Gene: ENSG00000132155 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000132155
Transcript Identifier
ENST00000442415
Gene Type
Coding gene
Location
3 : 12584514-12618721 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P012430
(7 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
Raf-1 proto-oncogene, serine/threonine kinase

Identifiers

Type Value
pidENSP00000401888
HGNC9829
UniprotP04049

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
TAS, IEA
Genome ProjectMAPK cascade
GO:0000186
IDA
TAS
Genome Projectactivation of MAPKK activity
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0001678
IEA
Genome Projectcellular glucose homeostasis
GO:0001934
IEA
Genome Projectpositive regulation of protein phosphorylation
GO:0002223
TAS
Genome Projectstimulatory C-type lectin receptor signaling pathway
GO:0006468
TAS, IEA
Genome Projectprotein phosphorylation
GO:0006915
TAS
Genome Projectapoptotic process
GO:0007165
TAS, IEA
Genome Projectsignal transduction
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007190
NAS
Genome Projectactivation of adenylate cyclase activity
GO:0007264
TAS
Genome Projectsmall GTPase mediated signal transduction
GO:0007265
TAS
Genome ProjectRas protein signal transduction
GO:0007268
TAS
Genome Projectsynaptic transmission
GO:0007411
TAS
Genome Projectaxon guidance
GO:0007507
IEA
Genome Projectheart development
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008283
TAS
Genome Projectcell proliferation
GO:0008285
IDA
Genome Projectnegative regulation of cell proliferation
GO:0008286
TAS
Genome Projectinsulin receptor signaling pathway
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0016310
IEA
Genome Projectphosphorylation
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030168
TAS
Genome Projectplatelet activation
GO:0031333
IDA
Genome Projectnegative regulation of protein complex assembly
GO:0033138
IDA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0034220
TAS
Genome Projection transmembrane transport
GO:0035019
IEA
Genome Projectsomatic stem cell population maintenance
GO:0035023
TAS
Genome Projectregulation of Rho protein signal transduction
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0035773
IEA
Genome Projectinsulin secretion involved in cellular response to glucose stimulus
GO:0035994
IEA
Genome Projectresponse to muscle stretch
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0042060
TAS
Genome Projectwound healing
GO:0042981
TAS
Genome Projectregulation of apoptotic process
GO:0043066
IDA
Genome Projectnegative regulation of apoptotic process
GO:0043154
TAS
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045104
IEA
Genome Projectintermediate filament cytoskeleton organization
GO:0045595
TAS
Genome Projectregulation of cell differentiation
GO:0045944
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048011
TAS, IEA
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0055085
TAS
Genome Projecttransmembrane transport
GO:0071550
IEA
Genome Projectdeath-inducing signaling complex assembly
GO:1902042
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000145
TAS
Genome Projectregulation of cell motility

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
TAS, IEA
Genome Projectprotein kinase activity
GO:0004674
IDA
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004709
IEA
Genome ProjectMAP kinase kinase kinase activity
GO:0005057
IEA
Genome Projectreceptor signaling protein activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0031434
IEA
Genome Projectmitogen-activated protein kinase kinase binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0046982
IEA
Genome Projectprotein heterodimerization activity
GO:0031267
IPI
Genome Projectsmall GTPase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
Genome Projectnucleus
GO:0005737
IDA
ISS
IEA
Genome Projectcytoplasm
GO:0005739
IEA
Genome Projectmitochondrion
GO:0005741
TAS
Genome Projectmitochondrial outer membrane
GO:0005794
IPI
Genome ProjectGolgi apparatus
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0031143
IEA
Genome Projectpseudopodium

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR003116Raf-like Ras-binding
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site
IPR020454Diacylglycerol/phorbol-ester binding
IPR029071Ubiquitin-related domain

No MapMan annotations defined for this gene.