Gene: ENSG00000131747 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000131747
Transcript Identifier
ENST00000423485
Gene Type
Coding gene
Location
17 : 40389519-40417791 : negative

Family Information

Homologous gene family
HOM03P000971
(63 genes in 39 species)
specific family

Descriptions

gene_descr
topoisomerase (DNA) II alpha 170kDa

Identifiers

Type Value
pidENSP00000411532
HGNC11989
UniprotP11388

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000278
TAS
Genome Projectmitotic cell cycle
GO:0000712
IBA
Genome Projectresolution of meiotic recombination intermediates
GO:0000819
IBA
Genome Projectsister chromatid segregation
GO:0002244
IEA
Genome Projecthematopoietic progenitor cell differentiation
GO:0006259
IEA
Genome ProjectDNA metabolic process
GO:0006265
IDA
IEA
Genome ProjectDNA topological change
GO:0006266
IDA
Genome ProjectDNA ligation
GO:0006268
IBA
Genome ProjectDNA unwinding involved in DNA replication
GO:0006974
IDA
Genome Projectcellular response to DNA damage stimulus
GO:0007059
IMP
Genome Projectchromosome segregation
GO:0030261
IEA
Genome Projectchromosome condensation
GO:0030263
IDA
Genome Projectapoptotic chromosome condensation
GO:0040016
IEA
Genome Projectembryonic cleavage
GO:0042752
ISS
IEA
Genome Projectregulation of circadian rhythm
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0044774
IBA
Genome Projectmitotic DNA integrity checkpoint
GO:0045070
IMP
Genome Projectpositive regulation of viral genome replication
GO:0045870
IMP
Genome Projectpositive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045944
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048511
IEA
Genome Projectrhythmic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0000287
IDA
IEA
Genome Projectmagnesium ion binding
GO:0003677
IDA
IEA
Genome ProjectDNA binding
GO:0003682
IDA
Genome Projectchromatin binding
GO:0003916
IEA
Genome ProjectDNA topoisomerase activity
GO:0003918
IDA
IEA
Genome ProjectDNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080
IPI
Genome Projectprotein kinase C binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008022
IPI
Genome Projectprotein C-terminus binding
GO:0008094
IDA
Genome ProjectDNA-dependent ATPase activity
GO:0008144
IDA
Genome Projectdrug binding
GO:0008301
IDA
IEA
Genome ProjectDNA binding, bending
GO:0016853
IEA
Genome Projectisomerase activity
GO:0019899
IPI
Genome Projectenzyme binding
GO:0042803
IPI
Genome Projectprotein homodimerization activity
GO:0042826
IPI
Genome Projecthistone deacetylase binding
GO:0043130
IMP
Genome Projectubiquitin binding
GO:0044822
IDA
Genome Projectpoly(A) RNA binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0046982
IPI
Genome Projectprotein heterodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000793
IEA
Genome Projectcondensed chromosome
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
IDA
TAS, IEA
Genome Projectnucleoplasm
GO:0005730
IDA
Genome Projectnucleolus
GO:0005737
IEA
Genome Projectcytoplasm
GO:0009330
IDA
Genome ProjectDNA topoisomerase complex (ATP-hydrolyzing)
GO:0043234
IDA
Genome Projectprotein complex
GO:0009295
IBA
Genome Projectnucleoid
GO:0000228
IDA
Genome Projectnuclear chromosome
GO:0005814
IDA
Genome Projectcentriole
GO:0019035
NAS
Genome Projectviral integration complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001154DNA topoisomerase II, eukaryotic-type
IPR001241DNA topoisomerase, type IIA
IPR002205DNA topoisomerase, type IIA, subunit A/C-terminal
IPR003594Histidine kinase-like ATPase, C-terminal domain
IPR006171Toprim domain
IPR012542DTHCT
IPR013506DNA topoisomerase, type IIA, subunit B, domain 2
IPR013757Type IIA DNA topoisomerase subunit A, alpha-helical domain
IPR013758DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
IPR013759DNA topoisomerase, type IIA, central domain
IPR013760DNA topoisomerase, type IIA-like domain
IPR014721Ribosomal protein S5 domain 2-type fold, subgroup
IPR018522DNA topoisomerase, type IIA, conserved site
IPR020568Ribosomal protein S5 domain 2-type fold
IPR024946Arginine repressor C-terminal-like domain
IPR028466DNA topoisomerase II-alpha
IPR031660C-terminal associated domain of TOPRIM

No MapMan annotations defined for this gene.