle cell proliferation
GO:0048714
IEA
Genome Projectpositive regulation of oligodendrocyte differentiation
GO:0050872
ISS
TAS, IEA
Genome Projectwhite fat cell differentiation
GO:0050873
IEA
Genome Projectbrown fat cell differentiation
GO:0051091
IDA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051974
IEA
Genome Projectnegative regulation of telomerase activity
GO:0055088
TAS
Genome Projectlipid homeostasis
GO:0055098
IDA
Genome Projectresponse to low-density lipoprotein particle
GO:0060100
IEA
Genome Projectpositive regulation of phagocytosis, engulfment
GO:0060336
IMP
Genome Projectnegative regulation of interferon-gamma-mediated signaling pathway
GO:0060694
IC
Genome Projectregulation of cholesterol transporter activity
GO:0060850
ISS
Genome Projectregulation of transcription involved in cell fate commitment
GO:0071285
IEA
Genome Projectcellular response to lithium ion
GO:0071300
IEA
Genome Projectcellular response to retinoic acid
GO:0071306
IEA
Genome Projectcellular response to vitamin E
GO:0071379
IEA
Genome Projectcellular response to prostaglandin stimulus
GO:0071380
IEA
Genome Projectcellular response to prostaglandin E stimulus
GO:0071407
IEA
Genome Projectcellular response to organic cyclic compound
GO:0071455
IEA
Genome Projectcellular response to hyperoxia
GO:1901558
IEA
Genome Projectresponse to metformin
GO:2000230
IEA
Genome Projectnegative regulation of pancreatic stellate cell proliferation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001012
IEA
Genome ProjectRNA polymerase II regulatory region DNA binding
GO:0001046
ISS
Genome Projectcore promoter sequence-specific DNA binding
GO:0001228
IEA
Genome Projecttranscriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677
IDA
ISS
IEA
Genome ProjectDNA binding
GO:0003682
ISS
IEA
Genome Projectchromatin binding
GO:0003700
IDA
ISS
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0003707
IEA
Genome Projectsteroid hormone receptor activity
GO:0004879
IDA
IEA
Genome ProjectRNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0004955
TAS
Genome Projectprostaglandin receptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IEA
Genome Projecttranscription factor binding
GO:0008144
IDA
Genome Projectdrug binding
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019903
IEA
Genome Projectprotein phosphatase binding
GO:0030331
IEA
Genome Projectestrogen receptor binding
GO:0030374
IDA
Genome Projectligand-dependent nuclear receptor transcription coactivator activity
GO:0033613
IDA
Genome Projectactivating transcription factor binding
GO:0043565
IDA
IEA
Genome Projectsequence-specific DNA binding
GO:0044212
IDA
ISS
IEA
Genome Projecttranscription regulatory region DNA binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0046965
IDA
Genome Projectretinoid X receptor binding
GO:0050544
ISS
Genome Projectarachidonic acid binding
GO:0051393
IPI
Genome Projectalpha-actinin binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005829
ISS
IEA
Genome Projectcytosol
GO:0048471
IEA
Genome Projectperinuclear region of cytoplasm
GO:0090575
IDA
Genome ProjectRNA polymerase II transcription factor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000536Nuclear hormone receptor, ligand-binding domain
IPR001628Zinc finger, nuclear hormone receptor-type
IPR001723Nuclear hormone receptor
IPR003074Peroxisome proliferator-activated receptor
IPR003077Peroxisome proliferator-activated receptor, gamma
IPR013088Zinc finger, NHR/GATA-type
IPR022590Peroxisome proliferator-activated receptor gamma, N-terminal

No MapMan annotations defined for this gene.